Posted by admin on Mar 31, 2020 in |
Introduction: The aim of the present study is to formulate and evaluate the simvastatin chronopharmaceutical delivery system using a novel coating method to mimic the circadian rhythm of the disease by releasing the drug with a distinct predetermined lag time of 6 h. Observation: Simvastatin is a hyperlipidemia drug that inhibit the synthesis of cholesterol by inhibiting the HMG-COA reductase enzyme. Experiment: The basic design of the system consists of a rapid release core and a controlled release coat. The powder blend was evaluated for the angle of repose, Carr’s index, Hausner ratio, and compressibility index. The core tablet was evaluated for in-vitro release. The coated tablet was evaluated for weight variation, hardness, thickness, friability, disintegration, in-vitro dissolution, in-vitro comparative study, acid uptake test, rupture test, swelling studies, SEM, stability studies and FTIR, etc. Results and Discussion: The preformulation studies were revealed compatible results, and the rupture time, swelling time, acid uptake study showed satisfactory results by which it indicates the core molecule will be released at a prominent...
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Posted by admin on Mar 31, 2020 in |
Carissa spinarum is an evergreen, thorny shrub found in the Himalayan areas of the Indo-Pakistan subcontinent. The plant has a number of ethnomedicinal applications. Pharmacologically this plant is used for the treatment of asthma and pulmonary diseases, anticancer, diarrhea, hepatoprotective, cardioprotective and reproductive dysfunction. The present study is aimed to study effects of Carissa spinarum methanolic leaf extract in alloxan treated mice liver and kidney tissues. First group mice served as control and were given distilled water only. Second group mice were given Carissa leaf extract orally to a dose of 800 mg/kg body weight. Mice were injected with intraperitoneal injection of alloxan monohydrate at a dose of 120 mg/kg body weight and were further divided into three groups. Third group mice served as diabetic control and were given distilled water. Fourth and fifth group diabetic control mice were given Carissa leaf extract orally to a dose of 600 and 800 mg/kg bodyweight for 28 days. Sixth group mice were given glimepiride at a dose of 2mg/kg body weight....
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Posted by admin on Mar 31, 2020 in |
Objective: The present study is considered to estimate preliminary phytochemical components, physicochemical parameters, HPTLC chromatographic studies and antidepressant activity of chlorogenic acid & gallic acid present in extracts of Morus alba leaves. Methods: Total phenol content, total flavonoid content, total tannin content, HPTLC fingerprinting analysis for compounds like chlorogenic acid & gallic acid responsible for antioxidant activity and antidepressant activity by TST & FST. Result: Preliminary phytochemical studies shows the presence of good phenol (21.75 ± 1.21) and flavonoid (14.83 ± 2.34) content. HPTLC fingerprinting by comparing extract values with standards available of chlorogenic acid and gallic acid also shows the presence of these components in the methanolic and ethanolic extracts of Morus alba leaves, which were further used to screen antidepressant activity and shows substantial antidepressant activity in the plant. Conclusion: Our results recommend that Morus alba leaves are may be demonstrated to be an acceptable natural antioxidant and antidepressant with various bioactive components used for the treatment of numerous other...
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Posted by admin on Mar 31, 2020 in |
Simple RS method is developed and validated as reversed-phase chromatographic method for the identification and quantification of the dipyridamole related substances-A, B, C, D, E and F. Chromatographic separation has been achieved by using Shodex C18, 150 mm, 4.6 mm diameter, 5 µ column, using mobile phase 0.1 % of formic acid and acetonitrile by eluting in gradient with 1.0 ml flow, detection was achieved at 254 nm by maintaining 25 °C temperature for column. The method is validated as per the ICH guidelines. Linearity was recorded at various concentrations ranges 0.0100 – 6.0051 ppm for related substances A, B, C & 0.0040 – 2.4024 ppm of related substances D, E, F. Recovery RSD value of each related substance was <5.0 % (n=9). RS method for related substances in dipyridamole is found specific, linear, accurate, precise, rugged and robust hence the validated method is suitable to identify the related substances in dipyridamole...
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Posted by admin on Mar 31, 2020 in |
The study aimed at checking the effects of aqueous extracts of Vernonia amygdalina and Ocimum gratissimum on the electrolyte level of salt-loaded rats. 25 male rats weighing 160-220g were shared into 5 groups of 5 rats. Group 1 animals that were fed standard feed and water served as the control. Animals in group 2-5 which were salt-loaded orally with 2 ml of 4% sodium chloride solution for 2 weeks, were left untreated, treated with 1 ml of 300 mg/kg body weight of aqueous bitter leaf extract, 300 mg/kg body weight of aqueous extract of scent leaf and 300 mg/kg body weight of both extracts in ratio 1:1 respectively. Treatment of salt-loaded animals with the extract was done orally once daily for two weeks after which plasma electrolyte levels were determined. There was significant (P<0.05) increase in Na+ and Cl− levels in all the salt-loaded groups when compared with the control group. Bitter leaf extracts significantly (P<0.05) decreased the sodium level only when compared to the group with no treatment...
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