Posted by admin on Oct 31, 2020 in |
The aim of the present investigation was to formulate and evaluate phytoformulation prepared from the ethanolic extract of Vernonia elaeagnifolia. Vernonia elaeagnifolia whole plant was collected and extracted with ethanol by soxhlation. Dried ethanolic extract of Vernonia elaeagnifolia was used to formulate the nanosuspension by homogenization method to enhance the bioavailability of phytoconstituents by increasing its solubility. Nano suspension of Vernonia elaeagnifolia (NS-VE, 50 mg/kg, 100 mg/kg) was evaluated for particle size, polydispersed index (PDI), entrapment efficiency, zeta potential, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC).NS-VE was screened for antihyperlipidemic activity with propylthiouracil induced and triton X-100 induced hyperlipidemia models in rats. The average particle size of NS-VE was found to be 0.027µm, PDI 60% (0.026 µm), 5mV zeta potential, and 46% entrapment efficiency. NS-VE (at doses 50 mg/kg, 100mg/kg bd.wt p.o) showed significant (p<0.01) anti-hyperlipidemic effect by reducing levels of TG, TC, LDL, VLDL and shown raised level in HDL when results were compared with normal control, disease control, and standard group. Nanosuspension of Vernonia elaeagnifolia...
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Posted by admin on Oct 31, 2020 in |
Diabetes mellitus is one of the major public health problems throughout the world. Current therapies, especially synthetic drugs, often fail to bring back normal glycemic control without complications. Numerous herbal medicines are widely explored as alternative medicine in diabetes. The objective of this work was to evaluate the antidiabetic activity of such herbal extracts of roots of Withania somnifera, Boerhaavia diffusa, and their combination in experimentally induced diabetic rats. Both plants are well known for their potential medicinal activities. The two plant extracts and their combination at a dose of 200 mg/kg/day were administered to dexamethasone-induced insulin-resistant animals for 10 consecutive days. Blood glucose levels, lipid profiles, and body weights were measured for the evaluation of their anti-diabetic effect. MEWS (p<0.05), MEBD (p<0.01), and their combination (p<0.001) showed a significant decrease in blood glucose levels in diabetic rats. In addition, both the extracts (p<0.05), (p<0.01), (p<0.05) (p<0.05) and their combination (p<0.01), (p<0.001), (p<0.001), (p<0.01) showed significant decrease in serum triglycerides, total cholesterol, VLDL levels, and an increase in HDL...
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Posted by admin on Oct 31, 2020 in |
The present work was aimed to evaluate the different properties of turmeric starch. Starch has been an endless subject of research for many years. It is an inexpensive, readily available compounds with considerable applications in the food as well as non-food. Turmeric starch was isolated from fresh rhizomes of Curcuma longa L. and Curcuma Caesia (Zingiberaceae). In this article, we established an easy and simple method of isolation of starch from the fresh rhizomes of turmeric species. Along with physical, physiochemical characteristics were studied like, microscopical analysis size and shape, particle size distribution (2-32 µm), molecular weight determination by gel permeation chromatography (GPC) (372267g/mol), pH of turmeric starch solution (5.6), specific surface area by BET analysis (0.69 m2/gm), moisture content (15%), true density (0.568 g/cm3), Iron content (less than 10 ppm), a viscosity of starch solution (1209 cP), and gelatinization temperature (80 °C), etc. Remarkably turmeric starch has shown less consistency than other starches and temperature-dependent gelatinization property within 20 min at 80 °C. The main aim of this...
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Posted by admin on Oct 31, 2020 in |
Ramganga river water is an important source of irrigation in major parts of the Moradabad and Bareilly region. The current study focuses on the assessment of the water quality of this river. River water samples were collected from five different sites of Moradabad and Bareilly stretch during the summer and winter season of the year 2018. Two sampling sites, namely MDA colony (S1) and Nawapuranalla (S2) were at Moradabad while the remaining three sites viz. UchaGaon (S3), Ramganga bridge (S4), and Chaubari village (S5) were at the Bareilly region. In summers, pH at S1 was highest while Total Solid (TS), Total suspended solids (TSS), biological oxygen demand (BOD) and chemical oxygen demand (COD) of river water observed highest at S2. However, in winters, dissolved oxygen (DO) at S1 observed highest while Total dissolved solids (TDS), Nitrate and Phosphate were highest at S2. The mean values of these parameters were compared with WHO and BIS standards and found that all parameters were within the permissible limit except BOD, COD, and...
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Posted by admin on Oct 31, 2020 in |
In general, ocular efficacy is strongly related to ocular drug bioavailability, which may be enhanced by prolonging precorneal drug residence time and increasing corneal drug penetration. Hence, the present study involves the development, characterization and evaluation of biodegradable moxifloxacin hydrochloride nano-particles intended for ocular use. Nano-particles were prepared by nano-precipitation technique using poly lactic-co-glycolic acid. 32 factorial designs were applied to optimize the drug formulation. The effect of independent variables such as drug-to-polymer ratio and speed of homogenizers on entrapment efficiency and particle size were investigated. Studies such as X-ray diffraction (XRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) were carried out on the selected formula. In-vitro release study showed extended drug release. Hen’s egg chorioallantoic membrane (HET-CAM) test was used for the evaluation of ocular tolerance, which showed the non-irritant efficacy of the developed formulation. These results express the applicability of encapsulating moxifloxacin hydrochloride biodegradable polymeric nanoparticles for ocular...
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