Posted by admin on Mar 31, 2020 in |
To increase the solubility of poorly water-soluble drug simvastatin using hydrophilic carrier poloxamer 188 using solid dispersion techniques by microwave irradiation method. The microwave irradiation technique was used to prepare solid dispersions in minimum time interval in different drug carrier ratios, i.e. 1:2, 1:5, 1:8 and was subjected to microwave for different times, i.e. 3 min, 5 min, and 7 min. Solid dispersions were characterized for drug content, percentage yield, saturation solubility studies, and in-vitro dissolution studies. A 32 full factorial design was selected to study the influence of the individual and combined effect of independent variables drug carrier ratio (X1) and microwave time (X2) on the dependent variables percent dissolution efficiency (% DE) at 60 min and percent yield. In this design, two factors were evaluated, each at three levels, and experimental trials is performed at all nine possible combinations. The optimized batch obtained using design expert was having drug carrier ratio of 1:5.75 and microwave time of 5.68...
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Posted by admin on Mar 31, 2020 in |
Pharmaceutical analysis is the application of principles of analytical chemistry to drug analysis. The analytical chemistry is the science of developing accurate, precise, and sensitive methods for determining the composition of materials in terms of elements or compounds which they contain. Quality means confirming specifications and standards, and it is never an accident; it is a result of intelligent efforts. Quality assurance influences the quality of the product and plays a central role in assuring the quality, safety, purity, and effectiveness of the drug products. Estimation of amoxicillin and carbocisteine in their combined dosage form were done. Official books also do not provide methods for simultaneous analysis. Most of the methods available for the analysis of active ingredients of such formulations are applicable only after prior separation, which makes it tedious and time-consuming and also a costly affair. In experimental work trials of various mobile phases, Analysis of laboratory mixture by proposed method carried out. The calibration curve was found to be linear in the concentration range of 5-25...
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Posted by admin on Mar 31, 2020 in |
The present study was carried out to evaluate the gastroprotective effect of melatonin, coenzyme Q10 (CoQ10) and its combinations with rabeprazole in aspirin (400 mg/kg) and ibuprofen (300 mg/kg) induced gastric ulcers in albino Wistar rats. In aspirin-induced gastric ulcer model, the treatment of melatonin (20 mg/kg), CoQ10 (100 mg/kg) and rabeprazole (20 mg/kg) for 10 days significantly reduced the ulcer index with the values of 1.333 ± 0.30, 1.250 ± 0.2 and 0.916 ± 0.18 respectively whereas the ulcer index of combination treatment of melatonin with rabeprazole and CoQ10 with rabeprazole for 10 days was found to 0.416 ± 0.12 and 0.250 ± 0.11 respectively compared with control wherein the ulcer index was 2.88 ± 0.16. In ibuprofen induced gastric ulcer model, the treatment of melatonin (20 mg/kg), CoQ10 (100 mg/kg) and rabeprazole (20 mg/kg) for 10 days significantly reduced the ulcer index with the values of 1.500 ± 0.21, 1.417 ± 0.15 and 0.833 ± 0.27 respectively whereas the ulcer index of combination treatment of melatonin with...
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Posted by admin on Mar 31, 2020 in |
Nutraceutical term is a combination of terms nutrient and pharmaceutical. There is a wide scope in applying pharmaceutical formulation parameters to nutraceuticals. Amongst the variety of nutraceuticals available, powder form of nutraceuticals are most popular. The nutraceutical powder mixtures can contain many ingredients, of which the nutrient source contents are generally present in more than 50% of whole formula. Optimization of the powder formulations for pharmaceutical and organoleptic parameters is the needed approach. Under this study optimization, evaluation, and stability study of nutraceutical powder formulations developed from edible seed and leafy vegetable sources is done. The research done involves development of two nutraceutical powder formulations one from edible seed sources namely – Cucumis melo, Punica granatum and Linum usitatissimum in 1:1:1 proportion, and second from green leafy vegetable sources namely Trigonella foenum graecum, Coriandrum sativum, Raphanus raphanistrum and Anethum graveolens in 1:1:1:1 proportion. The seeds and leafy vegetables selected were screened for macro and micronutrient content, prebiotic and antioxidant potential. Its in-vivo effect is measured as blood parameters and...
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Posted by admin on Mar 31, 2020 in |
Complementary and alternative medicines (CAMs), particularly herbal medicines (HMs), are popular with diabetic patients and are often used alongside conventional treatments. In such cases, patients usually do not advise their doctor or any other healthcare professional, so inappropriate use and potential interactions between CAM therapies and conventional treatments are serious concerns. This study attempted to identify the main factors affecting CAM decision-making by studying the association between CAM use and patient characteristics, including age, gender, diagnosis, reasons for using, time of starting, and sources of HM products. It was aimed to shed light on patients’ experiences and perceptions of CAM use, particularly HMs, to identify any perceived benefit or harm. Cross-sectional questionnaire surveys, including open-ended and closed-ended questions, which were administered to eligible participants. The results revealed that approximately 34% of the 98 patients participating in the study used CAM. The most prevalent age group of participants was 51-60 years old (39.8%). The most used HMs were the olive leaf (21.2%), green tea (21.2%), cinnamon (21.2%), black seeds (15.2%),...
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