Posted by admin on Jul 31, 2019 in |
Objective: Oecophylla smaradina (Formicidae) is an ant evaluated for its variety of medicinal uses. The objective of this study to evaluate the anti-ulcer activity using albino rats. Methods: The albino rats of either sex were divided into four groups. Ethanolic extract of Oecophylla smaradina (EEOS) was tested in the dose of 200 and 400 mg/kg p.o. respectively against by pylorus ligation induced ulcer models in albino rats. Results: Both the concentration (200 and 400 mg/kg p.o.) of extract have provided significant activity but EEOS 200 mg/kg, p.o, extracts were less effective when compared to EEOS 400 mg/kg, p.o. The antiulcer activity was accessed by evaluate the ulcer index in the test and standard drug treated group and also estimated the gastric volume, total acid, and free acid in the pylorus-ligated rats. Conclusion: The present study was revealed that ethanolic extract of Oecophylla smaradina have antiulcer...
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Posted by admin on Jul 31, 2019 in |
Objectives: The objective of this research was dose reduction and toxicity reduction. Dose reduction: various anti-cancer drugs are very costly, and their high dose increases cost. If bioavailability is enhanced, the dose shall be reduced thereby; the cost will also decrease. Dose reduction will also reduce toxicity, and the preparation will become more tolerable. Method: In this study, the nanoparticles were developed by using a modified method with the drug cisplatin, which was later evaluated for stability, toxicity, and therapeutic efficacy using various in-vitro and in-vivo techniques like SRB assay. Results: The resulting dosage form found to be more affected and less toxic than the marketed preparation of drug cisplatin, which is i.v. injection. As cisplatin is a platinum compound and has the biggest drawback of the toxic side effects, which is making the chemotherapy less acceptable but with the preparation of nanoparticles side effects were minimized without harming the therapeutic efficacy. Anti-cancer agents have several adverse side effects and high levels of toxicity, e.g., Hair loss due to...
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Posted by admin on Jul 31, 2019 in |
Boerhavia diffusa is a species of flowering plant in the four o’clock family, Boerhavia belongs to family Nyctaginaceae the plant holds the tremendous potential of medicinal value and has been traditionally used in various ailments like syphilis, leukoderma, blood disorders to name a few. The present study focuses on the GC-MS analysis of extracts of all the plant parts of B. diffusa which revealed the presence of certain bioactive compounds like kaempferol, luteolin, quercetin and so forth. A total of about 20 bioactive compounds were identified. In Boerhavia diffusa in all plant parts roots, stems and leaves kaempferol is observed maximum. Total amount of flavonoids was maximum in leaves and minimum in stem. Antimicrobial activity of the extracts was assayed against pathogenic bacteria and fungi. In B. diffusa, flavonoids extracted from leaf were highly active against F. oxysporium, against bacterial strains flavonoids from leaves were highly active and showed maximum activity against E. coli. The study thus infers that the presence of bioactive components may be the principle behind the...
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Posted by admin on Jul 31, 2019 in |
The genus Euphorbia has about 2000 members making it one of the largest ones among the flowering plants. Euphorbia helioscopia L. As the chemical composition of the essential oil from Euphorbia helioscopia developed in Egypt has not yet been explored, along these lines the present to extricate the essential oil and investigate the oil chemical composition and antimicrobial activity. Essential oil from the whole inflorescence of the flowering plant, Euphorbia helioscopia Linn. was extracted by hydrodistillation method. The chemical composition of the obtained volatile oil was investigated by GC-MS. The major components include thymol (48.36%), Caryophyllene (23.57%), carvacrol (6.70%), caffeic acid (6.48%) and caryophyllene oxide (5.58). Minor components as translongipinocarveol (2.77%) and DL-malic acid (1.9%). Screening antimicrobial activity of the isolated volatile oil against four bacteria showed that it was active only against Bacillus subtilis with an inhibition zone of 11 mm ± 0.25 and MIC value 17 mg /ml. Gentamycin was utilized as a positive antibacterial control. The data of this study might be considered as the first...
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Posted by admin on Jul 31, 2019 in |
One of the proposed groupings of the fluoroquinolones describes the excellent broad-spectrum activity forms an invaluable part of the present anti-infective armory of the clinicians. The fluoroquinolones are most significant weapons can be credited for saving more human lives than any other area of medicinal therapy. In this current research segment, the novel C-3 substituted fluoroquinolone scaffolds were designed, synthesized and elucidated by IR, H1NMR, and MS spectral data. The clinically banned drug gatifloxacin is acting as starting material used to obtain targeted compounds. The proposed scheme comprised of main cyclization by using phosphorous oxychloride, thiosemicarbazide, gatifloxacin. The former compounds were undergoing diazotization reaction followed by a coupling reaction with various tertiary amines. Further, all seven 3- substituted gatifloxacin derivatives (PGI-PGVII) were screened for antimicrobial and hypoglycemic activity. In the novel series of compounds PG III, PG IV, PG V exhibited good antimicrobial activity by inhibition of DNA gyrase enzyme whereas PG I, PG III, PG VI, PG VII were found to be the most active compounds with hypoglycemic...
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