Posted by admin on May 31, 2019 in |
Liquid electrodes of polymers imprinted with Isopropamide (ISP) were synthesized based on precipitation polymerization mechanism. The molecularly imprinted polymer (MIP) and non-imprinted polymers (NIP) were synthesized using (ISP) as a template. In the polymerization process, 2-Hydroxyethyl meth acrylate (2-HEMA) and 2-Vinyl pyridine (2-VP) were used as monomers. Di-vinylbanzene (DVB) was used as cross-linkers and benzoyl peroxide (BPO) as an initiator. The molecularly imprinted membranes and the molecularly non-imprinted membranes were synthesized using dibutyl sebacate (DBS) and nitrobenzene (NB) as plasticizers in PVC matrix. Slopes and detection limit of the liquid electrodes are ranged at (52.23-58.94) mV/decade and (1.2 × 10-6 – 2.0 × 10-5) M, respectively. Response time was 60 sec. Liquid electrodes were filled with 10-1 M standard solution of drug and observed stable response for a pH ranged from 1.5 to 12 and with good selectivity for over several species. The new synthesis electrodes were successfully used for the analyte estimated in preparation pharmaceutical sample without any time-consuming pre-treatment...
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Posted by admin on May 31, 2019 in |
Wild fruits play a significant role in human nutrition, especially as sources of carbohydrates, proteins, vitamins, minerals, dietary fibers, and enormous medicinal potential. Local people in different parts of the country have learned to live on many wild edible fruits available around their localities. Artocarpus hirsutus Lam. is an important wild edible fruit plant belongs to the family Moraceae and is commonly known as Wild Jackfruit, Ayani, Aanjili, etc. The present study was to trace out the variations in the profile of bioactive compounds from petroleum ether and chloroform extracts of Artocarpus hirsutus fresh fruit pulp using Gas chromatography-Mass spectrometry analysis (GC-MS). The identification of the bioactive components of the extracts was established by GC retention indices, by comparing their mass spectra with National Institute of Standards and Technology (NIST) data center. According to GC-MS spectral data, in petroleum ether extract five major compounds were identified. And in chloroform extract, seven major compounds were...
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Posted by admin on May 31, 2019 in |
Epilepsy is a disorder of the central nervous system. A seizure occurs when the brain’s nerve cells misfire and generate a sudden uncontrolled surge of electrical activity in the brain. Seizures can be controlled with modern medicines and surgical techniques and are found to have so many side effects. Natural products from folk remedies are an alternative source of anti-epileptic drugs with better safety and efficacy profiles. Rubiadin is an anthraquinone glycoside isolated from roots of Rubia cordifoia (Manjishta) known for several pharmacological activities. The present study was aimed to assess the anti-epileptic activity of isolated rubiadin from Rubia cordifolia. The evaluation of anti-epileptic activity was carried out with maximal electric shock (MES) and Pentylene Tetrazole (PTZ) models. The epileptic seizure was induced in mice of either sex and the challenged animals treated with whole Rubia cordifolia root extract & isolated Rubiadin suspension at two doses 100 mg & 250 mg respectively. The isolated Rubiadin suspension at 250 mg dose showed a significant reduction in MES and PTZ induced...
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Posted by admin on May 12, 2019 in |
In the present work, we have measured natural radioactivity in twelve building materials samples for four kinds (Brick, cement, gypsum and sand) obtained from some Iraqi governorates by using High Purity Germanium (HPGe) radiation detectors system. The results of measurements have shown that the average values specific activity concentrations for 238U, 232Th and 40K which were equal to (24.236 ± 4.4 Bq/kg), (26.394 ± 4.0 Bq/kg) and (174.888 ± 29.1 Bq/kg), respectively., which were lesser than the corresponding recommended global values reported by (UNSCEAR, 2000) publication. The radiation hazard indices [Raeq DƔ, (AED)in, (AED)out, Hin and Hex] were also studied. The obtained results were also found to be lesser than the allowed limits given by (UNSCEAR, 2000). Thus, all results obtained in the present work have shown no significant radiological hazard when the studied building materials is used for construction of...
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Posted by admin on Apr 30, 2019 in |
A simple, specific, accurate and precise and stability indicating RP-HPLC method was developed and validated for the simultaneous estimation of Amlodipine Besylate and Valsartan in pharmaceutical formulation. The method was developed using Enable C 18G column (250 × 4.6 mm, 0.5 µm) with a mobile phase consisting of sodium acetate buffer (pH 5.0) and methanol (35:65% v/v) with a flow rate of 1 mL/min. The UV detection was carried out at 234 nm. The retention time for Amlodipine Besylate and Valsartan were found to be 3.146 and 6.543 min respectively. The proposed method was validated for linearity, range, accuracy, precision, robustness, LOD and LOQ. Linearity was observed over a concentration range 0.5-250 µg/ml for amlodipine besylate (r2 = 0.9996) and 1-90 µg/ml for Valsartan (r2 = 0.9984). The % RSD for Intraday and Interday precision was found to be 0.37 and 0.57 for Amlodipine Besylate and 0.48 and 0.75 for Valsartan. The LOD and LOQ were found to be 0.01 µg/ml, and 0.04 µg/ml for Amlodipine Besylate and LOD...
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