Posted by admin on Feb 29, 2020 in |
In the present study novel matrix diffusion controlled transdermal patches of Hydralazine hydrochloride, a hypertensive drug to ensure satisfactory drug release were successfully prepared by solvent casting method with optimization of suitable polymeric blend of Eudragit L100 (EL-100), ethyl cellulose (EC), polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), carbopol, hydroxypropyl cellulose (HPC) to achieve sustained release pattern within the therapeutic range. N-dibutyl phthalate (n-DB) used as a plasticizer and oleic acid used as a permeation enhancer. Different batches of transdermal patches were prepared by varying different polymers with the difference in ratio. Prepared transdermal patches from each batch, gave release profile for over 12 h. Fourier Transform Infrared analysis shows no interaction between drugs and polymers. Cumulative amount of drug release in 12 h from all the prepared formulation were found to be in following order: F1> F2> F3> F4> F9> F8> F7> F10> F5.F6. Combination of Eudragit L100 and PVP (F1 and F2) and Ethylcellulose and PVP (F3 and F4) exhibited good characteristics for sustained release...
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Posted by admin on Feb 29, 2020 in |
Inflammation is a normal, protective response to tissue injury caused by physical trauma, noxious chemicals or microbiological agents. Medicinal plants and their secondary metabolites are progressively used in the treatment of diseases as complementary medicine. In the present study methanolic extract of flower heads of Tagetes erecta was screened for its phytochemical constituents and then subjected for its anti-inflammatory activity by using in-vitro and in-vivo methods. The preliminary phytochemical investigation of methanolic extract of flower heads of Tagetes erecta showed the presence of flavonoids like quercetin, kaempferol, gallic acid, syringic acid, terpenoids like β-amyrin, erythrodiol, steroids like β-sitosterol, β-stigmasterol, phenols, and alkaloids. The methanolic extract of Tagetes erecta (METE) significantly (p<0.05) inhibited the paw oedema volume. The extract significantly (p<0.05) protected protein membranes from denaturation. To understand the ligand-binding affinity of the above constituents with COX-2 the constituents were subjected to molecular docking studies using ligand fit of maestro 9.1 (Schrodinger Software Inc.). Amongst the constituents identified kaempferol, quercetin, gallic acid were found to possess strong binding affinity towards...
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Posted by admin on Feb 29, 2020 in |
The pigment has acquired the greatest importance because of its excellent color value. The potential use of various carbon sources as microbial pigments for textile coloration. Flowers, leaves, fruits, vegetables, and tubers are the rich source of the secondary metabolites. In the current study, the use of microbial extract isolated from a fermentation process from 14 varieties by using Penicillium purpurogenum as a natural dye was studied. The potentiality of the dye extract was classified by dyeing with 100% cotton under suitable conditions. The dye ability, colorfastness (wash, light, rubbing) and Munsell color value, hue, L, a, b of dyed liquids were studied by using computer color matching software were studied. The color of the dye was not affected by washing. The results reveal that Hibiscus rosa sinensis, Ixora coccinea and Nerium oleander having highest K/S values. It could be seen that P. purpurogenum responded by producing high concentrations of pigment from Tagetes patula flower (crude) than the other combinations. It is to their ability for the formation of...
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Posted by admin on Feb 29, 2020 in |
Fixed-dose combinations are defined as a combination of two or more active ingredients in a fixed ratio of doses. Recently fixed-dose combinations are more rapidly marketed; the available combinations in the market include both rational and irrational. The use of irrational fixed-dose combinations has resulted in severe adverse drug reactions and a reduction in patient quality of life. The main objective of this study was to assess the prescribing patterns and rationality of fixed-dose combinations in a tertiary care teaching hospital. A prospective and observational study was conducted in 249 inpatients after taking written consent from those who meet study criteria in the Medicine and Pediatric department for a period of 6 months. In this study, the combinations of drugs were equally distributed to both females and males patients (50%), most patients were in the age group of 70-79 (20%). A total of 355 combinations of drugs were used belonging to 48 different combinations. The most commonly prescribed combinations were Aspirin + Atorvastatin (13%) and Tramadol + Acetaminophen (12%)....
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Posted by admin on Feb 29, 2020 in |
Ciprofloxacin is a class of broad-spectrum fluoroquinolone antibacterial agent and produces a synergistic effect in combination with Curcumin. In the present research work, we have developed a new analytical method for the determination of Ciprofloxacin and Curcumin in its bulk powder. The UV-spectrophotometric method was developed by utilizing a solvent system composed of methanol: water (50:50 v/v). Ciprofloxacin and Curcumin showed maximum absorbance wavelength at 275 nm and 430 nm respectively. The method was optimized and validated in terms of specificity, selectivity, linear range, precision, robustness, ruggedness, reproducibility and solutions stability as per ICH guidelines. Analytes showed a linear response between the concentration ranges of 1-6 µg/mL. This method was found to be precise, robust, rugged and reproducible with % RSD values less than 2%. Hence, a newly developed, optimized and validated UV-Spectrophotometric method was found to be simple, selective, specific, linear, precise, robust, rugged, reproducible and economical and can be used for simultaneous determination of Ciprofloxacin and Curcumin in bulk drug...
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