Posted by admin on Apr 30, 2020 in |
Diclofenac is the most popular and widely prescribed non-steroidal anti-inflammatory drug (NSAID). However, no preclinical data are available on repeated diclofenac IV bolus injection. In the present study, forty male Wistar rats were randomly divided in in total of four groups with 10 rats in each group. The control group received 0.9% sodium chloride injection. Marketed injectable Diclofenac Sodium formulations of Jonac AQ (75 mg/mL), Dynapar AQ (75 mg/mL) and Voveran (75 mg/mL) were administered in group 2, 3 and 4 respectively @ 15.4 mg/kg body weight as IV bolus injection daily for seven days in the lateral tail vein. At the end of seven days treatment period, six animals per group were sacrificed. The remaining four animals per group were sacrificed after seven days recovery period. On day 8 of the study, 9/10 rats in the Voveran group, 10/10 rats in the Dynapar AQ group and 6/10 rats in Jonac AQ group showed an injection site reaction. On day 15 (reversal necropsy) of the study, 4/4 rats in...
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Posted by admin on Apr 30, 2020 in |
The present study was carried out to characterize the bioactive phytoconstituents from the fractions of F. elephantum fruit and to evaluate their in-vitro anti-diabetic activity. Column chromatography of methanol extract of F. elephantum fruit yielded Hexane: Ethyl acetate (1:1 v/v) fraction (HEFE), Ethyl acetate fraction (EFE) and Ethyl acetate: Methanol (1:1 v/v) fraction (EMFE), which were subjected to GC-MS analysis. They were also tested for in-vitro α-amylase and α-glucosidase inhibitory potential. GC-MS analysis of EFE predominantly showed 2,5-Furandione, dihydro-3-methylene; n-Hexadecanoic acid; 5-Eicosene,(E)-; cis-13-Octadecenoic acid; and γ-Sitosterol; 2,5-Furandione, dihydro-3-methylene-; cis-Aconitic anhydride; Ethanol, 2,2′-[(1-methylethyl)imino]bis-; and Propanedioic acid, ethyl-, diethyl ester; were the major compounds in EMFE. HEFE showed 2,5-Furandione, dihydro-3-methylene (18.5%), Dodecanoic acid (4.48%), n-Hexadecanoic acid (15.18%) and cis-13-Octadecenoic acid (18.95%) which are biologically active. Moreover, the α-amylase IC50 values of HEFE, EFE, and EMFE were 68.77, 52.59, and 40.28 μg/mL, respectively, while that of acarbose was 41.99 μg/mL. And the α-glucosidase IC50 values of HEFE, EFE, and EMFE were 69.53, 35.08, and 42.49 μg/mL, respectively, which were comparable to that...
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Posted by admin on Apr 30, 2020 in |
Lantana camara Linn. is an important ethnomedicinal plant with several medicinal properties. It is widely used in the traditional medicinal system as carminative, anti-inflammatory, antipyretic and respiratory system infections. The present investigation was carried out to determine the qualitative analysis of phytochemical screening and the presence of bioactive compounds from the hexanolic extract of Lantana camara leaves using GC-MS. The GC-MS analysis of hexanolic extract reported the presence of cis-Caryophyllene, caryophyllene oxide, isophytol acetate, 13-docosenamide, (Z) – and Squalene as major compounds. The presence of terpenes in extract confirms its application as anti-cancer, antioxidant and anti-microbial agents along with traditional medicine...
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Posted by admin on Apr 30, 2020 in |
Diltiazem HCl is a calcium ion channel inhibitor. The capacity to hinder the convergence of calcium ion present in of cardiac and vascular smooth muscle during membrane depolarization is accepted to be its therapeutic impact. It is broadly utilized in the treatment of a few kinds of cardiovascular disorders. For accomplishing better drug viability, unwavering quality success within the leading edge pharmaceutical structure, and targeted analysis, sustained-release drug delivery has touched toward changing into gauges. The biggest offer of drug delivery frameworks, for example, up to 80% of all the medication records to the OSRDD (Oral Sustained Release Drug Delivery). Sustained releases tablets of diltiazem HCl was planned to utilize Hydroxypropyl methylcellulose (HPMC 643), and povidone in various ratios, the extended-release conduct of fabricated tablets were then assessed. Sustained-release diltiazem HCl tablets were made by the direct compression method. The formulation was streamlined based on various tablet properties and drug release design in-vitro release profile. The subsequent formulation created tablets with required hardness, weight uniformity, and friability. The aftereffect...
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Posted by admin on Apr 30, 2020 in |
The phytochemical analysis of ethanol extract of Scurrula parasitica showed positive results for alkaloid, saponins, tannin, terpenoids, flavonoids, phenol, reducing sugar and phytosterols whereas glycoside is found to be absent. Total phenol and flavonoid contents were evaluated and found to be total phenolic compounds (101.9-379.1 µg/g tissue) and total flavonoids (72-174.1 µg/g tissue), respectively. The free radical scavenging activity of ethanol extracts of Scurrula parasitica (Loranthaceae) was determined to validate the medicinal potential of the plants. The antioxidant activity was performed by 2, 2-Diphenyl-1-picrylhydrazyl (DPPH) assay and ABTS + cation. The optimum concentration for both DPPH and ABTS was obtained at 100 µg/ml with an IC value of 53.28100 µg/ml and 160.8100 µg/ml, respectively. Therefore, the high content of both phenols and flavonoids might contribute to the anti-oxidative...
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