Posted by admin on Jan 31, 2020 in |
The global burden of CVD is rising due to its increasing prevalence in lower- and middle-income countries where 80% of all global CVD-related deaths occur. Common significant risk factors for dyslipidemia included obesity, diabetes, and dysglycemia. The present study was aimed to investigate the potential antihyperlipidemic activity of ethanolic leaf extract of Bauhinia acuminata in atherogenic diet-induced rats. Preliminary phytochemical screening showed the presence of flavonoids, alkaloids, steroids, terpenoids. Acute toxicity study was performed on the rats using OECD Guideline no. 423 and the maximum safe dose was found to be 5000 mg/kg. Animals were grouped into normal control (Group-I), disease control (Group-II), standard group (Group-III) received Standard drug Atorvastatin 10 mg/kg, and test group (Group-IV) received ethanolic extract of the plant with doses 200 mg/kg and 400 mg/kg. The study was conducted for 30 days and hyperlipidemia induced using atherogenic diet. Statistical analysis was performed using Graph Pad Prism and the values are expressed as mean ± SD values. Bodyweight changes were observed every day upon Induction of...
Read More
Posted by admin on Jan 31, 2020 in |
Niosome is one of the synthetic nanoparticles which often is used for drug delivery and cosmetic industry. The aim of this study was to prepare niosomes encapsulated with KT2 and RT2. KT2 and RT2 are antimicrobial and anticancer peptides derived from crocodile leukocyte extract. Niosomes encapsulated with KT2 and RT2 were prepared by thin-film hydration technique, and peptide encapsulation efficiency was evaluated. Niosome particle size, size distribution, and surface morphology were also studied. The results show that KT2 and RT2 were successfully loaded in the formulations with encapsulation efficiencies of 70.9 ± 0.9% and 59.6 ± 3.4%, respectively. The mean particle size and zeta potential of KT2 and RT2 encapsulated niosomes were 9.3 ± 1.13 µm and – 57.39 ± 2.53 mV and 9.1 ± 0.03 µm and – 50.91 ± 2.28 mV, respectively. Niosomes had spherical shapes with rough surfaces. Niosomes coated with hydroxypropyl methylcellulose phthalate (HPMCP) were evaluated for pH stability. At pH 1.2 and 4.5, the peptide-encapsulated niosomes were stable. In conclusion, these peptide-encapsulated niosomes have...
Read More
Posted by admin on Jan 31, 2020 in |
Objective: Lepidium sativum (Garden cress) is traditionally an important plant with a wide range of activities from the ages. Ample literature about its biological activities, motivate us to evaluate the total flavonoids content and to screen the nootropic activity in mice. Methods: Ethanolic extract was prepared from the seeds of Lepidium sativum using ethanol (70% v/v) and total flavonoids content was estimated by using Zhishen method. The ethanolic extract was screened for its acute toxicity and nootropic activity by elevated plus maze (EPM) and morris water maze (MWM) test in mice. Results: The results showed that the ethanolic seed extract of the plant is having a good amount of flavonoids (17.54 ± 47 of gram equivalence of rutin at 510 nm) and also exhibited significant increase in memory and learning abilities. Conclusion: To conclude, the flavonoids that are present in the ethanolic extract may be responsible for the exhibited activity and it is regarded as safe to administer to the animals. Moreover, further studies are necessary to explore its...
Read More
Posted by admin on Jan 31, 2020 in |
Fossil fuels are significantly depleted nowadays due to excess utilization. Therefore, it is always better to find alternatives to produce eco-friendly fuels. This paper deals with the production of biodiesel from agro-industrial waste such as young coconut husk, custard apple seeds and broiler chicken skin. Lipids were isolated from the substrates using the modified Bligh and Dyer method and transesterification was conducted to the isolated lipids in an inert condition to produce biodiesel. Obtained biodiesel was characterized by Gas Chromatography-Mass Spectroscopy (GC-MS) and confirmation of esters was done using Fourier Transform Infrared (FTIR). This study encourages the production of biodiesel from waste plant and animal...
Read More
Posted by admin on Jan 31, 2020 in |
The drug Parpataka is used particularly for the treatment of fevers, indigestion, biliousness, burning of the body, tired feeling, giddiness, urinary discharges, vomiting, thirst, enriches the blood and works good in leprosy. The present study is intended to authenticate and validate the species of Peristrophe paniculata (Forssk.) Brummitt, which is one of the sources of the Parpataka drug used in Ayurvedic and Siddha systems. The objective of the present work was to assess and established the various pharmacognostical properties like; macroscopical, micro-scopical (cell structure and their arrangement), physicochemical (including different ash values, loss on drying and extractive values), fluorescence and preliminary phytochemical profiles of the leaf, stem and roots of the plant. Qualitative tests for various functional groups were also carried out. The pharmacognostical screening of Peristrophe paniculata on different standardization parameters may prove to be very useful for the correct identification of the genuine drug and also to determine the quality and purity of the plant material to be used in different Ayurvedic...
Read More
