Posted by admin on Oct 31, 2020 in |
Helicobacter pylori causative agent of acid peptic disease is a microaerophilic, spiral-shaped, gram-negative bacteria found in the gastric epithelium that may also lead to complications such as chronic gastritis, mucosa-associated lymphoid tissue (MALT) lymphoma, gastroduodenal ulcer and adenocarcinoma in stomach. Plantbioactives have always been potential therapeutics. Usage of modern bioinformatic tools plays a vital role in exploiting the potentials of alternative therapeutic molecules in managing diseases like peptic ulcers and their complications. The in-silico evaluation was carried out using molecular docking of the quorum sensing proteins of H. pylori with the ligand β-sitosterol obtained from the silver nanoparticles of Acorus calamus L. Among several given quorum sensing proteins the molecular interaction with the ligand β-sitosterol showed a high binding affinity with DnaA, PhnB, ToxB and Sip proteins. The results obtained from molecular interaction study revealed that the ligand β-sitosterol will be readily taken up by the organism, thereby facilitating easy inhibition or inactivation of quorum sensing molecules ToxB, DnaA, PhnB, and Sip, making it a novel therapeutic alternative to treat H....
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Posted by admin on Oct 31, 2020 in |
Background: Chronic suppurative otitis media (CSOM) is defined as a persistent infection of the middle ear cleft with a perforated tympanic membrane and draining exudate for more than 6weeks. Information about the organism responsible for COSM and their antibiotic susceptibility is important for effective treatment. Material and Methods: A prospective cross-sectional study was conducted on 85 patients; the middle ear discharge sample was collected under strict aseptic conditions and antibiotic susceptibility done as per Clinical Laboratory Standards Institute guidelines. Result: 85 ear swabs were collected, and 89 bacterial isolates were identified, of which 72.94% sample with mono-microbial growth, 16.47% with polymicrobial growth, 9.41% show no growth, and the rest 1.17% was a contaminant. Among 89 isolates, 39.33% were Gram-positive, while 60.67% were Gram-negative bacteria. The most common isolates were Pseudomonas species 40.45% followed by methicillin sensitive staphylococcus aureus (MSSA) 38.20% and others 21.35%. Pseudomonas species showed 100% susceptible to colistin, linezolid, imipenem, amikacin (97%); ciprofloxacin (92%); gentamicin (95%); Ceftriaxone (83%); meropenem (93%); Netilmicin (98%) and Sulfamethoxazole and Trimethoprim(SXT) (90%)....
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Posted by admin on Oct 31, 2020 in |
The present investigation deals with the development of the controlled porosity osmotic pump (CPOP) tablet of Garcinia indica fruit rind extract used in the management of colon cancer by implementing the concept of Quality by Design (QbD). The quality target product profile (QTPP) and Critical Quality Attributes (CQA) of the Garcinia indica tablets were defined based on preliminary studies. The effects of critical parameters were investigated by executing the design of experimentation (DOE) using 32 factorial design. The inclusion complexes of Garcinia indica and HP-βCD were added with an optimized amount of sodium chloride in the core of the tablet and coated with cellulose acetate. Multiple regression analysis and ANOVA were employed to identify and to estimate the effect of important parameters and establish their relationship with CQAs. The results of multiple linear regression analysis revealed that CPOP tablets should be prepared using an optimum % weight gain of the tablet (X1) and concentration of pore-forming agents in the coating (X2) to achieve a zero-order drug release. The contour...
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Posted by admin on Oct 31, 2020 in |
Ayurveda literally meaning the ‘science of life’ believes a completely normal state of health. Marma is one of the important sciences of treatment; described in the various ancient text of Ayurveda. The life force energy i.e. Prana is concentrated at the vital points in the body known as Marma. Urvi Marma is a Vaikalyakara type of Marma situated in the lower limb in the middle of the thigh, i.e., at the adductor canal and injury or trauma at this specific site causes Shonita Kshaya (hemorrhage) and Sakthi Sosha (wasting of limb). Structurally it is Sira Marma, and the area of this Marma is one Angula. The Adductor canal is a space in a muscle located on the medial side of the middle one-third of thigh. It extends from apex of femoral triangle above to the fifth osseoaponeurotic opening of adductor magnus below. Femoral vessels and saphenous nerve are the main contents of this canal. The peripheral nerve block in adductor canal is an important surgical operation procedure for knee...
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Posted by admin on Oct 31, 2020 in |
Wear particle evoked lysis limits the long-run survivorship of total joint replacement (TJR) in polygenic disease. Monocyte / macrophages area the key cells of this adverse reaction. The aim of this study was to come up with useful human osteoclasts (OCs) in-vitro from sort a pair of diabetes (T2D) and health management to research the potential osteoclastogenic role of T2D and implant detritus in implant rejection. Long-run sterile failures of joint replacements area usually attributed to implant detritus evoked inflammation and lysis. Unhealthy cytokines are shown to extend bone cell activity that suggests that monocyte/macrophage exposure to each metal particles and soluble metal ions within the bone-implant interface seemingly contribute to implant debris-induced inflammation and later lysis. The current study may give insight into the potential role of implant debris on the etiology of bone loss in T2D. It concludes that Peripheral blood mononucleate cells (PBMCs) are primed for increased proinflammatory activity in patients with T2D and plays a central role in the rejection of the implant by increasing...
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