Posted by admin on Dec 31, 2019 in |
The main objectives of the present study were to design, optimization and evaluation of buccal drug delivery system of propranolol for hypertension treatment. Propranolol is non-selective β-adrenergic blockers. It shows first-pass metabolism so its bioavailability is decreased and its absolute bioavailability is only about 26%. The buccal tablets of propranolol formulated, by using different mucoadhesive polymers such as sodium crosscarmilose sodium, PVP K30, and HPMC K15M. F8 was containing 18.18% PVPK30, 10.90% HPMC K15M showed desired drug release within 6 h to above batches. The dissolution profile of formulated batch F1 to F8 at the end of 6 h was found in the range of 83.03 to 94.69% in phosphate buffer pH 6.8. From the results, it was found that formulation F8 was shown most similar dissolution profile because the similarity value was found to be above 90%. The swelling index was found higher in formulation F9 80.15% swelling observed because of higher concentration of PVP K30 and HPMC K15M. The results indicate that out of two bioadhesive polymers...
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Posted by admin on Dec 31, 2019 in |
Cymbopogon olivieri (Poaceae) is a native plant to the south of Iran and is used for the treatment of some inflammative based disorders and as a pain killer. Regarding the presence of volatile terpenoids in the aerial parts, we were prompted to investigate the analgesic and anti-inflammatory activities of the essential oil from C. olivieri in animal models. The oil was also analyzed by GC and GC–MS to identify the potentially responsible compounds for observed properties. The analgesic activity of the oil was assessed by acetic acid-induced writhing test and hot plate method while the acute anti-inflammatory effect was investigated by induced-inflammatory paw edema in the rat. The studied oil could decrease the number of acetic acid-induced writhes in mice compared with animals that received vehicle only. In hot-plate tests, the studied doses of C. olivieri were not effective. The oil moderately reduced carrageenan-induced paw edema in rats. The major component of the oil was characterized as Piperitone (66.0%), which might be responsible for these observed activities. The results...
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Posted by admin on Dec 31, 2019 in |
The vast investigations on the derivatives of 1, 2, 3-benzotriazole explore wide applicability for tagging and delivering a number of other heterocyclic nuclei with benzotriazole. In the present work, several derivatives of 1-(substituted)-5- [(N-benzotriazolo-methyl)-1, 3, 4-thiadiazolyl]- imidazole-2-thione have been synthesized and are evaluated for their anticonvulsant activity. The anticonvulsant activities of the synthesized derivatives were assessed by the maximal electroshock (MES) method. Electric shock (50 mA for 0.2 sec) was delivered with the help of a corneal electrode to induce hind limb tonic extension. The synthesized derivatives X2, X3 and X6 exhibited significant anticonvulsant effect against MES-induced seizure model as an indication for compounds which are effective in grand mal...
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Posted by admin on Dec 31, 2019 in |
A bird is often subjected to dysbacteriosis with a low quality of feed. As a result, live weight gain and livability are reduced in broilers. This problem has become particularly acute now when most countries have abandoned the use of feed antibiotics. Significant assistance in this situation is provided by new regulators of intestinal biosynthesis – probiotics. In our research, we used biosporin produced by the Military and Technical Problems Centre of the Research Institute of Microbiology of the Russian Ministry of Defense. Scientific and household experience was conducted on the basis of ZAO “Ural broiler”. Three groups were formed: one control group and two experimental ones. There were 100 units in each group. The results of scientific and household experience lead to the conclusion that biostim is more preferable with the comparative use of two liquid probiotic products from the point of view of production figures. Feeding it to a bird in accordance with the instruction allows increasing the live weight of broiler chickens by 11.5%, reducing the...
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Posted by admin on Dec 31, 2019 in |
A series of hydrazide-hydrazones (3a-o) have been synthesized by the reaction of acid hydrazide (2) which is obtained from 4-carbomethoxy-2-aminophenol with aromatic acid through multi-steps. The bioactivities of the final compounds were tested with MES and scPTZ methods. The CNS toxicity was studied by the rotarod experiment. Based on the results, compounds 3d and 3o were found to be most active at 30 mgkg-1 in the MES test with prolonged duration of action; they exhibited activity comparable to standard drugs phenytoin and carbamazepine. Compounds 3f, 3j and 3m exposed toxicity (300 mgkg-1) at 0.5 h of the time period and compounds 3i, 3n and 3o exhibited late toxicity after 4.0 h as compared to carbamazepine. The rest of the compounds did not face toxicity at a maximum dose level (300 mgkg-1). This study shows that increased lipophilicity is directly related to the anticonvulsant activity. Further studies need to be carried out on other seizure tests and models of epilepsy to ascertain the precise mechanism of action of these...
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