Posted by admin on Nov 30, 2019 in |
The present exploration is an attempt to an ethnobotanical study was conducted in Eastern Ghats of Tamil Nadu, for the investigation of a medicinal plant used to treat several diseases by the local health healers by Gedamalai Tribes, Namakkal District. Data were collected during March 2015-January 2016. Quantitative analysis, including the informant consensus factor and use-value was performed to evaluate the medicinal plants. A total of 40% of women reported high affiliation with herbal remedies for gynecological problems, while others attribute was also positive for medicinal plants. A total of 27 species belonging to 23 genera and 19 families were recorded. This result also proved that the plant is used either the whole plant or various parts like leaves, stem, root, flower, seed, etc. The plant parts are used in the form of decoction, juice, paste, and powder. These plants were used to treat gynecological disorders. The botanical names, families, vernacular names were also given along with medicinal...
Read More
Posted by admin on Nov 30, 2019 in |
Alzheimer’s disease (AD) is a disorder of the central nervous system with progressive neurodegeneration, cognition, and memory loss. A major molecular hallmark of the disorder includes extracellular deposition of the Amyloid beta-peptide (Aβ) in senile plaques, the appearance of intracellular neurofibrillary tangles. The Aβ peptide is produced by sequential cleavage of the Amyloid precursor protein (APP) by α, β, and γ-secretase. The secretase β and γ generate a number of isoforms of peptides containing 36-43 amino acid residues in length. The mainly universal isoforms are Aβ(1-40) and Aβ(1-42). Aβ(1-42) C-terminal domain (29-42 amino acid residues) adopts β conformation, and the N-terminal domain (10-24 amino acid residues) facilitates a dynamic equilibrium between α- helix and β-strand. Thus Aβ polymerization requires unfolding of the native α-helical structure of Aβ. Stabilization of the Aβ central α- helix is an efficient step to foil the Aβ polymerization. Here we report test compounds which to bind and stabilize the 11-30 amino acid regions of Aβ(1-42) in α-helical conformation. On docking, the ligands with Aβ...
Read More
Posted by admin on Nov 30, 2019 in |
Three novel metal complexes of 2-aminobenzonitrile (ABN) and octanoate ion (OC) with Mn2+, Co2+, and Ni2+ have been prepared by using microwave irradiation. The DNA-binding properties of the free ligand 2-aminobenzonitrile and its Mn2+, Co2+ and Ni2+ complexes have been investigated by fluorescence measurements. The results suggest that ABN, Mn2+, Co2+ and Ni2+ complexes both bind to DNA via an intercalative binding mode and the affinity for DNA is more strong in case of Mn2+, Co2+, and Ni2+ complexes when compared with ABN. The intrinsic binding constants (Kb) of the Mn2+, Co2+ and Ni2+ complexes and ligand with DNA were 2.75 × 104 M−1, 3.08 × 104 M−1, 3.80 × 104 M−1 and 1.96 × 104 M−1, respectively. Ni2+ complex is strongly bound to DNA compared to other complexes and the ligand. Furthermore, the free radical scavenging activity of the free ligand and their complexes has been determined by measuring their interaction with the stable free radical DPPH. The complexes have larger antioxidant activity as compared to the...
Read More
Posted by admin on Nov 30, 2019 in |
The current study deals with anti-diabetic and pancreatic protective effects of Flemengia strobilifera extracts in a high-fat diet (HFD) and streptozotocin (STZ) induced type 2 diabetes model. Toluene extracts were orally administered at the dose of 10, 30 and 100 mg/kg and metformin was used as a standard anti-diabetic drug at 10 mg/kg dose orally. Blood glucose, lipid profiles, pancreatic oxidative stress parameters and oral glucose tolerance test (OGTT) were performed. Treatment with extracts resulted in a significant decrease in diabetes incidence with a marked reduction in the blood glucose levels dose dependent and time dependent. Glucose tolerance was greatly improved after treatment with plant extracts with high dose group producing effects similar to standard drug-mediated beneficial effects. Histopathological studies also indicated pancreatic beta-cell protective effects of Flemengia strobilifera extracts with increased beta-cell number and size. Our results demonstrate that Flemengia strobilifera can be a possible remedy to treat type 2 diabetes and associated...
Read More
Posted by admin on Nov 30, 2019 in |
Background: Hypertension is associated with the flow of blood under high pressures, and is a risk factor for coronary heart disease. Methodology: We designed a prospective observational study that included 280 participants to investigate the effect of hypertension on the health-related quality of life (HRQOL) for hypertensive patients in the eastern province of KSA. To measure HRQOL, this study used EQ-5D-5L which consists of five dimensions that are further divided into five levels of severity. Results: Among the normotensive participants, 77%, 96%, 66%, 38%, and 44% were agreed as having no problem in terms of self-care, anxiety or depression, usual activities, mobility, and pain or discomfort respectively; whereas among the hypertensive participants, these were 36%, 79%, 20%, 21%, and 31% respectively. Conclusion: We concluded that health-related quality for hypertensive patients is significantly affected by HTN. Therefore, great attention must be paid to enhance their quality of life to avoid any future...
Read More
