Posted by admin on Jun 30, 2020 in |
The recent work is based on the extraction and purification of natural gum from the bark of plant Terminalia elliptica (local name – Saaj) and the use of this gum to prepare pulsatile Drug Delivery System of Atenolol for the chronotherapy of cardiovascular diseases. Three formulations CF1, CF2, CF3 of core tablets were prepared by direct compression technique by varying concentrations of crospovidone and evaluated. Formulation CF3 showed the highest 98.71% of drug release after 30 min was selected for press coating. Press coated tablets of Formulation F1 to F5 were prepared by direct compression technique using varying combinations of Saaj gum and Ethylcellulose in the ratio of 1:0, 3:1, 1:1, 1:3 and 0:1 respectively by taking CF3 as core in all. The extracted gum, powder blends, core tablets, and press coated tablets all were evaluated for their physicochemical properties. From the dissolution study of formulation F1 To F5 it was found that F2 having 3:1 combination of Saaj gum and EC shows a significant lag time of around...
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Posted by admin on Jun 30, 2020 in |
The folk population of Gurguripal has mycophilic inclination, and wild mushrooms play a significant role in sustaining their livelihood. Explorative survey work was undertaken to document the ethnomycological knowledge of wild mushrooms occurring in forest areas of Gurguripal. In the present study, 166 informants from 9 villages were interviewed and information was collected through semi-structured questionnaires and interaction based on local name, edibility, medicinal applicability, preparation, and mythological beliefs among native tribal communities of this region. Santal, Munda, and Sabar are dominating schedule tribes in consuming wild edible mushrooms as food or dietary supplement. A total of 23 predominant mushroom species belonging to 16 families were screened. Among them, 19 species were effectively used against different human ailments by the traditional healers. In particular, Termitomyces heimii, Pleurotus ostreatus, Auricularia auricula, and Ganoderma lucidum have shown higher use values and manifold nutraceutical potentials. An Amanitaceous mushroom, namely Amanita bisporigera has been reported the first time herein as edible and recently sold in local markets. The present study enlightens the exploration...
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Posted by admin on Jun 30, 2020 in |
Feronia limonia (F. limonia) is an underutilized edible fruit commonly known as kaitha. The study was performed to compare the effect of three solvents at different concentrations on antioxidant activities of F. limonia fruit. Fruits were extracted in different solvents viz., ethanol, methanol, and acetone at concentrations of 50%, 70%, and 90%. Each extract was analyzed for total phenol and flavonoid content and their antioxidant activities such as Free radical scavenging activity (DPPH), Ferric reducing antioxidant power (FRAP), Metal chelating activity and reducing capacity (RC). The results indicate that 70% aqueous acetone works best for the extraction of TPC (35.60 mg GAE/g), TFC (31.69 mg QCE/g), and other antioxidant activities. The phenol and flavonoid content showed a significant correlation with antioxidant activities. The findings of the study suggested that F. limonia fruit is a good and cheap source of natural antioxidant which can serve as a functional food. The fruit possesses potent enormous health benefits and thus may be used in food and pharmaceutical applications....
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Posted by admin on Jun 30, 2020 in |
This study is aimed at investigating both the Gram-positive and the Gram-negative bacteria of ear swabs and their antibiotic susceptibility pattern. Ear samples of one hundred (100) subjects using sterile swab sticks were collected. Sixty-seven (67) out of 100 samples collected yielded growth when incubated at 37 ºC for 24 h. Microbiological tests were carried out to characterize the bacterial isolates. Kirby-Baur disk diffusion method was employed for antibiotic sensitivity testing. Results showed 67 isolates; Staphylococcus aureus 39 (58.2%): Streptococcus pyogenes (17.9%) and Pseudomonas aeruginosa (23.9%). The result obtained also showed incidence rates of Gram-positive and Gram-negative organisms to be 76.1% and 23.9%, respectively. The isolates demonstrated varying susceptibility patterns. Gram-negative organisms showed the highest susceptibility to Augumetin (93.8%) and Chloranphenicol (87.5%), while the Gram-positive organisms showed the highest susceptibility to Ceftriaxone (80.4%) and Ciprofloxacin (84.3%). Both Gram-positive and Gram-negative organisms showed the lowest susceptibility to Amoxicillin at 52.9% and 56.3%, respectively. It revealed that the bacterial isolates present had low susceptibility to generally available drugs; this leaves health...
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Posted by admin on Jun 30, 2020 in |
Gelling agents such as Carbopol 934 and HPMC K 100 were used in different concentrations for the preparation of Topical polyherbal extract gel formulations containing (%w/w) Eclipta alba, Hibiscus rosa-siensis, Trigonella foenum-graecum Linn. Prepared gel extract of various herbal ingredients were characterized by different parameters like gelling capacity, pH, Homogeneity, Grittiness, Extrudability, Spreadability, and Viscosity. Satisfactory results were obtained after determining the above physicochemical parameters. The release data of all designed polyherbal extracts were compared with the marketed product (2% Minoxidil) to examine marketing feasibility and formulation PG1 was shown similarity with Standard (2% Minoxidil). Hence, the designed formulation will be a good alternative for available marketed products with low...
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