Posted by admin on Oct 31, 2019 in |
A novel starch was isolated from weed rice crop and its starch properties were compared with rice starch. The starch properties studied were physicochemical, pasting, thermal and X-ray diffraction. The amylose content and swelling power (g/g) of weed rice starch was 13.7% and 19.8 g/g, respectively. Light transmittance (%) of starch paste from weed rice was observed higher as compared to rice starches. Pasting properties (PV, TV, SB, and FV) of weed rice starch was within the range of those earlier reported for rice starches. The transition temperatures (To, Tp and Tc) and enthalpy of gelatinization (ΔHgel) were evaluated by using differential scanning calorimetry (DSC). The values of To, Tp and Tc were 68.86, 77.45 and 82.05 °C, respectively, for weed rice. ΔHgel value for weed rice starch was 3.80J/g which was significantly lower than that of rice starches (8.09-13.81J/g). X-ray diffractions behavior for both weed and conventional rice starches exhibited a typical A-type pattern which is normally reported for cereal starches. Weed rice starch was also studied for...
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Posted by admin on Oct 31, 2019 in |
Objective: The objective of the study was to evaluate the in-vivo anticancer and antioxidant activity of methanolic extract of leaves of Annona reticulata Linn. on EAC induced solid tumor. Methodology: Tumor cells (1 × 106 cells/mice/I.M.) were injected into the hind limb for solid tumor formation, and the treatment started from day 1 for 14 days. Group 1 served as a Normal control, Group 2 served as EAC control, whereas Group 3 served as a standard group (5-FU, 20 mg/kg/ip), & Group 4 & Group 5 served as test drug 100 & 200 mg/kg/po respectively. During the treatment, the different groups are checked with the parameters like Mean survival time, % increase in life span, Average body weight, Tumours size, on 15th day the blood was withdrawn for hematological parameters, SGOT, SGPT, ALP, and liver & tumor was isolated for histopathology studies, simultaneously antioxidant was carried out. Results and Conclusion: A significant increase in the life span and a decrease solid tumor volume were noted in the tumor-induced mice...
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Posted by admin on Oct 31, 2019 in |
Objective: To assess the reproductive toxicity of concoction of Andrographis paniculata in male Wistar albino rats. Methods: 18 male Wistar albino rats were divided into 3 groups with 6 animals in each group. Group 1 served as control and received distilled water. Group 2 and 3 received 0.5 ml of a concoction of Andrographis paniculata and Nilavembu kudineer (a concoction of 9 herbs) respectively for 30 days. Serum testosterone levels were measured at the baseline and at the end of the study. Animals were sacrificed at the end of the study, and histopathological examination of testes and sperm analysis were carried out. Results: There were no significant changes in the body weight and general behavior of the animals within the groups and between the groups. The differences noted in mean sperm count, as well as the qualitative characteristics such as progressive & non-progressive sperms and percentage of immotile sperms among the 3 groups, were not significant. Histopathology of testes did not show any difference between the control and treated...
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Posted by admin on Oct 31, 2019 in |
Objective: To evaluate the analgesic and anti-inflammatory effects of the methanolic extract of the Jatropha curcas (MEJC) belonging to the family Euphorbiaceae. Materials and Methods: Phytochemical screening was done by standard procedures. Acute toxicity studies were done by using female albino mice weighing 23-35 gm as per OECD 425 guidelines. In the hot plate models for analgesic activity, the oral administration of J. curcas extract at the three different doses of MEJC like (100, 200, 400 mg/kg) and the reference drug diclofenac sodium (25 mg/kg) were administered. The control group was taken using normal saline 0.9% NaCl solution. While in the carrageenan-induced paw edema models, the same dosage regimen as per the analgesic activity were followed but the standard drug dose of aspirin is 150 mg/kg. Results: Phytochemical screening revealed the presence of flavonoids, steroids, alkaloids, tannins, carbohydrates, cardiac glycosides. The extract was found to be non-toxic up to the dose of 2000 mg/kg after the acute toxicity test. In analgesic all the three doses of MEJC i.e. 100mg/kg...
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Posted by admin on Oct 31, 2019 in |
The present investigation deals with fast disintegrating tablets of the model drug (Telmisartan) and to determine the influence of the excipients on physical properties of tablets. Employing a Box Behnken design, concentration of co-processed superdisintegrants (Crosspovidone: sodium starch glycolate) (X1), the concentration of meglumine (X2) and concentration of sodium lauryl sulfate (X3), selected as independent variables whereas disintegration time (Y1) selected as the dependent variable. All formulations were evaluated for pre-compression and post-compression parameters. Mathematical equations and response surface plots were used to relate the dependent and independent variables. The regression equation generated for disintegration time (DT) of Telmisartan tablets was Y1=30.25-1.6887A-1.2175B +2.7437C +0.1675AB +2.02AC+3.007BC-2.6752A2-3.62B2+ 0.0425C2. The statistical validity of the polynomial was established, and optimized formulation factors were selected by feasibility and grid search. Validation of the optimization study with 13 confirmatory runs indicated a high degree of prognostic ability of response surface...
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