Posted by admin on Jan 31, 2020 in |
Niosome is one of the synthetic nanoparticles which often is used for drug delivery and cosmetic industry. The aim of this study was to prepare niosomes encapsulated with KT2 and RT2. KT2 and RT2 are antimicrobial and anticancer peptides derived from crocodile leukocyte extract. Niosomes encapsulated with KT2 and RT2 were prepared by thin-film hydration technique, and peptide encapsulation efficiency was evaluated. Niosome particle size, size distribution, and surface morphology were also studied. The results show that KT2 and RT2 were successfully loaded in the formulations with encapsulation efficiencies of 70.9 ± 0.9% and 59.6 ± 3.4%, respectively. The mean particle size and zeta potential of KT2 and RT2 encapsulated niosomes were 9.3 ± 1.13 µm and – 57.39 ± 2.53 mV and 9.1 ± 0.03 µm and – 50.91 ± 2.28 mV, respectively. Niosomes had spherical shapes with rough surfaces. Niosomes coated with hydroxypropyl methylcellulose phthalate (HPMCP) were evaluated for pH stability. At pH 1.2 and 4.5, the peptide-encapsulated niosomes were stable. In conclusion, these peptide-encapsulated niosomes have...
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Posted by admin on Jan 31, 2020 in |
Objective: Lepidium sativum (Garden cress) is traditionally an important plant with a wide range of activities from the ages. Ample literature about its biological activities, motivate us to evaluate the total flavonoids content and to screen the nootropic activity in mice. Methods: Ethanolic extract was prepared from the seeds of Lepidium sativum using ethanol (70% v/v) and total flavonoids content was estimated by using Zhishen method. The ethanolic extract was screened for its acute toxicity and nootropic activity by elevated plus maze (EPM) and morris water maze (MWM) test in mice. Results: The results showed that the ethanolic seed extract of the plant is having a good amount of flavonoids (17.54 ± 47 of gram equivalence of rutin at 510 nm) and also exhibited significant increase in memory and learning abilities. Conclusion: To conclude, the flavonoids that are present in the ethanolic extract may be responsible for the exhibited activity and it is regarded as safe to administer to the animals. Moreover, further studies are necessary to explore its...
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Posted by admin on Jan 31, 2020 in |
Fossil fuels are significantly depleted nowadays due to excess utilization. Therefore, it is always better to find alternatives to produce eco-friendly fuels. This paper deals with the production of biodiesel from agro-industrial waste such as young coconut husk, custard apple seeds and broiler chicken skin. Lipids were isolated from the substrates using the modified Bligh and Dyer method and transesterification was conducted to the isolated lipids in an inert condition to produce biodiesel. Obtained biodiesel was characterized by Gas Chromatography-Mass Spectroscopy (GC-MS) and confirmation of esters was done using Fourier Transform Infrared (FTIR). This study encourages the production of biodiesel from waste plant and animal...
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Posted by admin on Jan 31, 2020 in |
The drug Parpataka is used particularly for the treatment of fevers, indigestion, biliousness, burning of the body, tired feeling, giddiness, urinary discharges, vomiting, thirst, enriches the blood and works good in leprosy. The present study is intended to authenticate and validate the species of Peristrophe paniculata (Forssk.) Brummitt, which is one of the sources of the Parpataka drug used in Ayurvedic and Siddha systems. The objective of the present work was to assess and established the various pharmacognostical properties like; macroscopical, micro-scopical (cell structure and their arrangement), physicochemical (including different ash values, loss on drying and extractive values), fluorescence and preliminary phytochemical profiles of the leaf, stem and roots of the plant. Qualitative tests for various functional groups were also carried out. The pharmacognostical screening of Peristrophe paniculata on different standardization parameters may prove to be very useful for the correct identification of the genuine drug and also to determine the quality and purity of the plant material to be used in different Ayurvedic...
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Posted by admin on Jan 31, 2020 in |
Objective: The purpose of the study is to pursue some heavy metals in the aqueous environment of Tigris river that passes through Mosul city prior to the bioaccumulation of such metals in catfish Silurus glanis and its intestinal tapeworm Postgangesia armata. Methods: Silurus glanis, a freshwater fish were hunted from Tigris river passing through Al-Rashidiya region/Nineveh Governorate, North Iraq, during November 2017 and May 2018. Bioaccumulation of Fe, Cr, and Mn were estimated in different body tissues of infected and uninfected catfish, and in catfish intestinal tapeworm P. armata. Atomic absorption Spectrophotometer was used to estimate heavy metal concentration as µg of a particular metal/gm of fresh weight. Results: Concentration of the metals in catfish tissues were in the order of Mn > Fe > Cr. Whereas, concentration of the metals of the tapeworm P. armata were in the order: Fe > Mn > Cr. Moreover, mean concentrations of the three heavy metals (Cr; Fe and Mn) were lesser in body tissues of infected catfish than in the uninfected...
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