Posted by admin on Dec 31, 2020 in |
Zingiber officinalis belonging to family Zingiberaceae is a plant of ancient cultivation that is traditionally used in several disorders. The principal components of ginger reported are gingerols, shogaols, and high content of starch (40 to 60 %). Not much work has been done on the separation of starch from ginger and its characterization. The main objective of this study was to investigate the potential of ginger starch to be used in Food, Pharma, as well as other industries. A simple, easy, convenient, and inexpensive method was designed to separate starch from ginger powder. The isolated ginger starch was then subjected to various physical and chemical characterization tests. The morphology of the starch granules (size and shape) was studied with scanning electron microscopy (SEM), which revealed oval and round forms of starch granules. Dynamic rheological properties of ginger starch were measured using Viscolead viscometer. The Molecular weight of starch was determined by Gel Permeation Chromatography (GPC) (1289858 g/mol). Ginger starch showed a gradual increase in swelling power and solubility index...
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Posted by admin on Dec 31, 2020 in |
Uncontrolled nausea and vomiting remain one of the greatest fears of patients undergoing therapy for cancer. In patients getting chemotherapy, serious nausea and vomiting may require dose reduction, treatment delay, or even permanent stoppage. Conventional therapy provides temporary relief from symptoms, but it has lots of undesirable side effects. Prochlorperazine is still widely used as an anti-emetic. Oral and parenteral delivery of prochlorperazine is useful in the management of nausea and vomiting, but due to short half-life, frequent dosing is required, which is inconvenient for the patient. The transdermal drug delivery system is a novel approach and substitute for oral drug delivery and parenteral delivery. It is an easy, painless, and convenient way of applying. In this work, an attempt was made to formulate and evaluate prochlorperazine containing transdermal patches by utilizing casting and solvent evaporation method. The main objective of formulating the Transdermal system was to prolong the drug release time, reduce the frequency of administration and to improve patient compliance. Formulated transdermal patches were evaluated for in-vitro...
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Posted by admin on Dec 31, 2020 in |
This study was aimed to identify the possible bioactive chemical constituents of the state tree of Rajasthan, i.e., Prosopis cineraria L. (locally called Khejri) by GC-MS analysis using the GC-MS equipment (Shimadzu GCMSQP2010). For this purpose, the ethanolic extract of P. cineraria pods were used. Experimental conditions of the GC-MS system were as follows: Rtx-5MS capillary standard non-polar column, dimension: 30m, ID: 0.25 mm, Film: 0.25 µm was used, and flow rate of mobile phase (carrier gas: He) was set at 1.0 ml/min. Crude samples that were dissolved in methanol were run fully at a range of 40-550 m/z, and the results were compared by using NIST Library. GC-MS analysis of an ethanolic extract of pods led to the identification of 32 compounds viz. Bicyclo[3.1.1]hept-3-ene, 4, 6, 6-trimethyl-2-vi (30.47%), 5-Isopropyl-2methylbicyclo [3.1.0] hexan-2-ol(19.38%), (-)-.beta. –Bourbonene (10.62%), 3-O-Methyl- d-glucose (5.04%), Kessane (4.01%), Thunbergol (3.65%), alfa.-Copaene (2.23%). There is not much information available on the phytochemical constituents of P. cineraria pods. This is the first attempt to investigate the GC-MS analysis of...
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Posted by admin on Dec 31, 2020 in |
Plant drugs enjoy much acclaim and worldwide acceptability even in the midst of amazing advancements in modern medicine. Current research in drug discovery from medicinal plants involves an approach combining botanical, phytochemical, and pharmacological techniques. In the present study, we selected the root bark of the plant Artocarpus heterophyllus Lam. belonging to the family Moraceae, to establish its phytochemical constituents, antioxidant property, and cytotoxic activity. Phytochemical evaluation of the total ethanolic extract (TEE) obtained showed the presence of alkaloids, glycosides, phenolic, flavonoids, amino acid, terpenoids, etc. The TEE was fractionated using solvents in the increasing order of polarity, i.e., petroleum ether, chloroform, and ethyl acetate. The antioxidant studies were conducted by DPPH and ABTS methods on chloroform extract (CE) and ethyl acetate extract (EAE) of the root bark of A. heterophyllus Lam. The extract which showed the greatest antioxidant property (EAE) was selected for cytotoxic studies using the MTT method on HL60 (Human promyelocytic leukemia) cell lines. Both the antioxidant and cytotoxic activity studies showed promising...
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Posted by admin on Dec 31, 2020 in |
The present study is designed to investigate the hepatoprotective effect of Hydrilla verticillata on lead-induced hepatic damage in freshwater fish. The fish were treated with a sub-lethal concentration of lead acetate to induce liver damage and fed with supplementary feed containing 20% of hydrilla dry powder. After 21 days of treatment, the liver was removed, and hepatotoxicity and its prevention were analyzed. Liver marker enzymes like alanine transaminase (ALT), aspartate transaminase (AST), acid phosphatase (ACP) were measured and compared with the control. Histopathological study of the liver was done to find out the protective effect of Hydrilla verticillata. The lead-induced hepatotoxicity by stimulation of ALT, AST, ACP and represented by degeneration of hepatocytes and formation of cytoplasmic vacuoles. Hydrilla verticillata supplementation significantly (p ˂ 0.05) reduced the level of hepatic enzymes and showed a protective effect on hepatocytes by normalization of degenerated and fibrotic liver tissue as of control. This study strongly confirms the hepatoprotective effect of Hydrilla verticillata against lead-induced acute liver toxicity. Hydrilla verticillata could be recommended...
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