Posted by admin on Apr 30, 2019 in |
Background: Musa balbisiana Colla (Musaceae family) is used as folkloric medicine throughout India. Objective: To search out the potent dose of a hydro-methanolic extract of Musa balbisiana flower for antidiabetic and antioxidative activities in streptozotocin-induced diabetic rat. Material and Methods: The extract of the said plant part was administered orally at the dose of 5, 10 or 20 mg /100 g body weight for 28 days. Diabetes was induced by a single intramuscular injection of streptozotocin at the dose of 4 mg / 0.1 ml of citrate buffer / 100 g body weight to Wistar stain albino male rat. Biochemical, histological and thin layer chromatographic profiles were studied. Results: Treatment with 10 mg or 20 mg doses exhibited a significant recovery from diabetes by decreasing fasting blood glucose and glycated hemoglobin levels along with increasing the serum insulin level. Significant recovery was noted in antioxidative and carbohydrate metabolic enzymes’ activities in hepatic and skeletomuscular tissues in diabetic rat. The extract had no metabolic toxicity. From the qualitative phytochemical analysis...
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Posted by admin on Apr 30, 2019 in |
Globally, foodborne pathogens are the origin of diseases and deaths. To prevent the foodborne pathogens billions of dollars spending. Coliforms level, psychrotrophs mesophiles, E. coli, and Staphylococcus aureus, are routinely assessed to determine microbial safety, sanitation conditions, improper hygiene in poultry carcasses. Thai-population consumes more broiler meat due to its availability and eases to cook, although it could be potential to contaminate with wide varieties of microorganisms. Salmonella, Escherichia coli, Staphylococcus aureus, Campylobacter, and Listeria are the most common food born pathogenic microorganisms. Presence of pathogenic microorganisms in meat could be harmful to human and potential to cause food spoilage. Hence, this can be used as indicator organisms to detect the pathogenicity of food, especially in meat and meat products. Therefore, this study aimed to investigate the prevalence of pathogenic microorganisms, which causes food poisoning in broiler meat as well as discusses concerning public health importance. The findings of this study suggest that the consumption of cross-contaminated meat with pathogenic organisms may pose a serious threat to local consumers....
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Posted by admin on Apr 30, 2019 in |
This study sought to evaluate the heavy metal content of the raw powder and extract of the plant, the phytochemical constituents, antioxidant effect by the use of DPPH assay, the total phenolic content using Folin Ciocalteu assay and the cytotoxic effect using the MTT Assay of Ficus pumila ethanolic extract, methanolic and hydro fractions on liver cancer cells (HepG2), Leukemic cells (Jurkat) and normal liver cells (Chang). FTIR and Gas Chromatography-Mass Spectrometry (GC-MS) was used to identify the functional groups and major constituents of the most active fraction of F. pumila. Alkaloids, terpenoids, flavonoids, cardiac glycoside, saponins, and tannins were present in the ethanolic extract of F. pumila. The heavy metal analysis revealed the presence of Iron in both the raw powder (1.97 ± 0.11 mg/l) and extract (0.92 ± 0.02 mg/L). Zinc was also detected in both the raw powder (1.19 ± 0.00 mg/l) and extract (0.6595 ± 0.02 mg/l). The results from the FTIR revealed the presence of alkynes, alkyl halides, aromatics and aliphatic amines common to...
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Posted by admin on Apr 30, 2019 in |
Dipterocarpus gracilis Blume is one tropical species of Dipterocarps which is included in the red list IUCN as a rare and endangered tree species. In consideration of Dipterocarpus gracilis Blume conservation and sustainability of its oleoresin, this present study aimed to determine specific characteristics of oleoresin origin of Dipterocarpus gracilis Blume as an establishing basis for appropriate product diversification of human remedy. Here, is also evaluated the presence of different phytochemical along with GC-MS investigations of water and ethanol soluble crude extracts, and anti-oxidant obtained in oleoresin. The results showed that oleoresin of Dipterocarpus gracilis Blume revealed the presence of alkaloid and triterpenoid, whereas antioxidant activity test had low in 95% ethanol soluble. While, GC-MS analysis of organic compound of oleoresin of Dipterocarpus gracilis Blume identified that the most organic compound such as Caryophyllene, Caryophyllene oxide, Cyclohexanepropanal, 2,2-dimethyl-6-methylene-, 2, 6, 10, 14, 18, 22-, Tetracosahexaene, 2, 6, 10, 15, 19, 23-hexamethyl-, (all-E)-, 4-Pregnen-21-ol-3,20-dione glucoside, 1,4-Methanophthalazine, 1, 4, 4a, 7, 8, 8a-hexahydro-9,9-dimethyl-, (1α, 4α, 4a α, 8a α)-, and 9,...
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Posted by admin on Apr 30, 2019 in |
Marine organisms are excellent sources of structurally diverse molecules that are potentially valuable as drugs. The brittle starfish was shown to contain the bioactive components which exhibit various biological activities including cytotoxicity effects. Hence, the present study was carried out to determine the cytotoxicity of the extracts of two different starfish species like Ophiocoma erinaceus and Ophiomastrix annulosa. The homogenized fresh body component of brittle starfish was extracted and concentrated. The cytotoxic effect of EtOH extract of Ophiocoma erinaceus and Ophiomastrix annulosa against cancer cell lines was determined by MTT assay. In this study, it was observed that the extracts induce a concentration-dependent inhibition of cells against MCF -7, VERO and HELA cell line at a lower concentration. Based on abundance, the top three major compounds present in the O. erinaceus were n-Nonadecanol-1 (24.643), Ethyl 9-hexadecenoate (26.437) and hexadecanoic acid, ethyl ester (26.868). The starfish extract exhibited strong cytotoxicity against cancer cells. Overall, these findings confirmed the utility of clinical investigations of the efficacy of starfish extracts in preventing...
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