Posted by admin on Apr 30, 2020 in |
Diltiazem HCl is a calcium ion channel inhibitor. The capacity to hinder the convergence of calcium ion present in of cardiac and vascular smooth muscle during membrane depolarization is accepted to be its therapeutic impact. It is broadly utilized in the treatment of a few kinds of cardiovascular disorders. For accomplishing better drug viability, unwavering quality success within the leading edge pharmaceutical structure, and targeted analysis, sustained-release drug delivery has touched toward changing into gauges. The biggest offer of drug delivery frameworks, for example, up to 80% of all the medication records to the OSRDD (Oral Sustained Release Drug Delivery). Sustained releases tablets of diltiazem HCl was planned to utilize Hydroxypropyl methylcellulose (HPMC 643), and povidone in various ratios, the extended-release conduct of fabricated tablets were then assessed. Sustained-release diltiazem HCl tablets were made by the direct compression method. The formulation was streamlined based on various tablet properties and drug release design in-vitro release profile. The subsequent formulation created tablets with required hardness, weight uniformity, and friability. The aftereffect...
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Posted by admin on Apr 30, 2020 in |
The phytochemical analysis of ethanol extract of Scurrula parasitica showed positive results for alkaloid, saponins, tannin, terpenoids, flavonoids, phenol, reducing sugar and phytosterols whereas glycoside is found to be absent. Total phenol and flavonoid contents were evaluated and found to be total phenolic compounds (101.9-379.1 µg/g tissue) and total flavonoids (72-174.1 µg/g tissue), respectively. The free radical scavenging activity of ethanol extracts of Scurrula parasitica (Loranthaceae) was determined to validate the medicinal potential of the plants. The antioxidant activity was performed by 2, 2-Diphenyl-1-picrylhydrazyl (DPPH) assay and ABTS + cation. The optimum concentration for both DPPH and ABTS was obtained at 100 µg/ml with an IC value of 53.28100 µg/ml and 160.8100 µg/ml, respectively. Therefore, the high content of both phenols and flavonoids might contribute to the anti-oxidative...
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Posted by admin on Apr 30, 2020 in |
Various nitrogenous heterocyclic compounds like 1, 8-naphthyridine-3-carboxamide are synthesized and studied for their wide range of biological activity. Versatile activity of this scaffold will increase interest from innovator on significance of their antibacterial activity and will influence their role in drug discovery. Synthesis and Antibacterial evaluation of ten derivatives of 1-ethyl-4-oxo-1, 4-dihydro-1, 8-naphthyridine-3-carboxamide (SD-1 – SD-10) is discussed in this paper. Synthesis of novel 1, 8-naphthyridine-3-carboxamide derivatives starting from substituted pyridine with ethoxy-methylenemalonate ester by cyclo-condensation reaction affords 1,8-Napthyridine-3-carboxylate at high temperature and at specific reaction condition. All 1, 8-napthyridine-3-carboxylate compounds were treated with an excess of substituted aniline with mild reaction conditions. All the compounds obtained were purified by using the recrystallization method. Structure confirmation of synthesized compounds was accomplished on the basis of IR, 1H NMR, and MS. The synthesized compounds were tested against bacterial strain, Escherichia coli (Gram-negative) Staphylococcus aureus (Gram-positive). Many of the compounds exhibited significant antibacterial...
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Posted by admin on Apr 30, 2020 in |
Ushirasava is a commonly used ayurvedic formulation reported to be effective in Raktapitta (Bleeding disorders), Pandu (Anaemia), Kustha (Skin diseases), Prameha (Urinary disorders), Arsa (piles), Krmi (Worm infestation) and Sotha (Inflammatory diseases). It is a polyherbal hydroalcoholic product comprising of more than twenty-five ingredients. An exhaustive literature survey revealed that standardization of Ushirasava is not reported to date. The research work described here aims to standardize some marketed formulations of Ushirasava with respect to their physicochemical (Organoleptic properties, phytochemical, and microbial parameters. It also aims to develop and validate a new HPTLC method for the quantitative estimation of luteoin and rubiadin present in the test formulations of Ushirasava. The standardization of Ushirasava involved a determination of organoleptic and physicochemical properties, phytochemical screening, identification and quantitative analysis of some bioactive constituents by HPTLC. The ‘protocol for testing Ayurveda, Siddha, and Unani medicines’ was used as a reference. Luteolin and rubiadin were selected as the chemical markers for quantitative analysis. An HPTLC method was developed and validated as per the International...
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Posted by admin on Apr 30, 2020 in |
Sialic acid is the active site of neuraminidase virus and it proliferates the infection in the human body by cleaving it from the neuraminidase viral protein. The buried water molecule influences the binding between the ligand and the receptor. Hence, solvation dynamics and hydration pattern of sialic acid needs to be investigated to design the antiviral inhibitor. Cluster continuum solvation analysis reveals that the hydrated structures of sialyate ion are progressive increases as a function of water molecules by explicit solvation method, and this pattern attests the presence of buried water molecules in the hexa hydrated structure. Thus, it confirms the presence of trapped water molecules near the functional site of sialic acid. Hence, it can be considered as a promising candidate for the design of a sialidase antiviral...
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