Posted by admin on Aug 31, 2020 in |
The present study has been undertaken to evaluate the association between serum uric acid levels as a marker of iron overload in Saudi people. A retrospective cohort study was carried out at King Fahad Medical City in the Riyadh-central region of the Kingdom of Saudi Arabia for four months from 1st November 2018 to the end of February 2019 on the random sample of 117 medical files for Saudi patient of both genders. All the obtained data were analyzed by the SPSS program by considering various variables like serum uric acid, transferrin, hemoglobin, ferritin level, etc., in between hyperuricemic non-hyperuricemic patients. Serum uric acid, transferrin, ferritin, and hemoglobin levels were significantly (p>0.05) high i.e. 564.1 ± 127.7 vs. 417.6 ± 38.3 μmol/l; 3 ± 1 vs. 2.1 ± 0.8 g/dl; 658.9 ± 896 vs. 528.6 ± 920 ng/ml; 9.9 ± 2.2 vs. 9.7 ± 1.8 g/dl in hyperuricemic and non-hyperuricemic patients respectively. Pearson correlation between serum uric acid and hemoglobin, ferritin level, transferrin level indicate positive correlation (r =...
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Posted by admin on Aug 31, 2020 in |
Herbal medicines play an important role in cancer prevention. Mangroves have been used worldwide due to the presence of various bioactive metabolites in it. The specific medicinal properties of Rhizophora mucronata have been an interest in preventing breast cancer. Mangroves Rhizophora mucronata belongs to family Rhizophoraceae. The leaf extract reveals various roles in folk remedies to treat various diseases. This analytical study aims to find out various phytochemical and components present in the leaf extract by the GC-MS technique. The methanol leaf extract revealed the presence of phytochemicals like saponins, flavonoids, alkaloids, quinines, glycosides, cardiac glycosides, terpenoids, phenols, coumarins, and steroids. The GC-MS analysis provided nine different compounds like Phenol, 2, 4-bis (1,1-dimethyl ethyl)- (28.2%), Flavone- (66.9%), 4H-1-benz0pyran-4-one,7-hydroxy-2phenyl (39.8%), Chrysin (100%), 4H-1 Benzopyram-4-one, 7-hydroxy-2-phenyl-(100%), 5,8 Octadecadienoicacid, methyl ester-(55.8%), Phytol- (31.8%), Coumarine, 3-(2,4-dinitrophenyl)-(31.3%), Elaidic acid, isopropyl ester-(9.2%). Further purified compounds are used in the pharmacological industry against breast cancer and reduce the side effects and pains during the treatment of...
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Posted by admin on Aug 31, 2020 in |
The bioactive peptides derived from food have increased consideration for their function in averting numerous chronic diseases, comprising, diabetes and obesity. Edible insects are the feasible composition of bioactive peptides owing to their high protein content and viable production. The present study was aimed to evaluate the antidiabetic and anti-obesity effects of seven edible insects’ protein hydrolysates after simulated gastrointestinal enzymatic digestion. Antidiabetic and anti-obesity efficiency was determined by the inhibition of digestive enzymes viz., dipeptidyl peptidase-IV, α-glucosidase, and α-lipase activity. Three active protein hydrolysate extracts (1.25, 2.5, and 5mg/dl) were selected and analyzed in terms of their IC50 values, and all tested extracts inhibited those enzyme activities in a dose-dependent manner. Based on the present study, we conclude the seven edible insects’ hydrolysate have potential enzyme inhibitory activities and thereby proved as an antidiabetic and anti-obesity...
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Posted by admin on Aug 31, 2020 in |
Objective: We report the phyto-pharmacognostic evaluation and HPTLC finger-printing profile of the methanolic extract of Saptaparṇa [Alstonia scholaris (L.) R. Br.] leaves – unaffected and gall-affected, collected in January 2019. Materials and Methods: Physicochemical parameters and phytochemical screening were done by standard procedures. HPTLC finger-printing profile of the methanolic extracts of dried leaves and dried leaves with gall was performed on pre-coated TLC silica gel 60F254 plates with hexane: EtOAc: MeOH: formic acid (5:4.5:0.5:0.5 v/v) as developing solvent, with observation at 254 and 366 nm. Results: Some of the leaves had 15-20 galls on both surfaces. Powder Microscopy of the bitter-tasting green color leaf powder showed a group of epidermal cells, unicellular trichomes, elongated stone cells in the group, prismatic calcium oxalate crystals, single-layered fibers, reticulate vessels, anomocytic stomata, and reddish-brown color tannin matter; epidermis of gall cells, insect body in affected leaves. Phytochemical screening revealed the presence of alkaloids, carbohydrates, terpenoids/steroids, phenolic compounds/ tannins, but an absence of reducing sugars and flavonoids. A large number of bands were...
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Posted by admin on Jul 31, 2020 in |
The purpose of current research work has been made to formulate a gastro-retentive drug delivery system (GRDDS) of those drugs having a narrow absorption window or having good absorption at the proximal part of the gastrointestinal tract (GIT) to deliver at stomach site and to improve the bioavailability of a drug. Gastro-retentive hydrogel tablet of Cefixime trihydrate was prepared by the direct compression method via using carbopol 940 and chitosan with different concentrations. Cefixime is a very poorly water-soluble drug after its oral administration so that it is slowly and incompletely absorbed from the gastrointestinal tract, which results within poor bioavailability i.e., 40-50%. Hydrogel was characterized concerning diverse parameters with mechanical strength, swelling ratio, in-vitro drug release, etc. The drug release from a combination of carbopol 940 and chitosan-based hydrogel showed for a prolonged period. A 32 full factorial design was utilized to optimize the tablet of cefixime trihydrate by selecting an amount of carbopol 940 and chitosan as independent variables and effects were observed on drug release and...
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