Posted by admin on May 31, 2020 in |
Verapamil hydrochloride is a water-soluble drug, so it is suitable to develop controlled porosity osmotic pump. As Verapamil HCl is a short-acting drug, so developed formulation provides the advantages of controlled release formulations. The developed formulation provides advantages of less steps of manufacturing procedure, no need for laser drilling, and economical, all of which made the procedure easily amenable to mass production using conventional tablet machines. Verapamil HCl 120 mg core formulations were prepared coated with film former (cellulose acetate): pore former (sorbitol). The effect of different formulation variables, namely, membrane weight gain, and amount of pore former in the membrane, were studied. Verapamil HCl release was inversely proportional to the membrane weight (coating thickness) but directly related to the initial amount of pore former (sorbitol) in the membrane. Drug release from the developed formulations was independent of pH but dependent on the osmotic pressure of the release medium. Verapamil HCl release from the developed formulation follows zero-order. The drug release from formulation was proved as dependent on osmotic...
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Posted by admin on May 31, 2020 in |
A glycyrrhetinic acid isolated from herbal plant Glycyrrhiza glabra (family Fabaceae), commonly known as licorice is used to formulate microemulsion as a self-emulsifying drug delivery system for oral administration using almond oil as the oil phase. Pseudoternary phase diagrams were constructed to determine the microemulsion existence region using surfactant (Tween 80) and co-surfactant (propylene glycol). Different formulations in the form of microemulsions were prepared to evaluate the effect of oil content, surfactant/co-surfactant concentration on in-vitro diffusion rates. In-vitro drug diffusion of glycyrrhetinic acid from the microemulsions was evaluated using the dialysis membrane. The amount of glycyrrhetinic acid permeated was analyzed by using the UV method. The permeability of the glycyrrhetinic acid incorporated into the microemulsion systems was considerably increased than that of the plain drug. These results indicate that the microemulsion system studied is a promising tool for increasing the solubility and oral absorption of glycyrrhetinic...
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Posted by admin on May 31, 2020 in |
The present research work was envisaged to develop immediate release film-coated tablets of a fixed-dose combination of Atorvastatin calcium and Amlodipine besylate used to treat the hyperlipidemia, angina pectoris, atherosclerosis, hypertension and symptoms of cardiac risk. Additionally, fixed-dose combination therapy of both drugs tends to provide a synergetic effect and reduce the pill burden. Immediate-release tablets are mostly recommended for fast upgrading drug delivery systems, and thus, an effort was made to improve the onset of action of the drug. The concept of formulating immediate-release tablets using superdisintegrants like CCS offers a suitable and practical approach to faster disintegration and dissolution characteristics. In the current investigation two methods were adopted namely direct compression and wet granulation for formulation development. Based on the drug content and dissolution results, the direct compression method was used for further study. The prepared dosage forms were also subjected to pre and post compression evaluations. The results of in-vitro drug release suggested that CF6 was the ideal formulation among all the other formulations. In-vitro drug...
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Posted by admin on May 31, 2020 in |
The aim of the present work is to determine the feasibility of peracetic acid (PAA) and the coexistent hydrogen peroxide (HP) simultaneous quantitative determination in disinfectant solution by voltammetry using carbositall rotation electrode (CE) as indicating electrode. It has been experimentally proved that the optimum pH for analysis is approximately 3.6. The linear relationship has been observed in the PAA concentration range (3.12–12.50)´10–5 mol L–1, the calibration curve equation was Iр = (3.78 ± 0.46)´103с (r = 0.995); in the HP concentration range of (0.94–3.76)´10–4 mol L–1, the calibration curve equation was Iр = (3.57 ± 0.26)´103с + (0.11 ± 0.07) (r = 0.998). Determining PAA in the working solution with the concentrations of 6.24´10–5, 7.80´10–5 and 9.36´10–5 mol L–1 the RSDs were 0.035, 0.028 and 0.022 respectively (δ = +0.30…+0.90%), determining HP in the working solution with the concentrations of 1.88´10–4, 2.35´10–4 and 2.82´10–4 mol L–1 the RSDs were 0.028, 0.018 and 0.011 respectively (δ = –0.77…+0.92%). Determining PAA in the test solution of “Delakson” disinfectant with the concentrations of 0.1%, the RSD...
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Posted by admin on May 31, 2020 in |
Present work was aimed to determine, identify, and characterize the bioactive chemical compounds from methanolic leaves extract of Abutilon fruticosum by GC-MS analysis. Fresh disease-free leaves were collected shade dried and powdered for extraction with HPLC grade methanol. Preliminary phytochemical screening of methanolic leaves extract was performed using standard methods to determine the presence of different chemical compounds; the crude extract was subjected to GC- MS analysis for the identification of bioactive compounds. Phytochemical screening of methanolic leaves extracts revealed the presence of carbohydrates, proteins, alkaloids, phenols, flavonoids, terpenes, phytosterols, etc. Furthermore, GC MS analysis of the extract revealed the presence of 65 bioactive compounds. Some major biologically active compounds identified were Azulene (24.91%), Hexadecanoic acid (13.27%), Phytol (9.51%), Beta-sitosterol (3.19%), Lupeol (1.21%), Campesterol (0.33%) etc. These chemical compounds are biologically active and pharmacologically important. The study provides detailed information about the identification and chemical characterization of various medicinally important phytocompounds from methanolic leaves extract of this plant. Although the plant is rare and endemic to Indian Thar Desert...
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