Posted by admin on Aug 31, 2020 in |
The nasal drug delivery system has been a promising route for delivery of proteins and peptides as it can avoid degradation in the gastrointestinal tract and metabolism by liver enzymes. However, due to the rapid mucociliary clearance, the bioavailability of proteins and peptides is still low. Hence, mucoadhesive microspheres may prolong the residence time of peptide drugs in nasal cavity and improve their absorption. In the present study chitosan microspheres loaded with a model peptide vancomycin hydrochloride were prepared. Drug-excipient compatibility studies were done to investigate and predict any possible interactions between the components in the formulation. The prime objective of the study was to check the influence of different process variables and formulation parameters on the two key parameters viz particle size and percentage entrapment efficiency of vancomycin loaded chitosan microspheres and to develop a formulation with desirable particle size for nasal delivery and with maximum possible entrapment efficiency. Drug-excipient compatibility study indicates that vancomycin hydrochloride is compatible with the polymer chitosan. Drug loaded chitosan microspheres were successfully...
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Posted by admin on Aug 31, 2020 in |
The present research was envisaged on the development of dry powder to treat asthma. Terbutaline sulphate (a bronchodilator) and Itraconazole (an antifungal) were used in the present study for bronchodilation and allergy to Aspergillus fumigatus (fungi) using lactose and trehalose as excipients. Dry powder insufflations were prepared by physical mixing (milling) and spray drying, out of which spray dried formulations with lactose as excipient gave the best results in-vitro. Hence, spray dried formulations were preceded for further pharmacokinetic and stability studies. The pulmonary concentrations of Terbutaline sulphate and Itraconazole from TER – A (sd), ITR – A (sd), TER: ITR – A (sd) monotonically decreased (Tmax = 0 min). However, Itraconazole showed higher AUC0-α in individual and combined formulation when compared to Terbutaline sulphate showing slower elimination of Itraconazole. From plasma pharmacokinetic data Tmax of Itraconazole formulations ITR – A (sd), TER: ITR – A (sd) was high when compared to the formulations of Terbutaline sulphate TER – A (sd), TER: ITR – A (sd) showing lower systemic bioavailability...
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Posted by admin on Aug 31, 2020 in |
Background: Cardiovascular disease (CVD) is the leading cause of death worldwide. Management of behavioral risk factors is recommended for primary and secondary prevention of CVDs. There is evidence that the involvement of community pharmacies in health promotion activities is successful. Objectives: This study was conducted to assess community pharmacists’ perception and current practice in providing lifestyle assistance to patients with cardiovascular disease and to identify potential barriers to the provision of lifestyle assistance in Klang Valley, Malaysia. Method: A cross-sectional study was conducted among community pharmacists in Klang Valley using convenience sampling. A self-administered 54-item questionnaire was used to collect information on the current practice and perception of community pharmacists, and potential barriers in providing lifestyle assistance to patients with cardiovascular disease. Results: The response rate was 62.8%. Most of the services investigated were available in the pharmacy except for advice on alcohol consumption (52.7%) and screening and/or monitoring services for obesity (57.7%), which are less likely to be available. For most of the listed activities in relation to...
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Posted by admin on Aug 31, 2020 in |
Rumex obtusifolius, belonging to the Polygonaceae family, commonly known as ‘broad-leaf-dock’ is one of the most important medicinal plants. It is common wayside weeds and uses as an antidote to nettle, depurative, astringent, laxative, and tonic and in the treatment of sores, blisters, jaundice, burns, cancer, and tumors. In this study, we design to synthesize silver nanoparticles from silver nitrate via a green route using the aqueous leaf extracts of Rumex obtusifolius. This biogenic reduction of metal ion to base metal is quite rapid, readily conducted at room temperature and pressure, and easily scaled up. The use of silver nanoparticles is gaining popularity due to its antibacterial properties. The silver nanoparticles formation in the solution was monitored by UV-Vis spectroscopy, and further characterization was carried out by FT-IR (Fourier Transform Infrared Spectroscopy), XRD (X-ray Diffraction), SEM (Scanning Electron Microscopy) and TEM (Transmission Electron Microscopy) analysis. To optimize the biosynthesis of silver nanoparticles, the effect of process variables such as extract concentrations, the mixing ratio of the reactants, time, and...
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Posted by admin on Aug 31, 2020 in |
The aim is to prepare sustained release multi-particulates dosage form of Dexketoprofen trometamol, which is the active isomer of ketoprofen. Utilization of active moiety with minimum drug dose and administration frequency sustained-release multi-particulates dosage form is explored. Sustained release pellets of the dexketoprofen trometamol were developed by the fluidized bed technology, in which drugs along with a binder and anti-adherent agents, were loaded onto microcrystalline cellulose inert beads. These drug-loaded pellets were again coated with Kollicoat SR 30D as sustained-release coating polymer, triethyl citrate as plasticizer and talc as an anti-adherent. The formulation was further statistically optimized for agglomerates formation, process efficiency, and drug release profile using central composite design (CCD). Results show that 16.9 to 18.5% w/w sustained release coating with 9.0-14.6% w/w talc and 8.1 to 16.5% w/w triethyl citrate concentration gives desired drug product quality attributes. Sustained-release multi-particulates were successfully developed for dexketoprofen trometamol, which maybe explored to manufacture various dosage forms like capsules, compressed tablets, pellets in sachet etc. for ease of patient...
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