Posted by admin on May 31, 2019 in |
The aim of the present study is to develop and evaluate the immediate release tablet of Vilazodone by direct compression method. The superdisintegrant crospovidone (CP), croscarmellose sodium (CCS), sodium starch glycolate (SSG), and Locust beam gum were used for the immediate release of drug from the tablet. Optimization of superdisintegrant concentration that can control the release of the drug as the hypothetical release profile was based on the release profile of the prepared trials. The prepared tablets were evaluated for all pre-compression parameters. Evaluation parameters Like weight variation, the hardness of the tablet, friability, thickness, disintegration test, drug content uniformity, and in-vitro release studies were performed. The drug-excipients interaction was investigated by FTIR. All formulation showed compliances with Pharmacopoeial standards. Among all the formulations, a formulation containing croscarmellose sodium as a super disintegrant is fulfilling all the parameters satisfactorily. The study reveals that formulations prepared by direct compression F5 exhibits the highest dissolution using croscarmellose sodium showed faster drug release 96.57% over 30...
Read More
Posted by admin on May 31, 2019 in |
The present study evaluates the antidepressant activity of Nyctanthes arbor-tristis (NT). In the present study antidepressant effects of hydroalcoholic leaf extract (250 & 500 mg/kg) (NTL), flower extract (250 & 500 mg/kg) (NTF) and combination extract (leaf+flower extract in equal ratio) (250 & 500 mg/kg) (NTC) of Nyctanthes arbor-tristis were evaluated by the use of forced swim test. The animals were divided into different groups and were given daily dosing for seven successive days. On the seventh day, the immobility time and locomotor activity were noted down. The locomotor activity was taken before and after dosing. Initial phytochemical investigations showed the presence of some active constituents which were important for the antidepressant activity. All extracts of NT & imipramine treated groups demonstrated a significant reduction of immobility time. There were also statistically remarkable differences in immobility time in groups treated with combination extract compared to groups treated with leaf and flower extract alone. All extracts of NT also showed slight increment in the locomotor activity but were not statistically...
Read More
Posted by admin on May 31, 2019 in |
Although doxorubicin is used widely in animal models to induce cardiotoxicity, serial dose-dependent cardiac effects have not been investigated in experimental animal models to date. Therefore, the objective of this study was to find out the dose-dependent changes of doxorubicin-induced acute cardiotoxicity, both biochemically and histopathologically in Wistar rats. Wistar rats were divided into nine groups. Group 1: normal control; Groups 2-9: eight doses of doxorubicin (13, 14, 15, 16, 17, 18, 19 & 20 mg/kg, intraperitoneal injection, after 16 h fast). Animals were sacrificed on the 4th day, and blood was collected for the estimation of cardiac troponin I (cTnI), aspartate aminotransferase (AST) and superoxide dismutase (SOD) activities and heart tissues were collected for histopathological assessment. Mean cTnI concentrations of groups 1-9 were 0, 39.46 ± 1.8, 60.92 ± 2.7, 87.79 ± 1.8, 116.96 ± 2.7, 147.79 ± 2.3, 163.96 ± 1.5, 197.38 ± 2.3 and 221.54 ± 1.8 pg/mL respectively. In groups 1-9, mean AST activities were 38.90 ± 0.98, 42.23 ± 0.99, 44.07 ± 1.20, 50.77...
Read More
Posted by admin on May 31, 2019 in |
Helicobacter pylori (H. pylori) is a spiral, gram-negative pathogen which causes gastric cancer along with MALT lymphoma. It is widespread among the gut microflora and stands first among the pathogens. Cytotoxin-associated gene (cagA) is thought to be the vital protein in the pathogenesis of gastric cancer. Since there are no available vaccines at the moment, and owing to the increasing antibiotic resistance, studies towards developing a novel vaccine are very much essential. The present study was designed to clone and express the protein cagA within the bacterial systems. The protein fragment was screened for antigenic properties using in-silico studies. The protein of interest was confirmed using the western blots. This study further can be planned to produce a novel peptide...
Read More
Posted by admin on May 31, 2019 in |
Present study highlights that plant as a source of medicine has been inherited and is an important component of the health care system in India. Ziziphus mauritiana fruit (Rhamnaceae), one of the medicinally important plants commonly found in subtropical countries, was chromatographically evaluated in the present work for the identification of various phytochemical compounds found in it. The phytochemical tests showed the presence of alkaloids, flavonoids, phenols, saponins, tannins in methanolic extract of Ziziphus mauritiana (MEZM). Majorly 24 compounds in 93.08% peak area were identified through spectrum matching with National Institute Standard and Technology (NIST) database. In accordance with known therapeutic effects of the identified compounds like 5-Hydroxymethyl furfural; 1, 5-Anhydroglucitrol; Polygalitol; Sedoheptulosan; D-Allose; Beta-D-Glucopyranoside Methyl; 3, 4-Altrosan; Nonanoic acid; Octanoic acid; 2-Hexyl- 2-Hexadecanoic acid; 2-Propyloctanoic acid; Molinate; Levetriracetam; Clindamycin and Maltol, the MEZM fruit’s justified a very good source of therapeutic agents for Cancer, Epilepsy, Alzheimer’s disease, Parkinson disease, Amyotrophic Lateral Sclerosis (ALS), bacterial and fungal infections. Also, it is rich in compounds comprising anti-oxidant, anti-spermatogenic, anti-biotic, neuroprotective...
Read More
