Posted by admin on May 31, 2020 in |
Even though numerous herbal preparations have been recommended in alternative systems of medicine against hepatic disorders, many of them cause severe toxicity upon prolonged use. Volvariella volvacea (Bull.: Fr.) Singer is a highly nutritious mushroom that can be incorporated into the regular diet without the fear of side effects. The protective effect of the aqueous ethanol extract of V. volvacea mycelia was evaluated against acetaminophen (APAP) induced hepatic damage in Wistar rats. A single dose of APAP (3 g/kg, p.o.) was used for inducing hepatic damage. The extract was administrated orally at doses of 250 and 500 mg/kg, once daily for 7 days. Treatment with APAP (3 g/kg) increased the activities of liver function enzymes serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP). APAP also reduced the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and enhanced lipid peroxidation in liver tissue. Administration of V. volvacea extract (500 mg/kg, p.o.) decreased the activities of SGPT, SGOT, and ALP. It also...
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Posted by admin on May 31, 2020 in |
The objectives were to observe the drug pattern of epileptic patients with their seizure type, to analyze the type of therapy received by the patients, to observe if epileptic patients are receiving an appropriate dose, to identify the side effects in epileptic patients associated with drug treatment and to observe the cost of conventional and newer antiepileptic drugs (AED’s). This was a cross-sectional observational study conducted in the Neurology department. A total of 150 patients were selected based on the inclusion and exclusion criteria. Demographic details and clinically relevant details such as therapy, dose of the drug, side effects experienced pertaining to the objectives of the study were collected using the self-prepared proforma. Symptomatic localization (64%) was the most commonly observed epilepsy syndrome. The commonly observed type of therapy among the patients was dual therapy. AED dose prescribed for most of the adult population was at a sub-optimal level, as explained by the daily defined dose/ prescribed daily dose (DDD/PDD) ratio (<1). Carbamazepine and oxcarbazepine were prescribed at a...
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Posted by admin on May 31, 2020 in |
Schiff bases from chitosan and 5-nitro salicylaldehyde-aniline complexes represented the important structural subject in excess of biologically active molecules, including synthetic. The introduction of 5-nitro salicylaldehyde at C-2 nitrogen position and aniline at C-6 oxygen position of chitosan. The structure-activity relationship (SAR) of the double Schiff based chitosan, synthesized from the condensation reaction of equimolar amounts of 5-nitrosalicyl-aldehyde, chitosan, and aniline in DMSO. The chitin and the phenyl rings deviate from co-planarity with an inter and intra-molecular bond (–C2-N=CH–), (–C6–C=N–). The title compound C69H118N11O43 is not a planner, with a dihedral angle among the planes of the three aryl rings. The structure is a heterocyclic derivative constituting a stimulating class of compounds with synthetic flexibility and productive biological activities. The synthesized compound structurally categorized by FT-IR, 1H-NMR, GC-Mass spectra, and TG/DTA studies. The 1H-NMR spectroscopy used to determine the degree of acetylation in chitosan. The synthesized compound primarily parted for their in-vitro growth constraining activity against a different strain of bacterial and fungal. The in-vitro antioxidant activity of the...
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Posted by admin on May 31, 2020 in |
Moringa is one of the medicinally important genera and Moringa concanensis Nimmo is a threatened species of it. Clonal micropropagation has been used to produce true to type multiple copies and help to conserve a number of plants. A comprehensive micro-propagation protocol has been developed in the present study. It was found that Murashige and Skoog (1962) (MS) basal elements enriched with 0.05 mg/L of 1-naphthalene acetic acid (NAA) in combination with 0.3 mg/L of 6-benzyl amino purine (BAP) induced 93.3% shooting and maximum (5.5 ± 1.63) number of micro-shoots. Shoot elongation and multiplication were recorded to enhance by making use of 1.0 mg/L of Gibberellic acid (GA3). Maximum rooting (83.3%) was observed on half-strength MS basal media supplemented with 0.5 mg/L of Indole 3-Butyric Acid (IBA) in combination with 0.5 mg/L NAA. Even though the success of this protocol is varied according to genotype, it still has high applicability for the conservation of germplasm of...
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Posted by admin on May 31, 2020 in |
Objective: Senecio vulgaris Linn. generally known as common groundsel, known in Iraq as Sheikh Al-Rabeeor Al-Kurresa, which is widely distributed in the south and middle parts of Iraq. There was no systemic study in the literature regarding the phytoconstituents that are present in Iraqi’s Senecio vulgaris Linn. Thus, the present study was aimed to examine the presence of some biologically important secondary metabolites that are present in this plant as well as investigate the essential oil components and their percentage presenting it. Method: The steroid rich fraction was subjected to analytical thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC) analysis in order to identify the presence of steroidal compounds, after authentication and by comparison of these steroids with their standards. Also, the essential oil obtained from this plant by Clevenger apparatus was analyzed using gas chromatography-mass spectrometry (GC-MS) to determine the types and quantities of the monoterpenoids, diterpenoids, and triterpenoids present. Results: The qualitative analysis performed by TLC and HPLC revealed the presence of biologically active secondary metabolites such...
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