Posted by admin on Oct 31, 2019 in |
The main objective of the study was to enhance the dissolution of fenofibrate (BCS class II), poorly soluble drug. To improve the solubility of the drug, solid dispersions were prepared by dropping method with PEG 4000 and PEG 6000 in the ratios of 1:1 and 1:2. The formulations were filled into capsules and evaluated for solubility, assay, FTIR, X-ray diffractions, DSC, and in-vitro dissolution. The optimized formulation was compared with the marketed formulation. The optimized formulation D4 (containing PEG 6000 (1:2) by dropping method) showed maximum solubility 0.678 ± 0.07 mg/ml when compared to pure drug (0.018 mg/ml), assay, 98.14 ± 12% and practical percentage yield 95.25 ± 0.17%. In-vitro dissolution studies of the prepared solid dispersions showed release in 60 min whereas D4 formulation released 99.10 ± 0.18% in 30 min when compared to pure drug 27.38 ± 0.10% in 60 min, and a marketed capsule containing micronized fenofibrate (Lipicard) 93.91 ± 0.12% in 30 min. FTIR studies confirmed that there is no interaction between the drug and...
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Posted by admin on Oct 31, 2019 in |
Objectives: To retrospectively determine the prescription pattern of antiepileptic drugs (AEDs), hematobiochemical changes, and associated adverse effects. Methodology: A retrospective observational study was conducted at the Department of Neurology, King Fahad Hospital of the University, Khobar, KSA. Data Collection was through Electronic Health Record. A designed validated form to record demographic characteristics, hematological-biochemical parameters and adverse effects were utilized. Results: 115 patients were recruited. 54 (44%) were female and 64 (56%) were male. Carbamazepine; CBZ (n = 47; 40.9%) and Valproic acid; VPA (n = 32; 27.8%) were the most frequently prescribed antiepileptic drugs (AEDs). While CBZ + VPA (n = 21, 18.3%) was the most frequently prescribed combination. Generalized seizures were more frequently diagnosed (n = 80, 70%) compared to partial seizures (n = 22, 19%). The hematological abnormalities manifested as reduction in levels of Hemoglobulin (Hg), Hematocrit, Mean corpuscular volume (MCV), Mean corpuscular hemoglobin (MCH) with all AEDs, while CBZ treatment was additionally associated with reduction in Mean corpuscular hemoglobin concentration (MCHC). The combination of CBZ +...
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Posted by admin on Oct 31, 2019 in |
Diabetes mellitus is a lasting metabolic disability regarding enhance etiology and permanent degenerating complications. Sexual abnormalities (Hypogonadism, infertility, etc.) are outfit a two of the discombobulate ingenious stringency of diabetes mellitus. Different hypoglycemic agents are used to control diabetes mellitus, but very few formulations are available to treat secondary complications. Results of the present study establish the anti-diabetic properties of Camellia sinensis and its impact on the male reproductive systems of the streptozotocin-induced diabetic male...
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Posted by admin on Oct 31, 2019 in |
Quality by Design (QbD) has become an important concept for the pharmaceutical industry, and ICH recommends this concept through the Guideline Q8 (R2) wherein if the method is proved to be rugged and robust within the limits of a Design Space then approval may be requested for such a Design Space, and the method does not need redevelopment, revalidation, and reapproval during transfers, thereby saving significant time and resources. In this study, the QbD approach was used to develop a reverse-phase–high-performance liquid chromatography (RP–HPLC) method that could be applied for the estimation of several antibacterial agents of the fluoroquinolone group. The method was applied to five selected fluoroquinolones, namely, ciprofloxacin, levofloxacin, norfloxacin, moxifloxacin, and ofloxacin. The method developed used C18 column of make Phenomenex (250 mm × 4.6 mm, 5 μm) with mobile phase comprising of methanol and phosphate buffer (pH 3.0) in the proportion 70:30 at a flow rate of 1.25 ml/min and detection was carried out using a PDA detector at 294 nm. The method while being...
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Posted by admin on Oct 31, 2019 in |
A novel coordination complex of 2-aminobenzonitrile (ABN) and octanoate ion (OC) with Cu(II) metal ion has been prepared by using microwave irradiation. The molecular formula and the geometry of the complex have been deduced from elemental analysis, molar conductance, magnetic moment, electronic spectra, FT- IR spectra, cyclic voltammetry, thermal analysis and EPR spectra. The molar conductance value indicates that the complex is non-electrolyte (1:0) type. The electronic spectrum and the magnetic moment indicate the geometry of the complex is octahedral. FT-IR spectra show that 2-aminobenzonitrile is coordinated to the metal ion in a bidentate and octanoate ion in a monodentate manner. The metal-ligand covalency of Cu(II) complex has been arrived at from EPR spectrum. The antimicrobial activities of ligands and their Cu(II) complex were studied against the microorganisms, viz., staphylococcus aureus, streptococcus, Klebsiella, pseudomonas aeruginosa, salmonella typhi, Enterobacter, E. coli, C. albicans, Aspergillus flavus and Aspergillus niger by agar – well diffusion method. The complex shows potential activity against the bacteria and fungi as compared to the free ligands....
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