Posted by admin on Jan 31, 2020 in |
Nanoparticles represent one of the alternatives in the treatment of cancer chemotherapy. In the present study, the prime objective was to formulate anti-cancer drug, bendamustine into polymeric chitosan nanocarrier system for its sustained release and passive targeting mechanism. Based on particle size, zeta potential and polydispersity index, F3 was selected as the optimized formulation. The SEM images revealed nanostructure with linear/rod shape enabling better internalization. The X-ray powder diffraction analysis clearly indicates reduction in crystallinity of bendamustine in nanoparticles. The nanoparticle formulation showed good results in terms of assayed drug content and encapsulation efficiency. The in-vitro permeation studies using egg membrane revealed that F3 formulation showed a sustained drug release for 28 h with an initial burst release within 1...
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Posted by admin on Jan 31, 2020 in |
Escherichia coli is the predominant isolated type of bacteria in urinary tract infections in children. Multidrug resistance of this kind of infection is associated with an increased risk of kidney injury and, therefore, an increase in morbidity and mortality. This report presents a case of a 6-year-old child with recurrent pyelonephritis with multidrug-resistant E. coli. She was followed, in a teaching hospital and was successfully treated with daily cephalexin prophylaxis for about four years as a result of the collaboration of healthcare providers. Continued teamwork between health care providers, especially collaboration between the treating pediatric nephrologist and the clinical pharmacist, yielded better decisions to overcome the multidrug-resistant bacteria over the course of the disease in such a vulnerable child patient. This case lends support for the use of suppression therapy in pediatric patients with severe recurrent bladder and renal infections as well as support for the patient-centered approach in achieving improved pharmacotherapy and patient...
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Posted by admin on Jan 31, 2020 in |
Bacteria have proved remarkably developing resistant to a known antibiotic; however, Medicinal plants have manifested notably useful for the control of bacterial infections. This study aimed to isolate and identify the multidrug-resistant bacteria from wound infection, then examine the antibacterial activity of different concentration of the ethanolic extracts of Cymbopogon proximus, Azadirachta indica, and Grewia senegalensis plants against it. One hundred specimens collected from wound infection, isolation and identification done according to standard methods. Antibiotics susceptibility test performed using the Kirby-Bauer disc diffusion method for: Cotrimoxazole (25 μg) Ciprofloxacin (5 μg), Gentamicin (10 μg), Imipenem (10 μg), Erythromycin (15 μg), Tetracycline (30 μg) Methacillin (5 μg), Ceftazidime (30 μg). 94 isolates showed bacterial growth, 40 (42.6%) isolates were Gram-positive bacteria (Staphylococcus aureus) and 54 sample Gram-negative bacteria; 15 (27.8%) Pseudomonas aeruginosa, 13 (24.1%) Proteus spp, 12 (22.2%) Escherichia coli, 10 (18.5%) Klebsiella pneumonia, 4 (7.4%) Citrobacter freundii. Ethanolic extracts from Sudanese medicinal plants namely Cymbopogon proximus, Azadirachta indica, and Grewia senegalensis, screened for their antimicrobial properties against isolated multidrug-resistant...
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Posted by admin on Jan 31, 2020 in |
Quercetin is a plant flavonol that is available from both daily diet and nutraceuticals. Various studies report that Quercetin alters the pharmacokinetics of various drugs by mechanisms like p-glycoprotein (p-gp) inhibition or other unknown mechanisms. The study was undertaken to evaluate the effect of Quercetin on the pharmacokinetics of Eletriptan. A single dose in-vivo pharmacokinetic study was carried out in rat models. In this study, rats were treated with Quercetin (10 mg/kg) and Eletriptan (2 mg/kg) orally and blood samples were collected at various time points such as 0 (predose), 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 6.0, 8.0, 12, 24 h post-treatment. Plasma concentration of Eletriptan was estimated using the HPLC method. AUC (0-24) of Eletriptan has significantly (p<0.01) increased in the Eletriptan and Quercetin combination group 1451.98 ± 93.78*** (ng/ml/h) when compared to AUC (0-24) Eletriptan alone treated group 883.94 ± 77.25 (ng/ml/h). AUC0-∞ of Eletriptan has significantly (***p<0.001) increased in the combination group (1543.32 ± 182.39*** (ng/ml/h).) in comparison to AUC0-∞ of Eletriptan of Eletriptan...
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Posted by admin on Jan 31, 2020 in |
Objective: In the present dissertation work, the aim was to prepare self-emulsifying drug delivery systems (SEDDS) of mirtazapine to improve its solubility with a view to enhance its oral bioavailability. Methods: The prepared SEDDS was the concentrate of the drug, oil-Capmule MCM EP, surfactant tween 80 and PEG 400 as a co-surfactant. The optimized microemulsion was converted into solid form by adsorption technique by using as Neusiline US2 solid carrier. The formulation was evaluated for various tests such as solubility, drug content, emulsification time, phase separation study, dispersibility test, droplet size analysis and PDI determination and zeta potential and in-vitro release study, and in-vitro permeation study. Results: The optimized formulation F5 showed drug release (96.97 ± 1.89), droplet size (153), Zeta potential (-30mv). All formulations of mirtazapine SEDDS were showed faster dissolution than plain drug, mean bioavailability of mirtazapine increase in respect to the plain drug. The F5 can be further used for the preparation of various solid SEDDS. In conclusion, self-emulsifying drug delivery system has become promising tool...
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