Posted by admin on Dec 31, 2020 in |
Complementary alternative medicine focuses on discovering the potential of plants in prevention and management of chronic diseases. Although Morus species has been screened for various biological activities, studies reporting the pharmacological effects of Morus indica (MI) hybrid varieties viz., V1 and S36 is scarce. This study focused on screening the phytochemical composition of Morus indica V1 (MV1) and Morus indica S36 (MS36) and evaluate its antioxidant and anti-cancer potential. The qualitative analyses revealed the presence of all major phytochemicals except alkaloids. The results of the quantitative analyses showed a better phytochemical profile in MV1 than MS36 and the values differed significantly (p<0.05). The antioxidant activity was higher in methanol extracts of both the MI varieties followed by ethanol and aqueous extracts since the extractability of phytochemicals are higher in organic solvents. MV1 had a better phytochemical profile compared to MS36 and therefore was selected for screening the in-vitro anti-cancer properties. Among the methanol and aqueous extract of MV1, aqueous extract had the lowest IC50 value viz., 55 µg/mL. The...
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Posted by admin on Dec 31, 2020 in |
The comparative toxicological characteristic in-vitro and antimicrobial activity to perform stability tests of several linear medium-chain aliphatic monoperoxyacids (perC8–C12) and aliphatic diperoxyacid (diperC9) were studied. Substances of peroxide acids: perС8, perС10, perС12, diperoxyazelaic acid (diperC9) are in 5.6; 22.8; 64 and 1.6 times less toxic than reference substance – peracetic acid (perC2). New knowledge concerning а comparative antimicrobial activity of studied medium-chain aliphatic peracids and their thermal sensitivity was obtained. These fundamental stability studies resulted in the emergence of safe antimicrobic agents. Nonanebis(peroxoic acid) and Peroxyoctanoic acid were proposed as an agent in the chemical disinfection prosses for the first time. Medium-chain aliphatic peracids were demonstrated to be very robust. Sufficiently high bactericidal activity was achieved after relatively short exposition times (from 10 min to 2 h for spores of B. anthracoid), at near-ambient temperature (20 °C). In this work, it has been demonstrated how stability studies can underpin rational design of antimicrobic agents that in turn lead to a both safer and economically viable chemical disinfection and sterilization...
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Posted by admin on Dec 31, 2020 in |
The current work reports an ecofriendly approach to study morphological and biochemical responses of Pistia stratiotes L. (Water lettuce) were investigated. The assessment of morphological, biochemical parameters, and accumulation of chromium in free-floating macrophyte exposed at its various concentrations viz. 0.25, 0.50, 1.25, and 2.5 ppm of chromium at the regular intervals of 4, 8, and 12 days, respectively. Pistia showed morphological toxicity like withering of roots, chlorosis, and necrosis at higher concentrations (2.5 ppm) of chromium. However, the plant showed normal growth at a lower concentration of 0.25 and 0.50 ppm. The evaluation of biochemical parameters of test plants showed Total Chlorophyll, Carbohydrate, and Protein content was increased at lower concentrations (0.25 ppm) and decreased at higher concentrations (2.5 ppm) of chromium. The toxicity of chromium was found to be directly proportional to its concentration and duration of exposure. It is evident from the results that the accumulation of chromium can produce adverse effects on the morphology of test plant species at a higher concentration of chromium. This...
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Posted by admin on Dec 31, 2020 in |
Introduction: Human Norovirus (HuNoV) is the major cause of acute gastroenteritis in pediatric populations, accounting for approximately 18% of cases worldwide. The aim of this study was to determine the prevalence rate and characterization of genogroup in the pediatric population with gastrointestinal disease. Materials and Methods: A total of 205 fecal specimens were taken from children below 15 years of age with acute gastroenteritis disease. Samples were collected from the pediatric department of Sanjay Gandhi Post Graduate Institute of Medical Sciences, Luck now. RNA was extracted from fecal specimens and screened for Norovirus GI and GII genogroups using real-time PCR. Results: The overall rate of Norovirus infections was 23 (11.2%). Among patients positive for Norovirus, 17(74.0%) were identified as GII genogroup, and 6 (26.0%) were identified as GI genogroup. Conclusion: The majority of Norovirus associated viral gastroenteritis cases among children were attributed to GII genogroup. Younger patients were at more risk of acute gastroenteritis. As the viral transmission was evident by the oral-fecal route, the high positivity of clinical...
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Posted by admin on Dec 31, 2020 in |
Marine carbohydrates play a crucial role in drug development and disease eradication as it is suggested as a promising bioactive material for its various properties. Seaweeds are the marine macroalgal source that contains a large amount of sulfated polysaccharides. Sargassum wightii (S. wightii) is one of the seaweed which possesses a wide range of pharmacological actions. The aim of the present work is to qualitatively quantitatively analyze the phytochemical substances and screen the antibacterial activity of S. wightii. The study is accomplished with chloroform and methanolic extracts of S. wightii. Among this, methanolic extract of S. wightii shows the presence of more phytochemicals and a substantial antibacterial activity. Quantitative analysis showed the presence of flavonoid content more. Antibacterial activity was more for gram-negative bacteria. Analysis of phytochemical substances and antibacterial activity determination reflected significant results. Hence further observations and studies on this macroalgae could bring out promising results in the future for the welfare of...
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