Posted by admin on May 31, 2020 in |
Moringa is one of the medicinally important genera and Moringa concanensis Nimmo is a threatened species of it. Clonal micropropagation has been used to produce true to type multiple copies and help to conserve a number of plants. A comprehensive micro-propagation protocol has been developed in the present study. It was found that Murashige and Skoog (1962) (MS) basal elements enriched with 0.05 mg/L of 1-naphthalene acetic acid (NAA) in combination with 0.3 mg/L of 6-benzyl amino purine (BAP) induced 93.3% shooting and maximum (5.5 ± 1.63) number of micro-shoots. Shoot elongation and multiplication were recorded to enhance by making use of 1.0 mg/L of Gibberellic acid (GA3). Maximum rooting (83.3%) was observed on half-strength MS basal media supplemented with 0.5 mg/L of Indole 3-Butyric Acid (IBA) in combination with 0.5 mg/L NAA. Even though the success of this protocol is varied according to genotype, it still has high applicability for the conservation of germplasm of...
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Posted by admin on May 31, 2020 in |
Objective: Senecio vulgaris Linn. generally known as common groundsel, known in Iraq as Sheikh Al-Rabeeor Al-Kurresa, which is widely distributed in the south and middle parts of Iraq. There was no systemic study in the literature regarding the phytoconstituents that are present in Iraqi’s Senecio vulgaris Linn. Thus, the present study was aimed to examine the presence of some biologically important secondary metabolites that are present in this plant as well as investigate the essential oil components and their percentage presenting it. Method: The steroid rich fraction was subjected to analytical thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC) analysis in order to identify the presence of steroidal compounds, after authentication and by comparison of these steroids with their standards. Also, the essential oil obtained from this plant by Clevenger apparatus was analyzed using gas chromatography-mass spectrometry (GC-MS) to determine the types and quantities of the monoterpenoids, diterpenoids, and triterpenoids present. Results: The qualitative analysis performed by TLC and HPLC revealed the presence of biologically active secondary metabolites such...
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Posted by admin on May 31, 2020 in |
Background: Vitamin D deficiency and its associated disorders are prevalent in Saudi Arabia. This study aimed to assess the awareness levels towards vitamin D, check, medication, and related disorders. Methodology: In this cross-sectional study, a total of 500 Saudi volunteers living in the city of Hail (A region in Northern Saudi Arabia) and surrounding towns were included during the period from January 2020 to March 2020. Results: Out of the 500 participants, 295/500(59%) were found to complain from one or more VDD related conditions. Out of the 500 participants, only 214/500 (42.8%) experienced previous vitamin D testing. According to vitamin D testing results, 107/214 (50%) and 53/214 (24.8%) of the individuals did the test was found with vitamin D deficiency and vitamin D insufficiency, respectively. Conclusion: VDD is prevalent in Hail Region, Saudi Arabia, particularly among females. The scarcity of routine testing for vitamin D status resulted in multifarious VDD related disorders. Hail’s population has a low awareness of vitamin D check, medication and related...
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Posted by admin on May 31, 2020 in |
Dabigatran Etexilate Mesylate (DEM), an anticoagulant used to treat and prevent blood clots and to inhibit the occurrence of stroke in people with cardiac arrhythmia. The purpose of this study was to obtain DEM co-crystals by screening eight different conformers and prepare the co-crystals by evaporation technique. Molecular docking was used to identify suitable coformer. Tartaric acid DEM co-crystals have been effectively prepared in the molar ratio of 1:1, 1:2, and 1:3 by solution-based evaporation technique. A 1:1 molar mixture of DEM and tartaric acid was further characterized. Differential scanning calorimetry, Fourier Transform Infrared Spectroscopy (FTIR), Powder X-ray Diffraction (PXRD) and Scanning Electron Microscopy (SEM) were used to characterize manufactured co-crystals. The study confirmed the selection of proper coformer and exhibited enhanced solubility and stability of the DEM co-crystals. Hence, based upon the above results, it revealed that co-crystallization helps in improving the physicochemical properties of the API, altering their chemical...
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Posted by admin on May 31, 2020 in |
Background: The aim of this prospective study was to observe the efficacy of Trimetazidine (TMZ) and Isosorbide dinitrate (ISDN) in Coronary Artery Disease (CAD). Through inhibition of cardiac fatty acid oxidation, trimetazidine strengthens the treatment of CAD, by relieving aggravation; enhancing heart function, essential to prevent heart failure and other serious complications. Methods: 120 patients with CAD were selected as research subjects and randomly divided into two groups as observational (Group O) and control (Group C), with 60 patients in each group. The control group was on the conventional treatment of CAD whereas the observational group was using TMZ and ISDN along with the conventional treatment. The blood pressure, C-reactive protein (CRP), left ventricular ejection fraction (LVEF), troponin T and ST-segment levels of two groups were measured and compared at the baseline and after 2nd & 4th month respectively. Results: This study analyzed, compared to the baseline (P>0.05) the BP, CRP, troponin T and ST-segment levels after 2nd and 4th month were significantly decreased while LVEF increased significantly in...
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