Posted by admin on Jul 31, 2020 in |
Current investigation was aimed at designing a Rosuvastatin calcium loaded drug- in- adhesive patch (DIAP) to overcome the problems associated with the daily oral administration of the drug. The patches were prepared by solvent casting method using acrylate emulsion polymers like Covinax 525-78, Mowinyl 461 and Novacryl PSR 32, which served as sustained release matrix polymer and adhesive. Methocel K100M was added as a solubilizer whereas propylene glycol (PG), labrasol, transcutol, and polyethylene glycol 400 (PEG400) were tried as permeation enhancers for the drug- in- adhesive film. The combination of Novacryl –PEG 400 and Novacryl-Transcutol was further optimized by 32 factorial design to study the effect of two independent variables i.e. concentration of solubilizer and permeation enhancer on responses i.e. % drug release, tensile strength and peel adhesion strength. The effect of the solubilizer and permeation enhancer on the final formulation was studied. The % cumulative release of drug at the end of 24 h was found to be between 90-93%. The formulations also show tensile strength in the...
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Posted by admin on Jul 31, 2020 in |
In the present work, the aim was to prepare a self-emulsifying drug delivery system of poorly soluble analgesic, mefenamic acid to improve its solubility with a view to enhance its oral bioavailability. From the solubility studies the selected oil, surfactant and co-surfactant was soyabean oil; tween 80, span 20; glycerol. Blends of surfactant mixtures containing tween 80, span 20, and glycerol were prepared. Three ratios of Smix containing tween 80: span 20: glycerol viz. 1:0.25:1, 1:1:1, 2:2:1; were used to construct pseudo ternary phase diagram to select nine formulation composition. Nine self-emulsifying formulations of mefenamic were prepared and evaluated for optical transparency, low refractive index, uniformity index, low viscosity, and drug release. The best formulations in all aspects of the evaluation were subjected to stability testing. The optimized formulation has been found to have good physical stability and longest shelf life of 13.45 months under accelerated storage conditions with degradation rate constant 1.38 × 10-3...
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Posted by admin on Jul 31, 2020 in |
Dorzolamide is commonly used to treat glaucoma, damage in the eye often caused by abnormally high pressure in the eye. It is one of the carbonic anhydrase inhibitors which is effective in decreasing intraocular pressure by decreasing the production of the aqueous humor. The main objective of the study was to entrap dorzolamide in a novel nanovesicular carrier system (spanlastics) to ensure sustained and intravitreal delivery in eye to overcome the problem of frequent dosing. The Dorzolamide spanlastics prepared were checked on three factors, i.e., the ratio of Span 60: Tween 80, sonication time and stirring speed. The formulation was evaluated for various parameters such as the size of nano-vesicles, Polydispersity index, zeta potential, and entrapment efficiency. The mechanism involved destabilization of lipid bilayer of the cell, which in turn facilitates diffusion of a drug within the cell and increased bio-availability. Hence, Dorzolamide spanlastics may prove to be an effective formulation in...
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Posted by admin on Jul 31, 2020 in |
In Asian countries, roots, barks, stems, leaves, and fruits of plants belonging to the Morinda species are considered as valuable traditional herbs. They are used in folk medicine for the treatment of many diseases, including diabetes, high blood pressure, and cancer. Anti-tubercular and cytotoxic activities of Morinda citrifolia (noni) have been reported, but Morinda coreia has not been explored for these two activities to date. In the present study, a systematic investigation was carried out with the air-dried leaves of M. coreia by bio-assay guided fractionation by three different extraction methods including conventional solvent extraction (SE), microwave-assisted extraction (MAE) and ultrasound-assisted extraction (UAE) methods to identify the best method for extraction for bioactive fractions responsible for anti-mycobacterium and anticancer activities. The n-hexane fraction of M. coreia was found to be most with MIC values ranging from 125 µg/L for SE and to 62.5 µg/mL for UAE against Mycobacterium H37Rv. Similar results were obtained against MCF-7 cells with IC50 values 33.78 µg/mL for SE and 22.22 µg/mL for UAE. In...
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Posted by admin on Jul 31, 2020 in |
Seeds of Macrotyloma uniflorum Linn. (Fabaceae) are widely used for treatment in kidney stones in India. In This study evaluates the in-vitro effect of methanolic extract of Macrotyloma uniflorum (MEMU) on calcium oxalate crystallization. A methanolic extract of M. uniflorum seeds at different concentrations (250-1500 μg/ml) was subjected to in-vitro crystallization activity. The obtained results were compared with a Cystone (standard herbal product) available in the market. The nucleation and crystal growth assay was performed with different concentrations of sodium oxalate (2-10 mmol/ml for nucleation, 2-3.5 mmol/ml for crystal growth) and evaluated the effect of MEMU and cystone at different doses (250-1500 μg/ml) on the different concentration level of oxalate. Crystal aggregation and crystal dissolution assay were performed and compared with cystone effect. The MEMU was significantly more effective than cystone at inhibiting the nucleation rate and crystal growth at a different concentration level of oxalate. Inhibition of calcium oxalate crystal aggregation and dissolution was observed in a dose-dependent manner. The results showed that MEMU has excellent in-vitro calcium...
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