Posted by admin on Jan 31, 2025 in |
Introduction: Abnormal uterine bleeding (AUB) is a common gynecological concern that presents significant diagnostic challenges, particularly because it encompasses a wide range of possible underlying causes, from benign conditions like polyps and fibroids to more serious pathologies such as endometrial cancer. This study aimed to assess the diagnostic accuracy of hysteroscopy in AUB and its concordance with histopathological findings. Materials and Methods: Fifty consecutive women, aged 30-70 years, with AUB were prospectively enrolled. Each underwent hysteroscopy followed by dilatation and curettage (D&C). Clinical data, hysteroscopic findings, and histopathological analysis of endometrial samples were systematically recorded and analyzed. Results: The average age of participants was 43.8 years, with endometrial polyps being the most common abnormality detected on hysteroscopy, accounting for 30% of cases. Hysteroscopy demonstrated 100% sensitivity and 92% specificity. Histopathology, however, missed 10% of polyps and 4% of hyperplasia cases. Mild anemia was present in 66% of patients, indicating potential blood loss due to AUB. Conclusion: Hysteroscopy showed a high diagnostic yield for structural causes of AUB, particularly in...
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Posted by admin on Jan 31, 2025 in |
Siddha science is an ancient way of healing which uses plants, minerals and metals for medicinal preparation. Research on herbs is gaining significant interest for discovering new drug molecules. In this context, it is essential to investigate the numerous traditional formulations documented in classical Siddha literature. The Thurinji manapagu contains Citrus medica and Saccharum officinarum is a traditional herbal syrup formulation which is indicated for nausea and vomiting, hypertension in clinical practice of siddha. The phytochemical analysis and free radical scavenging effect of the Thurinji manapagu was studied in this paper to explore the antioxidative efficacy of the drug. The qualitative phytochemicals of Thurinji manapagu was determined by standard protocols. The scavenging effect against the free radicals of the drug Thurinji manapagu was measured by the following in-vitro methods: DPPH radical scavenging assay, H2O2, ABTS, NO scavenging assay and studied through U.V spectrophotometer. The phytochemical screening of drug reveals the presence of phenols, tannins, saponins, coumarins etc. The results of the antioxidative capacity of the drug on all four...
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Posted by admin on Jan 31, 2025 in |
Allergic conjunctivitis (AC) is a prevalent ocular condition characterized by inflammation of the conjunctiva due to allergen exposure, resulting in itching, redness, and discomfort. Traditional medicinal plants such as Ginkgo biloba and Aegle marmelos have been recognized for their potential anti-inflammatory and anti-allergic properties. In this study, we conducted an in-silico analysis to explore the therapeutic potential of phytochemicals derived from Ginkgo biloba and Aegle marmelos against AC. First, we compiled a list of phytochemicals in Ginkgo biloba and Aegle marmelos, focusing on compounds known for their anti-inflammatory and immunomodulatory activities. Molecular docking studies were performed to investigate the binding interactions between these phytochemicals and key proteins implicated in the pathogenesis of AC, including histamine receptors, inflammatory cytokines, and enzymes involved in the allergic response. Virtual screening techniques were employed to identify potential lead compounds with high binding affinities and favorable pharmacokinetic properties. Additionally, ADME/T properties were predicted to assess the bioavailability, metabolic stability, and potential toxicity of the selected phytochemicals. In-silico findings suggest that certain phytochemicals from Ginkgo...
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Posted by admin on Jan 31, 2025 in |
Liver is an important organ and a central one for many of the metabolic functions of the body, decomposition of toxic and waste substances, and disposal of harmful substances from the body. Liver illnesses are still the serious problem of human health. Canna indica commonly known as an Indian shot, extensively used as a nutritive agent & has a number of valuable pharmacological activities. People find its place in Ayurvedic Pharmacopoeia of India, but attempts have not made to describe the hepatoprotective activity of this plant. The present work emphasizes the comprehensive ethano-medicinal uses of Canna indica root to enlighten its phytochemical constituents and hepatoprotective activity of this plants. To authenticate the traditional medicinal claim of investigation has been undertaken to evaluate the hepatoprotective activities of Canna indica plant. Administration of paracetamol and different extracts of Canna indica showed no mortality or morbidity in the animals during the period of study. The values of AST, ALT, ALP, and total bilirubin were all substantially raised by paracetamol. Significant hepatoprotective effects...
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Posted by admin on Jan 31, 2025 in |
Background: Acute gastroenteritis is usually considered – a benign disease, remains a major cause of pediatric morbidity and mortality around the world. Materials and Methods: An observational cross-sectional study conducted in indoor / outdoor patient department of Pediatrics in Government Medical College and Rajindra Hospital, Patiala for 6 months. Demographic data and complete prescriptions of patients suffering from acute gastroenteritis (age >1month to 6 years) were collected and analyzed by using five World Health Organization Core prescribing indicators. Categorical data was analyzed by chi-square test and quantitative data was analyzed by descriptive method. Prevalence of disease was calculated. Results: In total 60 patients, male patients (58.33%) were found to be more infected than female patients (41.67%). In age group of 0-2 years more males 82.86%, and in age group of 2-5 years and 5-6 years more females i.e., 80% and 12%, respectively were found to be infected with acute gastroenteritis. Most prescribed class of drug was drugs acting on gastrointestinal tract (51.46%) followed by fluid & electrolytes (22.7%), antimicrobials...
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