Posted by admin on Jan 31, 2020 in |
Pectin is a complex polysaccharide and has been used in food and pharmaceutical industries. The current study aimed to determine antioxidant and cytotoxic activities of pectin from peels of grape fruit (GP) and lemon (LP) by ferric reducing power (FRP) assay and brine shrimp lethality bioassay respectively. In addition, antioxidant and cytotoxic activities of GP and LP were compared with food-grade pectin (FGP). GP and LP exhibited positive results of antioxidant and cytotoxic activities. The percentage FRP of GP at 10 to 100 µg/ml was found to be higher as compared to FGP while LP showed closed values to that of FGP. The observed percentage mortality of shrimps at 10 to 1000 µg/ml by LP was found to be higher as compared to percentage mortality caused by FGP. Percentage mortality of shrimps by GP and FGP showed closed values. The LC50 of LP was found to be lower than that of FGP but close to the LC50 of standard drug etoposide. The LC50 of GP was closed to that...
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Posted by admin on Jan 31, 2020 in |
A novel copper (II) complex has been synthesized with Schiff base ligand obtained by the reaction of substituted carbohydrazone and thiosemicarbazide hydrochloride from the condensation reaction of ester and primary aromatic amine. The synthesized ligand and its copper (II) complex were characterized by various spectroscopic techniques like FT-IR, H1 NMR, UV-Visible, Fluorescence, powder XRD and Thermo-gravimetric analysis. Ligand and its copper complex were also screened for antioxidant and anticancer activities. In Cu (II) complex 1:2 copper to ligand molar ratio was obtained from analytical data. The molar conductance data confirm that complex is non- electrolytic in nature. Based on the electronic and magnetic data, a distorted octahedral geometry is ascribed for the Cu (II) complex. Ligand and its Cu (II) complex showed considerable anticancer activity against MCF-7 cell lines and more pronounced antioxidant activity in the presence of DPPH. Furthermore, molecular docking of ligand and its copper complex into the binding site of topoisomerase IIα was carried out using Auto Dock Vina software which demonstrated significant binding energies of...
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Posted by admin on Jan 31, 2020 in |
Background: Acute respiratory distress syndrome (ARDS) is a medical condition occurring in critically ill patients characterized by extensive inflammation in the lungs and associated with several complications. Therefore, the present study aimed to identify the common risk factors associated with ARDS in Hail Region, Northern Saudi Arabia. Methodology: This study investigated retrospectively 68 patients with ARDS clinical presentations during the period from January 2015 to January 2016 in King Khalid Hospital, Hail, Saudi Arabia. Results: Out of 68 patients with ARDS clinical presentations, ARDS was verified in 38/68 (55.9%). Out of 38 ARDS patients, 21/38(55.3%) were males and 17/38 (44.7%) of the 68 studied patients, pneumonia, trauma, H1N1 infection and fibrosis were identified in 50(73.5%), 3(4.4%), 13(19.1%) and 12 (17.6%), respectively. Out of the 38 ARDS patients, 29/38 (76.3%) died. Conclusion: ARDS is common in Hail Region and a common cause of patients to be admitted to specialized intensive care units. Inhalation injuries associated with pneumonia, H1N1 infection and fibrosis were an independent risk factor for ARDS. The mortality...
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Posted by admin on Jan 31, 2020 in |
Pituranthos chloranthus and Artemisia vulgaris L. are two of the most important aromatic and medicinal species from the Apiaceae and Asteraceae families, respectively. They are traditionally used in certain pathologies in which inflammatory processes are involved. The present study investigates the potential of aqueous extracts of Tunisian P. chloranthus and A. vulgaris as a natural alternative source of antioxidant and anti-inflammatory activities using in-vitro techniques. The antioxidant activities of aqueous extracts were evaluated through several assays: capacity for scavenging free radicals (ABTS, DPPH, hydroxyl, superoxide, nitric oxide); and total antioxidant capacity by ferric reducing power activity and inhibition of lipid peroxidation by thiobarbituric acid reactive species (TBARS) method. The anti-inflammatory activity was evaluated through the lipoxygenase (LOX) inhibitory activity. P. chloranthos aqueous extract presented higher concentration of total phenols than A. vulgaris extract, nevertheless higher capacity for scavenging ABTS, superoxide, hydroxyl, and NO free radicals. In the presence of liver homogenate, both extracts had poorer antioxidant activity than in the remaining lipid substrates. P. chloranthos extract had a higher...
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Posted by admin on Jan 31, 2020 in |
Mupirocin is a topical antibiotic which is very effective against staphylococci, streptococci and Methicillin-Resistant Staphylococcus aureus (MRSA) infection. Because of its high effectiveness against MRSA infection, it is frequently used in clinical practice for decolonization of MRSA. Due to the increased use of mupirocin, increased resistance rates have been reported. Essential oil is a natural antimicrobial agent which kills the bacteria without promoting the acquisition of resistance. Hence, the combination of mupirocin with essential oils would be an ideal solution for preventing mupirocin resistance. Therefore, in this study we have investigated the antibacterial effect of mupirocin in combination with 3 essential oils (cinnamon, eugenol, and eucalyptus). Zone of inhibition test using disk diffusion method and Minimum Inhibitory Concentration (MIC) test using broth dilution method was carried out to assess the antibacterial activity against S. aureus. In this study, we have checked the type of interaction (synergistic, antagonistic, indifference, additive effect). From the results, it was observed that all the essential oil showed potential synergistic antibacterial effect against S. aureus....
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