Posted by admin on Oct 31, 2020 in |
The present investigation deals with the development of the controlled porosity osmotic pump (CPOP) tablet of Garcinia indica fruit rind extract used in the management of colon cancer by implementing the concept of Quality by Design (QbD). The quality target product profile (QTPP) and Critical Quality Attributes (CQA) of the Garcinia indica tablets were defined based on preliminary studies. The effects of critical parameters were investigated by executing the design of experimentation (DOE) using 32 factorial design. The inclusion complexes of Garcinia indica and HP-βCD were added with an optimized amount of sodium chloride in the core of the tablet and coated with cellulose acetate. Multiple regression analysis and ANOVA were employed to identify and to estimate the effect of important parameters and establish their relationship with CQAs. The results of multiple linear regression analysis revealed that CPOP tablets should be prepared using an optimum % weight gain of the tablet (X1) and concentration of pore-forming agents in the coating (X2) to achieve a zero-order drug release. The contour...
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Posted by admin on Oct 31, 2020 in |
Ayurveda literally meaning the ‘science of life’ believes a completely normal state of health. Marma is one of the important sciences of treatment; described in the various ancient text of Ayurveda. The life force energy i.e. Prana is concentrated at the vital points in the body known as Marma. Urvi Marma is a Vaikalyakara type of Marma situated in the lower limb in the middle of the thigh, i.e., at the adductor canal and injury or trauma at this specific site causes Shonita Kshaya (hemorrhage) and Sakthi Sosha (wasting of limb). Structurally it is Sira Marma, and the area of this Marma is one Angula. The Adductor canal is a space in a muscle located on the medial side of the middle one-third of thigh. It extends from apex of femoral triangle above to the fifth osseoaponeurotic opening of adductor magnus below. Femoral vessels and saphenous nerve are the main contents of this canal. The peripheral nerve block in adductor canal is an important surgical operation procedure for knee...
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Posted by admin on Oct 31, 2020 in |
Wear particle evoked lysis limits the long-run survivorship of total joint replacement (TJR) in polygenic disease. Monocyte / macrophages area the key cells of this adverse reaction. The aim of this study was to come up with useful human osteoclasts (OCs) in-vitro from sort a pair of diabetes (T2D) and health management to research the potential osteoclastogenic role of T2D and implant detritus in implant rejection. Long-run sterile failures of joint replacements area usually attributed to implant detritus evoked inflammation and lysis. Unhealthy cytokines are shown to extend bone cell activity that suggests that monocyte/macrophage exposure to each metal particles and soluble metal ions within the bone-implant interface seemingly contribute to implant debris-induced inflammation and later lysis. The current study may give insight into the potential role of implant debris on the etiology of bone loss in T2D. It concludes that Peripheral blood mononucleate cells (PBMCs) are primed for increased proinflammatory activity in patients with T2D and plays a central role in the rejection of the implant by increasing...
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Posted by admin on Oct 31, 2020 in |
The study was aimed to justify the traditional claim of fruits of Sesbania grandiflora (Leguminosae) as a medhya rasayana. Dementia was induced with chronic administration of a high fat diet for 90 days. Petroleum ether, benzene, chloroform, acetone, ethanol extracts of fruits of Sesbania grandiflora were evaluated for cognition-enhancing activity in high-fat diet-induced dementia in rats using an elevated plus maze and biochemical estimation of brain AchE and cholesterol level. Piracetam (200 mg/kg p.o.) as standard drug. Transfer latency (TL) was observed in HFD induced rats using EPM which showed significant increase (p<0.01) in TL as compared to the normal control group. The high-fat diet-induced rats showed a significant increase (p<0.01) in AchE and cholesterol levels as compared to normal control. Whereas petroleum ether extract treated rats showed a significant increase (p<0.01) in AchE and cholesterol level. Treatment with benzene, chloroform, acetone ethanol extract of Sesbania grandiflora fruits inhibited the rise in brain acetylcholinesterase and cholesterol level. These observations established traditional claim, and thus Sesbania grandiflora could be memory...
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Posted by admin on Oct 31, 2020 in |
The present investigation was aimed at synthesis, characterization and in-vitro antibacterial and anticancer activities of synthesized gold nanoparticles using bark extract of Ceiba pentandra (L.) Gaertn. The synthesized AuNPs were confirmed by a UV-vis spectrometer through observing the surface plasmon resonance peak at 535 nm. Various other techniques, such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Selected area electron diffraction (SAED), and High- resolution transmission electron microscopy (HR-TEM) were also employed in the demonstration of the AuNPs properties. The synthesized gold nanoparticles were highly stable, spherical in shape, while other particles had irregular circles without uniform edges with average sizes of 20-48 nm. By using the agar well diffusion method, an attempt was made to evaluate the antibacterial activity of the metal nanoparticles against human pathogenic bacteria. AuNPs showed efficient antibacterial activity, which was found to be more pronounced against gram-negative bacteria than gram-positive ones. Through MTT assay, cytotoxicity effects of the synthesized AuNPs were tested against HCT-116 colon cancer cell lines with an IC50 inhibitory concentration...
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