Posted by admin on Nov 30, 2019 in |
As a part of our ongoing effect to develop a biodegradable medicated film for wound healing using chitosan and HPMC as polymers. The drug used is Silver sulfadiazine. This formulation produces better biodegradability and bioadhesion. The biodegradable film is non-toxic and non-irritant to the skin. An animal wound model was performed on the back of the rats and treated, respectively with medicated biodegradable film and with a marketed product. There are no infections found during the period of study. The wound healed within 6 days, in the case of medicated film formulation, but not with the marketed cream. Medicated films could be a good alternative to conventional wound dressings, which is painful and injurious. The film adheres to open wounds, and therefore it is good protection providing a moist healing environment. Better patient compliance is an added advantage as it does not require repeated...
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Posted by admin on Nov 30, 2019 in |
Objective: The objective of the study was to estimate the effects of Non-caloric Artificial Sweeteners (NAS) on glycaemic status in male Swiss albino mice. Methods: 36 male Swiss albino mice were selected and divided into six groups of 6 animals each. Group 1 served as control and received a normal pellet diet with drinking water. Groups 2, 3, 4, 5 and 6 received normal pellet diet and drinking water along with oral administration of Glucose, Saccharin, Sucralose, Aspartame, and commercial Aspartame, respectively for 8 weeks. Bodyweight of the animals was measured every week from baseline until the end of the experiment. Fasting blood glucose, serum glycated hemoglobin (HbA1c), serum insulin, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), renal function tests, liver enzymes, fecal culture, and lipid profile were assessed during baseline and end of the study. Results: The bodyweight of the animals was increased in all groups. Fasting blood glucose and HbA1c were significantly increased in NAS groups. Saccharin group showed increase in serum insulin, HOMA-IR, liver enzymes, urea,...
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Posted by admin on Nov 30, 2019 in |
Nanoparticles are of great scientific interest, in fact, a bridge between bulk materials and atomic or molecular structures. The main characteristic of nanoparticles is their extreme smaller size, which falls in the transitional zone between molecules and the corresponding bulk materials. Lipids and fatty acids are a family of molecules classified within the lipid macronutrient class. The present study is based on the changes in lipid profile parameters due to Hg-Se NPs. Both mercury and selenium have a binding affinity for each other. Mercury is comparatively toxic than selenium; hence in combination, selenium works antagonistically to mercury. Acute and sub-acute treatments of mercury selenide nanoparticles (Hg-Se NPs) reflect changes in lipid profile in female Albino rats, which may be considered in cardiac risk assessment and its follow up program. The level of cholesterol, triglycerides (TG) and lipoprotein were found to be reduced after acute (1 day) and sub-acute (7, 14, and 21 days) treatments. The reduction in cholesterol and triglycerides revealed quick penetrating power of Hg-Se NPs whereas decrement...
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Posted by admin on Nov 30, 2019 in |
Low level of oxygen in tissues leads to hypoxia, and hypoxia-inducible factors (HIF) regulate the hypoxic and normoxic conditions in various tissues. During normoxia, HIF-1α binds to von Hippel-Lindau E3 ubiquitin ligase complex that targets HIF-1α to the ubiquitin-proteasome pathway for proteolytic destruction. But in hypoxia, HIF-1α move to the nucleus where it binds to CBP/p300 at CH1 domain. By considering this fact, the present study was conducted to search a suitable inhibitor that can bind to HIF-1α. The unliganded HIF-1α was docked and the best five docking solutions complex were selected and analyzed by Ligplot. The analysis showed that catechin, epicatechin, myricetin, dicarnoxide D, and pycnidione had the maximum potential to inhibit HIF-1α protein and may prove to be potential inhibitor for counterfeiting hypoxic...
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Posted by admin on Nov 30, 2019 in |
The effect of a wide range of culture conditions on the production of laccase (Lac), Lignin peroxidase (Lip) and Manganese peroxidases (MnP) by Daedaleopsis confragosa was studied. A ligninolytic enzyme-producing bracket mushroom, Daedaleopsis confragosa was isolated from tree trunk from Karwar coastal region, Karnataka, India and subjected to production and dye decolorization study. Ligninolytic enzyme production was done by Submerged Fermentation (SmF). Various process parameters like different pH, temperature, carbon, nitrogen sources, and metal ions were investigated on Laccase (Lac), Lignin peroxidase (LiP) and Manganese peroxidizes (MnP) production in the fermentation process. The study revealed that the Lac, Lip and MnP highest activity was observed at pH 6.0, 5.5, and 7.2 respectively. Lac, Lip, and MnP showed highest activity at temperature 45°C, 40°C and 40°C respectively. Glucose as carbon source and modified PDB (Potato dextrose broth +2% saw dust + 1% yeast extract) as nitrogen source support maximum laccase activity. Starch as carbon source and modified PDB as nitrogen source enhanced the highest activity of Lignin peroxidase and Manganese...
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