Posted by admin on Mar 31, 2020 in |
In this study, attempts were made to evaluate the anti-microbial activity of the galls of Quercus infectoria Olivier against oral bacteria causing dental caries. Various solvents systems were used to screen the potential of the extract on the clinically isolated organism and reference strains; Candida albicans MTCC 183, Streptococcus mutans MTCC 497, Lactobacillus acidophilus MTCC 10307 and Staphylococcus aureus MTCC 1144 using agar-well diffusion method. This was followed by determination of minimum inhibitory concentration (MIC) by using two-fold serial microdilution methods at a concentration ranging between 0.02 mg/ml to 10 mg/ml. The MIC values against each bacterial species was found in the range of 0.16 to 0.31 mg/ml. Minimum bactericidal concentration (MBC) was obtained by subculturing microtiter wells which showed no changes in color of the indicator after incubation. Among all tested bacteria, S. aureus was the most susceptible. The clinically isolated S. mutans was further analyzed for its ability to form biofilm on the surface of seashells. The biofilm reduction percent assay in microtitre wells was used to...
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Posted by admin on Mar 31, 2020 in |
A series of novel 2-{[6-(2-substituted Phenyl)-2-oxo-1, 2-dihydropyrimidin -4-yl]oxy} benzoic acid (2a-b)/ 2-{[6-(2-substituted Phenyl)-2 thioxo-1, 2-dihydropyrimidin-4-yl]oxy} benzoic acid (2c-d) were synthesized and tested for their in-vitro protein denaturation activity. Compound 2d was found to be promising and was more potent than the Acetylsalicylic acid (NSAID) in the inhibition of Bovine serum albumin denaturation. The purity of the compounds was checked by TLC and elemental analyses. Both analytical and spectral data (1H NMR, IR, and MS) of all the synthesized compounds were in full agreement with the proposed...
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Posted by admin on Mar 31, 2020 in |
The purpose of current research work is to evaluate the in-vitro antioxidant and in-vivo hepatoprotective activity of Ganoderma lucidum strains DARL-4 and MS-1. Antioxidant activity of different extracts was evaluated by using DPPH and ABTS method. Hepatoprotective activity of hydroalcoholic extract of G. lucidum strain DARL-4 and MS-1 were evaluated by paracetamol-induced liver damage in rats. The hydroalcoholic extract of DARL-4 and MS-1 were orally administered to the animals at a dose of 300 mg/kg once daily for 14 days. On the 14th day the paracetamol (2 g/kg) was also orally administered. The degree of protection was measured by estimating the serum biochemical parameters. The result showed that the hydroalcoholic extract of DARL-4 and MS-1 showed potent antioxidant activity than the ethanolic, methanolic and aqueous extract. The serum biochemical parameters which were elevated due to paracetamol toxicity were significantly reduced. The histopathological studies also supported that extracts markedly reduced toxicity of paracetamol. The hydroalcoholic extract of MS-1 showed a more potent hepatoprotective effect than that of DARL-4. The present...
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Posted by admin on Mar 31, 2020 in |
Formulation development for new drugs, an extension of formulations, finding an alternative to conventional dosage forms for better therapeutic response are some of the research impetus in Pharmaceutical F and D. The new -untried routes of administration are also an avenue that can be explored. Under this research zolmitriptan, an antimigraine, BCS class II drug is formulated into mucoadhesive films. Zolmitriptan shows 40 to 50% oral bioavailability owing to its low solubility and degradation in GIT. Mucoadhesive films can be an effective formulation for this drug owing to its good permeability. Direct absorption in blood and preventing GIT degradation by mucoadhesion on buccal mucosa can be two rationales stated for the improvement of bioavailability of zolmitriptan via mucoadhesive films. Migraine strikes as abrupt and disturbing health situation and needs immediate treatment. Thus, the mucoadhesive film can be more promising than oral tablets for zolmitriptan in the treatment of migraine. Blank mucoadhesive films were prepared using various combinations of. HPMC K15, Eudragit L 100, whereas concentrations of chitosan, PVA, beta-cyclodextrin,...
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Posted by admin on Mar 31, 2020 in |
The emerging need for the multidrug regimen of M. tuberculosis strains urged us to synthesize novice and potent anti-tubercular medicaments. Our interest in this work had afforded a series of novice cinnolines as a new structural category of antituberculosis agents. All 14 compounds were synthesized using the appropriate scheme, two-step reactions with the high yielding product. The newly synthesized cinnoline Compounds were examined for their in-vitro drug-sensitive M. tuberculosis H37Hv strain. To date, evaluation of anti-tubercular activity various drugs in the multidrug regimen is on going out of which INH highly effective component drug and is advised by WHO. Some of the derivatives were considered to be promising inhibitors of M. tuberculosis. For example, the most active compound (CN-14) exhibited 12.5 μg/ml inhibitions against drug-sensitive M. tuberculosis H37Rv...
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