Posted by admin on Sep 30, 2019 in |
The aim of the present study was to develop and evaluate thermo-sensitive in-situ implant forming injectable organogel systems of diclofenac sodium for prolonged drug effects. The formulations were prepared by separately dissolving fatty acids such as arachidic acid, stearic acid or palmitic acid in injectable soybean oil. The organogels were evaluated for physicochemical parameters as well as for in-vitro, ex-vivo release and in-vivo fluorescence imaging. All the formulations showed gelation temperature and gelation time in the range of 36.6 to 37.1 ºC and 38 to 61 sec respectively. The pH of the formulation was found to be in the range of 6.67 to 7.14. All the formulations appeared opaque, off white and free from aggregates during the study and passed the test for syringeability and injectability. The drug content of the formulations was found in the range of 89.5 to 93.5 percent. The in-vitro drug release study showed that the release followed zero-order kinetics and ex-vivo drug release was slower when compared to in-vitro drug release. In-vivo fluorescence imaging...
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Posted by admin on Sep 30, 2019 in |
An enteric coating is a polymer barrier applied to oral tablets; it prevents dissolution and disintegration of tablet in the gastric environment. Some drugs like aspirin that have an irritant effect on the GI Track after administration, can be prepared as enteric-coated tablet. Aspirin is used to reduce fever and to relieve pain from various conditions. By coating aspirin tablet with polymer it prevents the stomach bleeding. Novel biodegradable epoxy resins having special properties like dissolution in alkaline solution but remain intact in acidic solutions. It is biodegradable, biocompatible, made from 100% bio-based content, non-toxic in nature. Owing to these above advantages we have used bio epoxy resin for coating on aspirin table and tested its performance at various conditions. Coated tablets are found resistant to gastric pH and percentage drug release after 90 min was found 48%. The performance data was compared with various commercial brands available in the market. Coating aspirin tablet with bio epoxy resin is a safe...
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Posted by admin on Sep 30, 2019 in |
In ancient literature plant Alstonia scholaris (Apocynaceae) has been considered medicinally important in the treatment of various ailments. Extracts of this plant have shown wide spectra of pharmacological activities like anti-cancer, hepatoprotective, anti-inflammatory, anti-diabetic, etc. These activities can be attributed to the depositories of various phytoconstituents like alkaloids, flavonoids, phenols, triterpenoids, saponins, etc. present in it. Thus, a simple and precise HPTLC method has been developed for identification and quantification of a pentacyclic triterpenoid- lupeol in the leaves of Alstonia scholaris. The developed method was validated following ICH guidelines concerning linearity, range, specificity, precision, accuracy, LOD, and LOQ. After derivatization, the optimized mobile phase Toluene: Ethyl acetate: Formic acid (7:2:1 v/v/v) exhibited good resolution of bands at 580 nm. The Rf value of lupeol was found to be 0.63 and amount quantified in ethanol and chloroform extracts of leaves was 0.31 and 0.35% w/w respectively. The calibration curve of lupeol was linear between 200-1000 ng/band with correlation coefficient 0.9990. LOD and LOQ were 55 and 166.69 ng/band respectively. Recovery...
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Posted by admin on Sep 30, 2019 in |
Rivaroxaban is utilized as a direct factor Xa inhibitor for the prevention and remedy of thromboembolic disorders. This study aimed to evaluate a generic version of rivaroxaban 10 mg tablet. Considering previous reports of safety and tolerability of a single dose (1.25-80 mg) of rivaroxaban, this study used a randomized, single-dose two-way crossover of rivaroxaban in 28 healthy volunteers, with a washout period of seven days. Analyses of blood samples were performed by a validated ultra-high performance liquid chromatography coupled with tandem mass spectrometry. An YMC-Pack ODS-AQ reversed-phase column with the mobile phase of acetonitrile and 10 mM ammonium acetate pH = 3 (70:30, v/v) at a flow rate of 0.3 mL.min-1 under isocratic elution was selected for the analysis. A range of 2.5-600 ng.mL-1 was obtained for the calibration curve. Pharmacokinetic parameters were calculated for the bioequivalence assessment. The results showed that two formulations have similar pharmacokinetics. The 90% confidence interval of the mean ratios of the test versus reference formulation of Ln transformed AUC0-30 (82.0-98.0), AUC0-inf (81.3-105.2),...
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Posted by admin on Sep 30, 2019 in |
Peptic Ulcer Disease (PUD) is one of the most prevalent pathogenic conditions which affects around 5-10% of the global population. Helicobacter pylori infection and the use of Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are two of the most common etiological causes in the PUD pathogenesis. First line treatment for PUD involves use of drugs which cause acid suppression or target against the eradication of Helicobacter pylori infection. Ulceration generally occurs due to the disturbance of the normal equilibrium caused by either enhanced aggression or diminished mucosal resistance. Peptic ulcer disease (PUD) may also occur as a result of the regular usage of certain drugs, irregular food habits, stress, alcohol consumption, and so forth. Recent years have shown a significant increase in the consumption of NSAIDs, despite their harmful side effects. However, administration of NSAIDs, along with certain drugs or supplements may reduce the deleterious side effects. This research evaluates the ulcer protective efficacy of the combined dose of Aloe vera and vitamin-E in the Indomethacin-induced ulcerated rats. The therapeutic efficacy of the combined...
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