Posted by admin on May 31, 2020 in |
Introduction: an Inflammatory bowel disease is a group of chronic intestinal diseases characterized by inflammation of the bowel, the large or small intestine. The common types of inflammatory bowel disease (IBD) are ulcerative colitis UC and Cohn’s disease CD. Among the Asian countries, India is subjected to have one of the highest disease burdens of IBD across the globe. The number of IBD cases exceeds 12 lakhs annually, and an estimated 50 lakhs people are affected with IBD around the world stated by Indian statistics. Objective: To assess the quality of life in patients with inflammatory bowel disease and to associate with the sociodemographic characteristics of the patients. Materials and Methods: This was a prospective observational study carried out with 74 patients, and follow-up was conducted for 6 months at the outpatient clinic of Gastroenterology. A specially designed data collection form was utilized to collect patient’s demographic details and validated questionnaires to measure the quality of life. Results: Among 74 patients evaluated, there were an equal number of males...
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Posted by admin on May 31, 2020 in |
In the present research, the pharmacokinetic Drug-drug interactions between HMG-COA reductase inhibitors Pitavastatin with concomitantly used Ticagrelor have been studied. Pitavastatin is a member of the blood cholesterol lowering medication class of statins while Ticagrelor is a platelet aggregation inhibitor. Combination therapy with statins and other cardiovascular medications is recommended for patients at high atherosclerotic cardiovascular patient’s risk. The effect of Pitavastatin on the pharmacokinetics of Ticagrelor was studied on male Wistar rats divided into four different groups, I group is control group, II group of healthy rats administrated with Pitavastatin only in single-dose per day. III group of healthy rats administrated with Ticagrelor in a single dose per day and IV Group of healthy rats administrated with Pitavastatin and Ticagrelor in a single dose per day. The result evaluated by student’s paired T-Test and the results indicate no significant increase in peak plasma concentration of Pitavastatin (7.12 ± 2.12 ng/ml) and Ticagrelor (80.02 ± 3.03 ng/ml) when administrated alone or in combination (7.32 ± 1.12 ng/ml and 82.83...
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Posted by admin on May 31, 2020 in |
Present study was conducted to identify and characterize the phytoconstituents of methanolic extract of leaves of Tephrosia falciformis (Pers.) Ramaswami of family Fabaceae. The methanolic extract of leaves was subjected to qualitative screening for primary and secondary metabolites as per standard methods; further GC-MS analysis was carried out for the identification of secondary metabolites. The preliminary analysis of leaf extract confirmed the presence of primary as well as secondary phytoconstituents such as phenolic compounds, alkaloids, flavonoids, terpenoids, phytosterols, etc. in methanolic extract. GC-MS analysis of extract revealed the presence of 53 phytochemicals. The presence of various compounds with different chemical groups like quinolene, piperdinone (alkaloids), Neophytadiene (sesqueterpenens), phytol (diterpene alcohol), sitosterol, stigmasterol (sterols) and many fatty acids including their derivatives in considerable amount gives the good prospect for the use of this plant in pharmaceutical preparations to cure health-related...
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Posted by admin on May 31, 2020 in |
Cyanobacteria are a gram-negative group of microorganisms with unique features and found in diverse conditions of the environment. These tiny bio-factories are rich in pigment molecules like chlorophylls, carotenoids and phycobiliproteins. Studies on physiological and biochemical characteristics of different cyanobacterial strains will not only help to determine their biotechnological potential but also determine and interpret the appropriate growth conditions of these tiny microorganisms in their natural habitat. This paper focuses on the growth, chlorophyll, carotenoid and phycobilin production in two freshwaters (Anabaena cylindrica and Anabaena PCC7120), one halotolerant (Anabaena KP737864) and two marine cyanobacterial strains (Synechococcus BDUSM-13 and Nostoc BDUMM-70). Significant differences were observed among the strains with regard to their pigments. Maximum chlorophyll and phycobiliprotein content were observed on the 14th day of cultivation in all strains. The filamentous cyanobacteria Anabaena cylindrica recorded maximum production of phycocyanin, marine Synechococcus BDUSM-13 produced maximum phycoerythrin (17.33 µg/ml). Anabaena KP737864 was reported to acquire more amount of allophycocyanin (12.66 µg/ml) of...
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Posted by admin on May 31, 2020 in |
Ulcerative colitis is a subtype of Inflammatory Bowel Disease. The leaves of Syzygium cumini belonging to the family Myrtaceae were selected to evaluate its efficacy in ameliorating the acetic acid-induced Ulcerative colitis. Male albino Wistar rats were randomly divided into five groups. Group 1 was given the vehicle tween 80, group II received 2 ml of 4% acetic acid solution on 8th day intrarectally, group III was given 2 ml of 4% acetic acid solution once intrarectally on 8th day and 2mg/kg of prednisolone orally for 3 days starting from the day of acetic acid treatment. Group IV and V received 7 days pretreatment with 250 mg/kg and 500 mg/kg of ethanolic leaf extract of Syzygium cumini (SCEL), respectively, and 2 ml of 4% acetic acid solution once intrarectally on 8th day. Drug treatment was continued till 10th day. The rats were sacrificed on the 11th day, and the hematological, macroscopical and biochemical parameters were assessed. Pre-treatment with the extract improved the hematological parameters, body weight, and the stool...
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