Posted by admin on Sep 30, 2020 in |
Forskolin is a heterocyclic labdane-type diterpenoid extracted from the roots of the plant of Coleus forskohlii (Lamiaceae) has been studied in depth for its broad range of pharmacological properties. Coleus forskohlii aids in the control of pestilence of Uzi fly, Exorista sorbillans, and Exorista bombycis one of the gravest ecumenical pests in sericulture industry. Forskolin affected moulting; development and metamorphosis of Uzi fly and induced various types of morphological abnormalities in Uzi fly. The treated resultants of fifth instar Uzi fly maggots, a few of them died during moulting, some of them developed into maggot-pupal and pupal-adult intermediates, abnormal pupae, abnormal adults and remaining treated fifth instar maggots developed into morphologically normal adults exhibiting reduced fecundity when compared to the controls. Coleus forskohlii root extract (CFRE) exhibited growth-regulating activity on the Uzi fly. They affected pupal- adult transformation and produced intermediates along with ovarian deformities deformed adults and also affected the inhibition of pupation and adult emergence. The plant extract repressed the growth and development suggesting its use for...
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Posted by admin on Sep 30, 2020 in |
Quality is the most important requirement in the manufacturing process for every pharmaceutical and healthcare industry. All the drugs must be manufactured to the highest quality level. Quality cannot be guaranteed just by end-product testing, but we have to control each critical step carefully during the manufacturing process. This qualification and computer system validation plays an important role in controlling each critical step of application in order to maintain the quality of the final product. Computer system validation involves a series of activities that are taking place during the life cycle of processes. It also involves careful planning of various stages in the qualification and validation of application/software used in the manufacturing process, and all the work should be carried out in a structured way according to standardized working procedures. The objective of this work is to overview the qualification and computer system validation of instrument/equipment used in the pharmaceutical...
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Posted by admin on Sep 30, 2020 in |
The objective of the present study is to develop a colon targeted drug delivery system by using sodium alginate as a carrier for Mesalamine. Matrix tablets containing various excipients and sodium alginate were prepared by wet granulation technique using different binder systems. The prepared tablets were evaluated for hardness, weight variation, drug uniformity, friability, and in-vitro drug release study. The surface of the device of the best formulation was coated with Eudragit S100 to ensure that the device was more pH-dependent and trigger the drug release only at higher pH. The matrix tablet containing sodium alginate as a carrier and hydroxypropyl methylcellulose as a binder was found to be suitable for targeting mesalamine for local action in the colon as compared to other matrix tablets containing different binders. Matrix tablets containing sodium alginate released 97-99% of mesalamine in the simulated colonic fluid. The stability study for prepared tablets at 40 ºC/75% relative humidity for three months showed no significant change in the in-vitro drug release pattern. The results of...
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Posted by admin on Sep 30, 2020 in |
Herbal medicines play an important role in cancer prevention. Mangroves have been used worldwide due to the presence of various bioactive metabolites in it. The specific medicinal properties of Rhizophora mucronata have been an interest in preventing breast cancer. Mangroves Rhizophora mucronata belongs to family Rhizophoraceae. The leaf extract reveals various roles in folk remedies to treat various diseases. This analytical study aims to find out various phytochemical and components present in the leaf extract by the GC-MS technique. The methanol leaf extract revealed the presence of phytochemicals like saponins, flavonoids, alkaloids, quinines, glycosides, cardiac glycosides, terpenoids, phenols, coumarins, and steroids. The GC-MS analysis provided nine different compounds like Phenol, 2, 4-bis (1,1-dimethyl ethyl)- (28.2%), Flavone- (66.9%), 4H-1-benz0pyran-4-one,7-hydroxy-2phenyl (39.8%), Chrysin (100%), 4H-1 Benzopyram-4-one, 7-hydroxy-2-phenyl-(100%), 5,8 Octadecadienoicacid, methyl ester-(55.8%), Phytol- (31.8%), Coumarine, 3-(2,4-dinitrophenyl)-(31.3%), Elaidic acid, isopropyl ester-(9.2%). Further purified compounds are used in the pharmacological industry against breast cancer and reduce the side effects and pains during the treatment of...
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Posted by admin on Sep 30, 2020 in |
Adaptation of marine actinobacteria to extreme climatic conditions such as high salinity, high pressure and high temperature has modified their physiological conditions to survive and elaborate novel bioactive metabolites. Among the different actinobacterial strains isolated from coastal regions of Guntur District, Andhra Pradesh, India, one potent strain with broad-spectrum antagonistic activity was found and identified as Streptomyces rectiverticillatus VJMS-8. Attempts were made to optimize the cultural parameters for an enhanced yield of antimicrobial metabolite production. Production of bioactive metabolites by the strain was high in tryptone yeast extract dextrose broth as compared to the other media tested. The strain utilized galactose and tryptone as good carbon and nitrogen sources for the elaboration of bioactive metabolites. The optimum temperature and pH for bioactive metabolite production by the strain were recorded as 35 °C and 7.0, respectively. NaCl @ 5% supported high pro-duction of bioactive metabolites. The secondary metabolites produced by the strain grown under optimal conditions exhibited high antagonistic activity against a variety of gram-positive and gram-negative bacteria as well...
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