Posted by admin on Jun 30, 2019 in |
Expansion of secondary metabolites from marine resources mainly from echinoderms has been a subject of intense research due to massive bioactive nature. Isolation of new secondary metabolites from sea stars has been found to be highly polar. An initial assessment and validation of these compounds are necessary to assess human risk. Zebrafish are used as a part of a diverse phase of the drug discovery development and has proved to be a constructive and cost-effective alternative to various mammalian models. The current study was performed to observe the effect of sterol isolate from Stellaster equestris on Zebrafish (Danio rerio). The selected active crude extract (which showed enhanced cytotoxic activity) was subjected to purification and was characterized by spectroscopic analysis. The absorption frequency of the FTIR and NMR analysis resembled the absorption frequency of a steroidal compound. The analyzed compound was then evaluated for toxicity using Danio rerio using DNA fragmentation assay, Embryotoxicity, Fin regeneration, and Cardiotoxicity assay as the endpoints. The fishes were exposed to 4 different concentrations (50...
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Posted by admin on Jun 30, 2019 in |
To assess the effect of Perillyl alcohol (POH) on the lipid profile of high-fat-diet-induced hyperlipidemia in white male albino Wistar rats, the hyperlipidemia was induced by feeding cholesterol-rich high-fat diet for 45 days in male albino Wistar rats. The decline in the triglycerides, LDL and VLDL was significant at 100 & 200 mg/kg dose of POH compared to Atorvastatin group. The decrease in total cholesterol was significant at 100 and 200 mg/kg doses compared to hyperlipidemic control. The results demonstrate that POH at a dose of 100 and 200 mg/kg body weight lowers the serum triglyceride, LDL, VLDL, total cholesterol and increase HDL level significantly in high-fat-diet-induced hyperlipidemic rats. Though there was no significant effect on the lipid profile at 50 mg/kg dose. Thus, the results of the present study provide scientific validation for the use of Perillyl alcohol (POH) a terpene as an Antihyperlipidemic...
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Posted by admin on Jun 30, 2019 in |
The purpose of the research was to assess the prescribing pattern in geriatrics and to analyze the prescription using World Health Organization (WHO) core prescribing indicators and American Geriatric Society (AGS) Beers criteria 2012 for potentially inappropriate medication use in older adults. This prospective drug utilization study was conducted for a period of 6-months. Patients of either gender, age 65 or above who were admitted in the secondary care hospital. Collected data were analyzed with the WHO core prescribing indicators and American Geriatric Society Beers criteria 2012 for potentially inappropriate medication use in older adults. A total of 200 patients were taken in the study. The majority of the patients were in the age group of 65-70 years (64%) with male predominance (53%). The average number of drugs per encounter was 6.86. Out of 1372 drugs, 1157 drugs (84.32%) were prescribed by generic name. Drugs acting on the cardiovascular system (27.92%) were the most commonly prescribed. In this study, Ranitidine (24.4%) is the most commonly prescribed drug. The study...
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Posted by admin on Jun 30, 2019 in |
Entamoeba histolytic is a protozoan parasite which causes amoebiasis, about 50 million people are affected yearly, and it caused more than 100,000 deaths per year. The study investigates the therapeutic effect of ethanolic and aqueous Tamarindus indica leaves extracts on infected rats with Entamoeba histolytica. Twenty-one Rattus norvegicus rats were infected with Entamoeba histolytica and divided into seven groups (three rats in each group). Groups (1, 2, and 3) were treated with aqueous Tamarindus indica extracts at doses 125, 250, and 500 mg/kg respectively for ten days. Groups (4, 5 and 6) were treated with ethanolic extract of Tamarindus indica at doses 125, 250, and 500 mg/kg respectively for ten days. Group (7) was left untreated as a positive control group. The results showed a significant decrease at p≤0.05 in the numbers of parasite cell from the second day of treatment in all the groups treated with aqueous as well as ethanolic extract. This decrease gradually continued during the days of treatment until it reached zero on the last...
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Posted by admin on Jun 30, 2019 in |
The pharmaceutical market of the Russian Federation receives medicines produced both in compliance with the international standards of good manufacturing practice and those coming from developing countries where manufacturers operate according to their national regulations. Asparagus racemosus is a medicinal plant that is widely used in oriental medicine and is included in the Ayurvedic pharmacopeia. The plant, among others contains steroid saponins, isoflavones, and polysaccharides. The roots of Asparagus racemosus are used as a phytoestrogen in disorders of the hormonal system by women. The plant is also known for its antioxidant, immunostimulating, and anti-inflammatory effects. The Russian State Pharmacopoeia (RSP), XIII edition does not include this plant species. However, medicinal plant raw materials (MPRM) and remedies based on them do enter the Russian pharmaceutical market. Therefore, the main objective of this study is to determine the quality and safety of raw Asparagus racemosus. We determinedsuch parameters of quality and safety as: extractive values i.e. alcohol soluble and water soluble; ash values: total ash, ash insoluble in 10% hydrochloric acid...
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