Posted by admin on Sep 30, 2019 in |
The objective of the present study was to formulate and evaluate a gastro-retentive stomach specific novel floating in-situ gelling system of curcumin for potentially treating gastric ulcer, associated with Helicobacter pylori. The in-situ gel of curcumin was prepared by dissolving different concentrations of gelling polymer like sodium alginate in distilled water at 60 ºC. After cooling to 40 ºC, required quantities of sodium citrate and calcium carbonate were dispersed in it with continuous stirring followed by the addition of curcumin and sorbitol. Identification of drug was confirmed by DSC (melting point study), FTIR (functional groups study), and UV spectrophotometric analysis. Compatibility between drug and polymer were confirmed by DSC and FTIR studies. The micromeritic properties of curcumin were done, and all formulations showed pH in the range of 6.6 to 7.4, floating lag time was less than 1 min, duration of floating was more than 24 h for all the prepared formulations. Gelling capacity, gel strength, viscosity, and water uptake by the gel increased with the increase in sodium...
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Posted by admin on Sep 30, 2019 in |
The objective of the present study was to develop and validate a novel RP-HPLC method for the determination of Dasatinib in the pharmaceutical dosage form. Chromatographic separation was conducted on agilent technologies-1260 series with the G1311C quaternary pump, Thermo Scientific C18 column (4.6 mm i.d. × 250 mm, 5 µm particle size) and equipped with photodiode array detector G1315D. The mobile phase consisted of methanol and acetonitrile mixed in the ratio of 50:50 v/v, was used at a flow rate of 1 ml/min, and the detection wavelength was set at 323 nm. The retention time for Dasatinib was found to be 4.073 min. The calibration was linear (r2 = 0.999) in the concentration range of 2-10 µg/ml. The limit of detection and the limit of quantitation were found to be 0.5263 μg/ml and 1.5948 µg/ml, respectively. Recovery of Dasatinib in tablet formulation was observed in the range of 98.09-99.57%. Percentage assay of Dasatinib (Dasanat) was found to be 99.45% w/w. Thus the novel proposed method for Dasatinib was found...
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Posted by admin on Sep 30, 2019 in |
The elected work reports for the first time successfully synthesized nanosilver from the aqueous leaf extract of the Carchorus hirsutus plant. Because the phytochemicals within the leaf extract were creditworthy for the reduction of silver ions as the active nanosilver particles, in addition to this, they act as the capping agents who had been environed at the surface of the particles. UV-Vis spectroscopy oversaw the establishment of nanosilver as an appropriate peak detected at 412 nm of surface plasmon resonance has affirmed the colloidal nanosilver. The peaks of Fourier Transform Infrared Spectroscopy had proved to be phytochemicals responsible for the reduction of nanosilver. The crystalline structure and average diameter found to be 29 nm of the phytosynthesized nanosilver particles were found out using X-ray diffraction studies. The Scanning Electron Microscopy images were rendered the aggregated, semi-spherical to spherical silver nanocrystals. The elemental signals of energy dispersive X-ray spectrum substantiate the presence of silver detail as silver weight % is 86.84 and atomic % is 68.45. The atomic force microscope...
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Posted by admin on Sep 30, 2019 in |
The aim of the present study was to develop and evaluate thermo-sensitive in-situ implant forming injectable organogel systems of diclofenac sodium for prolonged drug effects. The formulations were prepared by separately dissolving fatty acids such as arachidic acid, stearic acid or palmitic acid in injectable soybean oil. The organogels were evaluated for physicochemical parameters as well as for in-vitro, ex-vivo release and in-vivo fluorescence imaging. All the formulations showed gelation temperature and gelation time in the range of 36.6 to 37.1 ºC and 38 to 61 sec respectively. The pH of the formulation was found to be in the range of 6.67 to 7.14. All the formulations appeared opaque, off white and free from aggregates during the study and passed the test for syringeability and injectability. The drug content of the formulations was found in the range of 89.5 to 93.5 percent. The in-vitro drug release study showed that the release followed zero-order kinetics and ex-vivo drug release was slower when compared to in-vitro drug release. In-vivo fluorescence imaging...
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Posted by admin on Sep 30, 2019 in |
An enteric coating is a polymer barrier applied to oral tablets; it prevents dissolution and disintegration of tablet in the gastric environment. Some drugs like aspirin that have an irritant effect on the GI Track after administration, can be prepared as enteric-coated tablet. Aspirin is used to reduce fever and to relieve pain from various conditions. By coating aspirin tablet with polymer it prevents the stomach bleeding. Novel biodegradable epoxy resins having special properties like dissolution in alkaline solution but remain intact in acidic solutions. It is biodegradable, biocompatible, made from 100% bio-based content, non-toxic in nature. Owing to these above advantages we have used bio epoxy resin for coating on aspirin table and tested its performance at various conditions. Coated tablets are found resistant to gastric pH and percentage drug release after 90 min was found 48%. The performance data was compared with various commercial brands available in the market. Coating aspirin tablet with bio epoxy resin is a safe...
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