Posted by admin on Nov 30, 2019 in |
The current study deals with anti-diabetic and pancreatic protective effects of Flemengia strobilifera extracts in a high-fat diet (HFD) and streptozotocin (STZ) induced type 2 diabetes model. Toluene extracts were orally administered at the dose of 10, 30 and 100 mg/kg and metformin was used as a standard anti-diabetic drug at 10 mg/kg dose orally. Blood glucose, lipid profiles, pancreatic oxidative stress parameters and oral glucose tolerance test (OGTT) were performed. Treatment with extracts resulted in a significant decrease in diabetes incidence with a marked reduction in the blood glucose levels dose dependent and time dependent. Glucose tolerance was greatly improved after treatment with plant extracts with high dose group producing effects similar to standard drug-mediated beneficial effects. Histopathological studies also indicated pancreatic beta-cell protective effects of Flemengia strobilifera extracts with increased beta-cell number and size. Our results demonstrate that Flemengia strobilifera can be a possible remedy to treat type 2 diabetes and associated...
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Posted by admin on Nov 30, 2019 in |
Background: Hypertension is associated with the flow of blood under high pressures, and is a risk factor for coronary heart disease. Methodology: We designed a prospective observational study that included 280 participants to investigate the effect of hypertension on the health-related quality of life (HRQOL) for hypertensive patients in the eastern province of KSA. To measure HRQOL, this study used EQ-5D-5L which consists of five dimensions that are further divided into five levels of severity. Results: Among the normotensive participants, 77%, 96%, 66%, 38%, and 44% were agreed as having no problem in terms of self-care, anxiety or depression, usual activities, mobility, and pain or discomfort respectively; whereas among the hypertensive participants, these were 36%, 79%, 20%, 21%, and 31% respectively. Conclusion: We concluded that health-related quality for hypertensive patients is significantly affected by HTN. Therefore, great attention must be paid to enhance their quality of life to avoid any future...
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Posted by admin on Nov 30, 2019 in |
The main objective of the study was to formulate tablets of Candesartan cilexetil using the crystal agglomerates for the enhancement in flow properties and solubility. The crystal agglomerates were prepared by polymer enriched bridging liquid (PEBL) technique. The process requires three solvent systems, the good solvent for the drug, the bad solvent and the bridging liquid. The hydrophilic polymer PVP K30 was incorporated in the bridging liquid. The addition of hydrophilic polymer increased the hydrophilicity and wettability of Candesartan cilexetil. The saturation solubility analysis, percentage yield, drug content, micromeritic properties, FTIR, DSC, XRD, SEM were carried out for the evaluation of crystal agglomerates. The tablets were prepared by direct compression using the formulated crystal agglomerates and were subjected to various in-vitro evaluations. The crystal agglomerates prepared by the PEBL technique showed 25 folds enhancement in the solubility. The FTIR analysis revealed the absence of incompatibility. The DSC analysis and XRD pattern showed a reduction in crystallinity. The SEM analysis revealed the porous and sphericity of the agglomerates. The tablets...
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Posted by admin on Nov 30, 2019 in |
The liver is a vital organ of the human body. It is responsible for protecting the body from harmful substances and the maintenance of good health. In last few years, various types of liver disorders, such as drug-induced liver disease, hepatomegaly, fatty liver disease, liver cirrhosis, autoimmune hepatitis, chronic viral hepatitis, autoimmune hepatitis, etc. are become a people’s health problem. Recently numbers of ayurvedic polyherbal and herbomineral formulations are available commercially and physician preferring these formulations for the treatment and management of various liver diseases as modern medical treatment available for liver diseases produces systematic toxicity. In this study a herbomineral formulation “Arka Lavana” was prepared in the laboratory by traditional method using fresh leaves of arka (Calotropis procera) and saindhav lavana and experimentally evaluated against hepatotoxicity induced by dexamethasone and alcohol. It is traditionally used in the treatment of liver and spleen anomalies and ascites etc. The study was evaluated by using 60 mg/kg 90 mg/kg and 120 mg/kg of arka lavana and standard silymarin at a dose...
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Posted by admin on Nov 30, 2019 in |
The geometrical structure and conformational energy stability of vinyl halides CH2=CH–X (X = F, Cl, and Br) were examined by using Density Functional Theory calculations (B3LYP method in combination with 6-311G* basis sets). The values of HOMO-LUMO gap (DE) for vinyl halides (fluoride, chloride and bromide) were 7.68 (eV), 7.10 (eV) and 6.55 (eV) respectively. The calculated geometrical parameters were in good agreement with the previously observed results. Both HOMO-LUMO gap and geometrical parameters were found to account for the stability of the molecules. Electron distribution in HOMO-LUMO Frontier molecular orbitals was investigated to show the charge transfer within the molecules. The atomic charges and molecular electrostatic potential were interpreted together to demonstrate the electrophilic -nucleophilic reactivity. The vibrational frequencies were computed, the comparison between the three halides revealed that vinyl chloride and vinyl bromide have strong C-X stretching vibrations bands, but for vinyl fluoride the bands are weaker, the intensity characterization increasing from F to Br...
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