Posted by admin on Feb 29, 2020 in |
In the present work, temperature/pH-sensitive copolymer beads of chitosan (CS) coated sodium alginate/xanthan gum grafted N, N’-methylenediacrylamide have been synthesized by free radical polymerization in an atmosphere of nitrogen using AIBN/Fe2+ redox pair initiator and Tetramethylethylenediamine (TEMED) as a catalyst followed by simple ionotropic gelation technique. These beads were characterized by Fourier transform infrared (FTIR) spectroscopy, Differential scanning calorimetry (DSC), Field emission scanning electron microscopy (FESEM) Energy-dispersive X-ray spectra (EDS) and X-ray diffraction measurements (X-RD). DSC and X-RD studies reveal the molecular dispersion of Chlorthalidone (CT) drugs. Swelling and drug release behaviors of these beads were investigated in simulated intestinal fluid (pH 7.4) and gastric fluid (pH 2.0) at 37 ºC. Results illustrated that both the swelling and degradation of the optimized beads were influenced by the pH of the test medium, which might be suitable for intestinal drug delivery. The release mechanism was analyzed by fitting the release data into the Korsmeyer-Peppas...
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Posted by admin on Feb 29, 2020 in |
Floating drug delivery system comes with the advantage of sustained release of drugs over a prolonged period of time thereby maximizing the oral absorption of drugs with narrow absorption window, it overcomes the challenges of conventional oral drug delivery system. The aim of the present work was to develop a novel floating in-situ gelling system for sustained drug delivery of Clarithromycin for stomach ulcer. The in-situ gelling system were prepared by dissolving different concentrations of gelling polymers like sodium alginate, gellan gum in deionized water at 70 °C. After cooling to 40 °C fixed amount of drug, CaCO3 and released retardant polymer xanthan gum were dispersed with continuous stirring. All formulations showed pH in the range of 6.72 to 7.25, drug content was found to be in the range of 86.66% to 96.66%, floating lag time was <2 min, duration of floating was >12 h for all the formulations. It was observed that viscosity of solution increases with an increase in polymer concentration. In-vitro drug release was found to...
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Posted by admin on Feb 29, 2020 in |
A stability-indicating RP-HPLC method for the simultaneous determination of emtricitabine (EMT), tenofovir (TNF), cobicistat (COB) and elvitegravir (ELV) in solid dosage forms. The waters 2695, High-Performance Liquid Chromatographic system with column kromasil C18, 250 × 4.6 mm, 5 µ. The detector used is PDA detector at 288 nm. The mobile phase used in this method is pH-3.5 phosphate buffer and acetonitrile in the ratio of 60:40% V/V. Flow rate used for this proposed method is 1.0 ml/min. The retention times observed are 2.304 min, 2.691 min, 3.185 min and 4.537 min for emtricitabine, tenofovir, cobicistat, and elvitegravir respectively. The linearity calculated was found to be within the range. The % recoveries for EMT, TNF, COB and ELV were within the acceptance criteria. These drugs were found to be stable at forced degradation studies and results are within the limits. The proposed method can be used for the quality control of the combination in the pharmaceutical dosage...
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Posted by admin on Feb 29, 2020 in |
Obesity is a very serious health problem worldwide. Obesity depends on several physical and bio-chemicals parameters that are discussed in this work, i.e., BMI, cholesterol level that includes Total cholesterol (TC), High density lipoprotein concentration (HDL-c), Low density lipoprotein (LDL-c), Triglycerides level (TG), Glucose level, Postprandial glucose level. The present study throws light on the, efforts being made to find out the prevalence of obesity over different anthropometrical and biochemical parameters. Anthropometrical parameters were considered in the school going children from families financially poor or with bound, while the biochemical parameters were performed on subjects from age group from 16 to 70 years. Many questions were asked in the form of a questionnaire related to their lifestyle. Anthropometrical data from school going children showed 11% obesity and overweight. Biochemical data showed 20.27% persons were having a TC level, 46.08% having HDL-c, 19.35% having LDL-c, 29.05% having TG, 36.48% having fasting glucose level and 37.18% having a postprandial glucose level higher than the threshold values. Henceforth, the results explained the...
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Posted by admin on Feb 29, 2020 in |
The objective of the present investigation was to develop topical curcuminoids containing gel as an anti-inflammatory. The first gel base was prepared by using various different concentrations of Carbopol 934, Propylene glycol 400, Methylparaben, Propylparaben, and required amount of distilled water. The optimized base was selected for the incorporation of different concentrations of curcuminoids (CM) and fixed concentration of tulsi oil (TO) and eucalyptus oil (EO). Then skin pH (6.8-7) was maintained by the dropwise addition of tri-ethanolamine. Prepared formulations were evaluated for physical appearance, pH, spreadability, viscosity, and homogeneity. Prepared formulations have proceeded for skin irritation on an animal model (rabbit). All gels were evaluated for anti-inflammatory activity by using carrageenan-induced rat paw edema model on Albino Wistar rats of either sex (150-200 gm). Change in edema volume of the rat hind paw was measured, and percent inhibition was calculated. Stability studies have carried out as per ICH guidelines for 3 months at different temperatures and humidity. Results reveal that all formulations have shown good appearance, homogeneity, and...
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