Posted by admin on Jul 31, 2020 in |
The aim is to design, develop & characterize a desired gastro retentive super porous hydrogel (SPH) formulations containing lafutidine is histamine H2-receptor antagonist that may be used alone or with other agents to treat inhibits stomach acid production. SPH‘s synthesized employing various composite agents viz., sodium alginate, pectin, Carbopol, and chitosan were subjected to density and swelling property (swelling time, swelling ratio) characterization. Pectin, Carbapol, and chitosan have shown the best results; they were optimized for further characterization. As a hybrid agent is responsible for maintaining the capillary structure required for fast swelling of SPH, the effect of optimized hybrid on mechanical characters and swelling behavior of SPH was assessed. As the hybrid chitosan concentration increased, there was an extensive variation in swelling properties. Swelling time was gradually decreased from 45 to 16 min. SPHH-CN1 to SPH-CN7 lafutidine combined formulations were developed with dried SPH-CN5 powder. Drug release studies for formulations F1- F7 was carried out, and based upon release and retarding capacity, the effect of sodium bicarbonate F4...
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Posted by admin on Jul 31, 2020 in |
Background: The liver is the major detoxification organ that deactivates and removes toxic chemicals. The oxidative stress-mediated toxicity of chemicals involves destruction primarily to liver tissue (Hepatotoxicity), which could lead to cancer. Diosgenin, a steroidal sapogenin, is reported to be an apoptosis inducer, antineoplastic and antioxidant. The present study is aimed to screen diosgenin for its effect on diethylnitrosamine induced hepatotoxicity in rats. Materials and Methods: 48 male Wistar rats were divided into 6 groups of 8 animals each. Group 1: the vehicle was given to the animals for 8 weeks. Group 2: den control, group 3 sorafenib, groups 4, 5, and 6 diosgenin (10, 20, and 40 mg/kg, respectively). Groups 2 to 6 were administered with 0.01% den in drinking water for 8 weeks. The respective treatment started from 4th week and continued till the 11th week. At the end of the study, animals were sacrificed for the determination of biochemical, antioxidant, and histological parameters. Results: Administration of den caused a significant increase in the levels of serum...
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Posted by admin on Jul 31, 2020 in |
Filicium decipiens belongs to the Sapindaceae family, which is commonly known as fern tree, is found in the Western Ghats of southern India, small highland areas of East Africa and Sri Lanka and it is a medium to a large evergreen tree. It is commonly cultivated in gardens and roadsides as ornamental, noise barriers and windbreak plant. Filicium decipiens traditionally used for the treatment of diabetes in India. The leaves of Filicium decipiens have been collected from the Western Ghats of southern India, shade dried and powdered well. The finely powdered leaves have been extracted with petroleum ether, chloroform, methanol and water successively with an increase in polarity. The methanolic extract was column chromate-graphed using silica gel G 100-200 mesh to get brown color crystalline solid, which was analyzed for the presence of bioactive chemical constituents using Gas chromatography-mass spectrometry (GC-MS) technique. GC-MS analysis revealed the presence of thirty chemical constituents. The four different crude extracts (petroleum ether, chloroform, methanol and water) of leaves of Filicium decipiens have been...
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Posted by admin on Jul 31, 2020 in |
The present study aimed to determine the pharmacognostical evaluation and phytochemical analysis of the plant part of Lagersreomia speciosa. In this study, a macroscopical, microscopical evaluation was done. Various quantitative parameters such as total ash, acid insoluble ash, water-soluble ash sulphated ash, extractive value with various solvent were done. In the preliminary phytochemical analysis, various chemical test were performed for the determination of phytoconstituents present in the plant. Fluorescence analysis of powder drugs was done in a deferent wavelengthrange. TLC was performing for the methanolic extract taking the solvent system with various ratios. From the experiment result it was found leaves are bitter in taste, the shape is elliptical to oblong, acute base subacute apex, entire margin and pinnate venation the leaves are dorsiventral, long epidermis layer, spongy mesophyll, loosely packed parenchyma cell present in the leaf. Microscopic powder drug analysis shows the prism and rosette shape calcium oxalate crystals, lignified and annular xylem vessels, and multicellular trichomes. From quantitative microscopic study stomatal number, vain-islet number, vein termination number...
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Posted by admin on Jul 31, 2020 in |
To investigate the possible protective effects of satwa from three Tinospora species against acetaminophen and alcohol-induced hepatotoxicity in rats. Male albino wistar rats were divided into six groups (n=6); healthy control, negative control (Acetaminophen 1000mg/kg b.w./day, p.o. or 30%; alcohol 1ml/100g b.w./day, p.o.), positive control (Silymarin; 100mg/kg b.w./day, p.o.), Treatment 1 (Tinospora cordifolia satwa; 200mg/kg b.w/day p.o.), Treatment 2 (Tinospora sinensis satwa; 200mg/kg b.w/day, p.o.) and Treatment 3 (Neem-giloe satwa; 200mg/kg b.w/day., p.o.). Liver injury in the rats was induced by repeated dosing of acetaminophen or alcohol for 15 days. Expression analysis of fatty acid-binding protein 1 (FABP1), peroxisome proliferator-activated receptor-gamma (PPARγ), sterolregulatory element-binding protein 1 (SREBP1), nuclear factor-kappa β (NF-κβ) and tumor necrosis factor-alpha (TNF-α) genes from liver were assayed by a semi-quantitative polymerase chain reaction. Expressions of FABP1, PPARγ were downregulated while SREBP1, NF-κβ and TNF-α were upregulated in negative control. Treatment with Neem-giloe satwa upregulated the expression of FABP1 and down-regulated the expression of NF-κβ, SREBP1, TNF-α as compared to acetaminophen treated rats. Treatment with T. sinensis...
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