Posted by admin on Jun 30, 2020 in |
The present study involves the formulation and evaluation of floating in-situ gel containing piroxicam for the treatment of arthritis. In the FTIR and DSC study for compatibility of piroxicam with polymers, there are no significant changes observed so it is confirmed the absence of drug-polymer interactions. The gastric floating in-situ gel was prepared by using Sodium Alginate, HPMC K 200 M & other ingredients. The prepared situ gel of piroxicam was evaluated for pH, gelling capacity, floating lag time, total floating time, drug content, viscosity, in-vitro drug release. An optimization study was carried out by using was 32 factorial designs to find the effect of independent variables, i.e., amount of Sodium Alginate (X1) and HPMC K 200 M (X2) on dependent variables i.e., floating lag time & % CDR. The results showed that all the formulations exhibited a very short floating lag time. Most of the formulations floated within 1 min. All the formulations exhibited a basic pH in the range of 6.7 to 7.9 which is suitable for...
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Posted by admin on Jun 30, 2020 in |
Bacopa monnieri, Tinospora cordifolia, and Evolvulus alsinoides are conventional Ayurvedic floras that are useful in the various neuropharmacological ailment. This research focused on the effect of ethanolic extract of Bacopa monnieri (BME), Tinospora cordifolia (TCE), and Evolvulus alsinoides (EAE) were evaluated alone and in a combination of extracts (CEPs) by using scopolamine-induced oxidative stress in rats. Tissue homogenates were prepared, an indicator of Superoxide Dismutase (SOD), Glutathione (GSH), Lipid peroxidation (LPO), Catalase (CAT) and Acetylcholinesterase (AChE) enzyme activities were estimated in the rat brain. Due to scopolamine treatment, enhanced LPO and AChE level but reduced SOD, CAT, and GSH levels in rats brain were observed. Rats treated with BME, TCE, EAE, and their CEPs [CEP-1 (EAE and BME), CEP-2 (TCE and BME), CEP-3 (TCE and EAE) and CEP-4 (BME, TCE, and EAE)] at 200 mg/kg, provided significant effect against scopolamine because these extracts decreases LPO, AChE level and restored SOD, GSH, and Catalase levels in rats brain. The CEPs produced significant effects in comparison to BME, TCE, and EAE....
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Posted by admin on Jun 30, 2020 in |
Objectives: This work aimed to formulate and evaluate amikacin, fourth-generation fluoroquinolone antibiotic agent containing an in-situ gelling system based on sol-to-gel transition for ophthalmic delivery to overcome the problems of poor bioavailability and therapeutic response exhibited by conventional formulations based a sol-to-gel transition in the cul-de-sac upon instillation. Methods: In the present work, poloxamer 407 as a temperature-activated gelling agent and gelrite as an ion activated gelling agent were used in combination to prepared ion-sensitive and temperature-sensitive ophthalmic in-situ gel. The prepared formulations were evaluated for the parameters like pH, appearance, drug content, in-vitro gelation study, viscosity, in-vitro release study, sterility test, and stability studies. Results: In this study, the release profile depends on the concentration of gelrite and poloxamer 407. The selected formulation showed sustained release for a period of 10 h. Thus it showed increased residence and contact time with the eye. The draize test was performed with an optimized formulation for eye irritation test. It was found to be non-irritant to the rabbit eye. The in-situ...
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Posted by admin on Jun 30, 2020 in |
Parkinsonia aculeata (family – Caesalpiniaceae) is a large spinous shrub found in warmer regions of the world. It is a well known medicinal plant that has significant and promising biological activities such as antioxidant, anti-inflammatory, antidiabetic, antispermatogenic, etc. The phytochemical investigations of the leaves, flowers, and stem have revealed the presence of various glycosides, flavonoids, reducing sugars, alkaloids, sterols, tannins, volatile oils, and saponins. The various biological activities and potent phytoconstituents of the plant indicate its therapeutic potential efficacy. The present study shows the detailed investigation of the methanolic stem bark extract of the title plant. From the methanolic stem bark extract of the title plant 1-cyclohexyltridec-1-ene (new compound A), 6-hydroxypentacosylpentanoate (B), α-amyrin acetate (C), α-amyrin (D) and β-sitosterol (E) were isolated with the help of column chromatographic technique and characterized on the basis of different spectral studies i.e., 1H NMR, 13C NMR, IR, and Mass...
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Posted by admin on Jun 30, 2020 in |
Carvedilol is a non-selective β blocker with α1 blocking activity used in the treatment of congestive heart failure, high blood pressure, and left ventricular dysfunction. Following administration by the oral route, it undergoes extensive first-pass metabolism resulting in low bioavailability of 25-35%. The aim of the present study was to incorporate carvedilol in bilayered chitosan containing mucoadhesive buccal patches to ensure unidirectional drug release. Buccal administration circumvents hepatic first-pass metabolism, as the drug directly enters into the systemic circulation through the buccal mucosa, thereby increasing systemic bioavailability. The patches were prepared using solvent casting method. Chitosan was used as a mucoadhesive polymer as well as the base matrix for the drug. To improve film properties of the patches, PVP was incorporated in all the formulations. An impermeable backing layer of ethylcellulose was used to ensure the unidirectional release of the drug. The compatibility of carvedilol and polymers was confirmed by DSC and FTIR. Bilayered patches were evaluated for various physicochemical parameters like appearance, weight and thickness, folding endurance, tensile...
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