Posted by admin on May 31, 2020 in |
Antioxidants are the substance having the potential to quench free radicals and significantly delay or inhibit oxidation of the substrate, thus protect biological systems against potentially harmful effects of free radicals; in low concentrations. The present study was aimed to evaluate the in-vitro antioxidant activity of Oldenlandia corymbosa L., a locally available medicinal plant of Assam, used as vegetable in diet and traditional medicine for liver disease and jaundice. The dried powdered plant material was extracted with 80% ethanol by Soxhlet extraction and was used for the fractionation in different solvents (methanol, petroleum ether, and ethyl acetate). The fractionated extracts were subjected to the analysis of in-vitro antioxidant activity with DPPH (2,2, Diphenyl-2-picryl hydrazyl), hydroxyl radical, nitric oxide, reducing power, and phosphomolybdenum assays for total antioxidant capacity. Ascorbic acid was used as standard at concentrations (20 μg/ml, 40 μg/ml, 60 μg/ml, 80 μg/ml and 100 μg/ml) dissolved in ethanol. Samples were prepared in the same manner. Results from in-vitro experiments revealed the significantly (p<0.05) high antioxidant activity in hydro-ethanolic...
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Posted by admin on May 31, 2020 in |
Background: Lafutidine floating beads as a gastro-retentive dosage form antagonisms of histamine H2 receptor. It is used as anti-ulcerative agent. It is effective against the oesophageal lesions induced by acid reflux through inhibition of acid secretions. Objectives: The objective of the present work was to formulate and evaluate the floating beads of Lafutidine as a model drug. The objective of this study is to develop a simple uncomplicated and easy to manufacture floating beads that are capable of delivering lafutidine at a prolonged release rate of delivery. It has a short half-life (3 h). It has a low bioavailability (60-80%). The frequent dosing, which results in unacceptable patient compliance. Methods: Lafutidine was received as a gift sample and a thorough pre-formulation study was performed on a given sample in order to estimate the physicochemical properties like solubility, melting point, partition coefficient to confirm the authenticity of sample and to confirm that there are no significant barriers to the development of dosage forms. 12 different formulation of lafutidine floating alginate...
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Posted by admin on May 31, 2020 in |
The objective of the method is to develop a rapid, simple, accurate, precise RP-HPLC method for the simultaneous estimation of Ivabradine and Metoprolol in tablet dosage form. The analytes were run through BDS C18 150 × 46 mm, 5µm column, and detected at a wavelength of 260 nm using PDA 996 (photodiode array) detector. Mobile phase containing buffer 0.01N disodium hydrogen phosphate (3.5±1 pH) and acetonitrile in the ratio of 65:35 v/v was pumped through the column at a flow rate of 1.0ml/min and run time is about 6 min. The temperature was maintained at 30 °C. Retention times of ivabradine and metoprolol were found to be 2.38 min and 3.53 min. Percentage RSD of ivabradine and metoprolol was found to be 0.4 and 0.7, respectively. Percentage recovery of ivabradine and metoprolol were found to be 99.80% and 100.11%. LOD and LOQ values obtained from regression equations of ivabradine and metoprolol were found to be 0.03, 0.08, and 0.26, 0.79, respectively. The degradation studies were performed by applying different...
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Posted by admin on May 31, 2020 in |
Introduction: an Inflammatory bowel disease is a group of chronic intestinal diseases characterized by inflammation of the bowel, the large or small intestine. The common types of inflammatory bowel disease (IBD) are ulcerative colitis UC and Cohn’s disease CD. Among the Asian countries, India is subjected to have one of the highest disease burdens of IBD across the globe. The number of IBD cases exceeds 12 lakhs annually, and an estimated 50 lakhs people are affected with IBD around the world stated by Indian statistics. Objective: To assess the quality of life in patients with inflammatory bowel disease and to associate with the sociodemographic characteristics of the patients. Materials and Methods: This was a prospective observational study carried out with 74 patients, and follow-up was conducted for 6 months at the outpatient clinic of Gastroenterology. A specially designed data collection form was utilized to collect patient’s demographic details and validated questionnaires to measure the quality of life. Results: Among 74 patients evaluated, there were an equal number of males...
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Posted by admin on May 31, 2020 in |
In the present research, the pharmacokinetic Drug-drug interactions between HMG-COA reductase inhibitors Pitavastatin with concomitantly used Ticagrelor have been studied. Pitavastatin is a member of the blood cholesterol lowering medication class of statins while Ticagrelor is a platelet aggregation inhibitor. Combination therapy with statins and other cardiovascular medications is recommended for patients at high atherosclerotic cardiovascular patient’s risk. The effect of Pitavastatin on the pharmacokinetics of Ticagrelor was studied on male Wistar rats divided into four different groups, I group is control group, II group of healthy rats administrated with Pitavastatin only in single-dose per day. III group of healthy rats administrated with Ticagrelor in a single dose per day and IV Group of healthy rats administrated with Pitavastatin and Ticagrelor in a single dose per day. The result evaluated by student’s paired T-Test and the results indicate no significant increase in peak plasma concentration of Pitavastatin (7.12 ± 2.12 ng/ml) and Ticagrelor (80.02 ± 3.03 ng/ml) when administrated alone or in combination (7.32 ± 1.12 ng/ml and 82.83...
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