Posted by admin on Jan 31, 2021 in |
Growth and development events in plants are controlled by growth regulators and Phytohormones. These are found naturally in plants. Environmental Pollution is one of the major problems and reactions caused by artificial growth regulators and their low biodegradability has urged us to search for new biofertilizers with growth-regulating activity. Vermiwash is a liquid fertilizer that has been shown to mimic phytohormones in bringing about growth-promoting effects. In the present study vermiwash at 100% and 50% concentration and Gibberellic acid treatment along with a control treatment with distilled water were given to Hibiscus cannabinus L.,a conventional fiber crop in order to determine the growth-promoting effect of vermiwash in comparison to Gibberellic acid. The results showed that vermiwash at lower concentration was able to bring about enhanced growth which has been observed as an increase in the height of the plant, length and width of internode and has been substantiated by an increase in the bast fiber zone as seen from the histological studies. It is thus revealed that vermiwash could...
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Posted by admin on Jan 31, 2021 in |
An accurate, rapid economical, and simple, reliable assay method was developed and validated for the simultaneous estimation of Povidone-iodine and Ornidazole using RP-HPLC. In the proposed method, the efficient chromatographic separation was achieved using waters X-Bridge C8 column (150 × 2.1mm, 3.5µ) as a stationary phase and acetonitrile: 0.1% Orthophosphoric acid (50:50 v/v) as a mobile phase with a flow rate of 1 ml/min and UV detection was carried at 320nm. Chromatography was carried out isocratically at ambient temperature and the run time was 8 min. System suitability parameters were studied by injecting the standard six times, and results were well under the acceptance criteria. Linearity study was carried out between 10-150% levels, R2 value was found to be as 0.999. The precision of intermediate precision and method precision was found to be within the acceptable limit. By using the above method, assay of the marketed formulation was carried out and found to be within the limit. All the validation parameters as per ICH guidelines. Degradation studies of Povidone-iodine...
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Posted by admin on Jan 31, 2021 in |
Present study was planned to prepare a dorzolamide hydrochloride in-situ gel by using Carbopol 974 and HPMC K4M to reduce dosing frequency by increasing residence time as well as sustained drug release from the formulation in cul-de-sac. The concentration of both polymers was optimized by using 32 factorial designs with correlating its impact on dependent variables as cumulative in-vitro drug diffusion at the end of 8 h and viscosity at pH 7.4. Polymer composite showed a quadratic model for drug diffusion as well as for viscosity. Comparative in-vitro drug release study by using type II dissolution apparatus confirms sustained drug release characteristics of optimized formulation which showed 89.41% drug release at the end of 8 h as compared to a marketed formulation which showed complete drug release at the end of 3 h. Ex-vivo transcorneal permeability study ensured permeability of drug through the cornea. Histological study on goat eye cornea proved non-irritation potential of the prepared formulation. A comparative in-vivo study between optimized formulation and marketed formulation on normotensive...
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Posted by admin on Jan 31, 2021 in |
Introduction: Disorders of hyperpigmentation are difficult to treat, particularly in dark skin individuals. There is a dramatic enhancement of skin permeability of phytoconstituents due to their complexation with phospholipids. Complexation leads to better permeation through the skin, which is otherwise not possible. Research work focused on the development and evaluation of phos-phatidylcholine complexes of arbutin, having the issue of poor skin permeability as skin whitening agents. Materials and Methods: Arbutin, phosphatidylcholine, and petroleum ether have been used for the development of complexes. Authentication of arbutin has been performed by Fourier Transform Infrared study. UV–visible spectrophotometric method has been developed for estimation of arbutin followed by the development of complexes by rotary flask evaporation technique, preliminary trials for selection of dependent and independent variables, optimization of complexes by Box- Behnken reduced surface response design, evaluation of optimized batch by percentage entrapment efficiency, particle size, zeta potential, and in-vitro drug release study by Franz diffusion cell. Result and Discussion: Arbutin sample FTIR data and standard FTIR data are matched. Final polynomial...
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Posted by admin on Jan 31, 2021 in |
The present work evaluates the impact of alterable manufacturing and formulation factors on the physicomechanical properties of Acetaminophen (APAP); a poorly compressible Active Pharmaceutical Ingredient (API). By varying the amount of APAP and particle size of Microcrystalline Cellulose (MCC), six different formulations were prepared. These formulations were compressed into tablets at different compression pressures and speeds. The porosity of the tablets was evaluated through “out-of-die” Heckel analysis. Furthermore, the qualitative and quantitative relationships of (i) Percentage of APAP, (ii) Compression pressures, (iii) Compression speeds, and (iv) Particle size of MCC with tablet porosity were evaluated by principle component analysis (PCA) and principle component regression (PCR). Heckel analysis revealed that increasing the ratio of APAP to MCC in the formulation adds its compressibility when the MCC particle size is similar to that of APAP. While, using large MCC particle size increases the compressibility due to fragmentation of particles, using MCC of small particle size increases the compressibility to a higher extend. The PCA indicated that the percentage of APAP, compression...
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