Posted by admin on Feb 29, 2020 in |
The objective of the present study was to formulate and evaluate microspheres of Glipizide using guar gum and HPMC K4M as polymers for colon-specific delivery for better treatment of Type 2 diabetes. The glipizide microspheres were prepared by ionotropic gelation method by the use of various cross-linking agents. The microspheres were then studied for physical appearance, particle size, surface morphology, drug-polymer compatibility, and drug entrapment efficiency. The in-vitro drug release profile was studied in three different buffer medium using USP type I apparatus. Further, kinetic modeling was employed to find out the release mechanism. Glipizide microspheres showed high entrapment efficiency (89.80%) and the microspheres were free-flowing, non aggregated, and almost spherical between 500-700 μm in diameter. The FTIR spectrum showed that there is no interaction between the polymers and drug. The in-vitro release study found to be affected by using various cross-linking agents. The microspheres with barium chloride as cross-linking agents showing a small amount of drug release in acidic pH but show maximum drug release at the end...
Read More
Posted by admin on Feb 29, 2020 in |
In the present study, the larvicidal activity of successive n-hexane, chloroform, ethyl acetate and ethanol extracts of Epaltes pygmaea DC (Family: Asteraceae) whole plant was carried out against three mosquito species namely Culex quinquefasciatus, Aedes aegypti L. and Anopheles stephensi. The crude whole plant was successively extracted with n-hexane, chloroform, ethyl acetate, and ethanol. The larvicidal activity was studied at 62.5 ppm, 125 ppm, 250 ppm, and 500 ppm concentrations against the late third instar larvae of C. quinquefasciatus, A. aegypti and A. stephensi. Results showed that the ethyl acetate extract of E. pygmaea was the most effective against tested mosquito larvae. The median lethal concentration (LC50) values of ethyl acetate extract were calculated as 35.79 ppm, 62.37 ppm and 29.94 ppm for C. quinquefasciatus, A. aegypti and A. stephensi, respectively. The results suggested that ethyl acetate extract of E. pygmaea could be used to control C. quinquefasciatus, A. aegypti and A....
Read More
Posted by admin on Feb 29, 2020 in |
Pulsatile drug delivery is one such system thereby delivering drug at the right time, right place and in right amounts and holds good promises and provides benefit to the patients suffering from chronic problems like arthritis, asthma, hypertension, etc. The present study investigated that optimization of quinapril hydrochloride was successfully done and batch A8 was given satisfactory results. Tablets of quinapril hydrochloride were made by direct compression method. Microcrystalline cellulose was used as direct compressing agent. Sodium starch glycolate used as disintegrating agent and croscarmellose sodium used as super disintegrating agent. The resulting powder mixtures were then compressed into tablets using KBR machine. Dry coating using different concentrations of HPMCK4M, EC, and HPMCK100M. Also magnesium stearate and spray-dried lactose. Dry coated pulsatile tablet was prepared by placing 50% pulsatile release layer in 13 mm die and core tablet was placed on it. A1 to A 5 show less lag time, less in-vitro buoyancy study due to less concentration of polymer. Where A 7 gave drug release after 8 hours...
Read More
Posted by admin on Feb 29, 2020 in |
The aim of the present work was to formulate and evaluate Fast Dissolving Tablet (FDT) of a combined oral dosage form of Paracetamol (PCM) and Chlorpheniramine Maleate (CPM). Paracetamol is an antipyretic and Chlorpheniramine maleate is an antihistamine used to relieve symptoms of hay fever, allergy, and the common cold. Combining both the drugs can be used as pain-relieving and fever in cold and flu conditions. Three super disintegrating agents such as Cross Carmellose Sodium (CCS), Sodium Starch Glycollate (SSG) and Microcrystalline Cellulose (MCC) at different concentrations were used to enhance the disintegration and to improve the bioavailability of the drugs. By using the direct compression method, the FDT’s were prepared and evaluated for hardness, weight variation, wetting time, friability, disintegration time, in-vitro dissolution study, Thermogravimetric Analysis (TGA), and stability studies. A new Spectrophotometric method was developed for simultaneous estimation of PCM and CPM in FDT. Among all six formulations, F2 with CCS 27% concentration found the best formulation. F2 resulted in best wetting time i.e. 26 sec, good...
Read More
Posted by admin on Feb 29, 2020 in |
Carboplatin is the first-line choice of drug for ovarian cancer. In this investigation, we have prepared carboplatin silver nanoparticles (CSNP’s) by electrostatic adsorption. The size range was found to be 53-87 nm and the zeta potential was in the range of -36 to -61. After coating with hyaluronic acid and drug the size was observed to be around 80 nm and zeta potential was -41. After coating the monodisperse particles with a narrow polydispersity index value of 0.49-0.51 were obtained. The pH of silver nanoparticles without coating was in between 5.1-5.9. Atomic force microscopy confirms the spherical shape of nanoparticles. The entrapment was found to be 70-87%. Formulation F3 was found to have more entrapment efficiency and the release extended up to 6 h in phosphate buffer saline pH 7.4. The uniform concentration of trisodium citrate and tannic acid as a reducing agent along with high concentration of hyaluronic acid in F3 formulation able to entrap high drug load and release for an extended period. The drug release follows...
Read More
