Posted by admin on Feb 28, 2019 in |
Euphorbia neriifolia and Euphorbia hirta have been traditionally used for relieving anxiety and other nervous disorders. The present study was designed to evaluate and compare the antianxiety activity of E. nerrifolia leaves and E. hirta aerial parts using elevated plus maze model. Petroleum ether (60-80°C), chloroform, ethanol and aqueous extracts of both the plants were prepared and evaluated for antianxiety activity. Chloroform extract of E. neriifolia and ethanol extract of E. hirta showed significant antianxiety activity at the dose of 200 and 400 mg/kg, respectively, comparable to that of diazepam (2 mg/kg). The study was extended to develop the TLC fingerprint profile of the two plants using CAMAG HPTLC system, and the relative percentage of the separated constituents was calculated from the area of peaks. Further, phytochemical screening of the bioactive chloroform extract of E. neriifolia showed the presence of flavonoids, steroids/terpenoids, phenols, and tannins while the bioactive ethanol extract of E. hirta tested positive for flavonoids and...
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Posted by admin on Feb 28, 2019 in |
Background: Cutaneous adverse drug reactions (CADRs), having a wide range in terms of its spectrum, are an important cause of morbidity and mortality. They comprise 2-3% of all ADRs. This study was conducted to analyze various parameters of CADRs at our setup. Methodology: This prospective, observational study was carried out for 1 year at our setup after ethical approval. Those diagnosed as CADRs by the Dermatologist were included. Data was collected in suspected ADR reporting form and analyzed for various parameters like suspected drug and drug class for CADRs, spectrum as well as its type, severity, preventability, causality assessment, seriousness, and outcome. The lag period for the development of CADRs was also analyzed. This data collection was also uploaded via Vigiflow under Pharmacovigilance Programme of India (PvPI). Results: Total of 125 cases were recorded with 134 CADRs. These 134 cases included a wide range comprising of 27.61% rashes to 5.97% Stevens-Johnson syndrome (SJS). For these CADRs, most common suspected drug classes were anti-infectives (34.32%) followed by NSAIDs (29.10%) whereas...
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Posted by admin on Feb 28, 2019 in |
An alternative energy sources using the sweet orange (Citrus sinensis (L.) waste as the feedstock was investigated; this is an approach to environmental protection. The extraction of pectin from sweet orange peel waste (pith) and the production of ethanol from the resultant liquid pectin with the aid of Escherichia coli (E. coli) and Saccharomyces cerevisiae (yeast) were carried out. Dried pith was separated using various particle sizes ranging from 0.075, 0.5, 1.0 and 5 mm. It was observed that pith with a particle size of 1.0 mm produced a larger volume of pectin while the pith with a particle size of 0.075 mm produced the least volume of pectin. 1,770 ml pectin was obtained from 802 g of pith; this shows that citrus fruit (especially orange) contains a high amount of pectin. E. coli (bacteria), yeast (fungus) and a mixture of both were added to the produced pectin which was fermented to ethanol. It was however noticed that sample pectin + E. coli + yeast, and sample pectin +...
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Posted by admin on Feb 28, 2019 in |
The antidiabetic and anti-inflammatory effects of probiotic Lactobacillus fermentum MCC3216 was investigated in high fructose-fed type 2 diabetic rats. Type 2 diabetes was induced by feeding high fructose diet to male albino Wistar rats. A single daily dose of 2 × 108 CFU/ml of L. fermentum MCC3216 was given to Wistar rats for 8 weeks. The fasting blood glucose, body weight, oral glucose tolerance test, glycosylated hemoglobin, insulin, liver glycogen, lipid profile, and oxidative stress parameters were measured. The level of Interleukin-6 and Interleukin-10 were also measured in serum. Histopathology analysis of pancreas and liver injury were performed. At 8 week L. fermentum MCC3216 significantly (P<0.05) decrease FBG, body weight, glucose intolerance, HbA1c, insulin, liver glycogen, total cholesterol, triacylglycerol, LDL-C, VLDL-C, lipid peroxidation and IL-6 level as compared to diabetic rats. The values for HDL-C, reduced glutathione, superoxide dismutase, catalase and IL-10 were significantly (P<0.05) increased in L. fermentum MCC3216 treated group as compared to diabetic rats. Islets of Langerhans and hepatic cells in L. fermentum MCC3216 treated group...
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Posted by admin on Feb 28, 2019 in |
A floating controlled drug delivery system of loratadine was formulated to enhance the retention time in the stomach and to modify the release characteristics of loratadine. Loratadine loaded floating gel beads were prepared by ionic gelation technique using different polymers such as HPMC K4M, HPMC K15M, and carbopol 934P in different proportions and sodium bicarbonate as the gas forming agent. FT-IR spectra revealed that there was no significant interaction of loratadine with the carriers and other excipients. The prepared beads were evaluated for particle size analysis, bulk density, tapped density, compressibility index, hausner’s ratio, the angle of repose, swelling index, drug entrapment efficiency, % yield, % buoyancy of loratadine floating beads, in-vitro drug release studies, kinetic modeling of drug release and stability studies. Results of the in-vitro drug release study indicated sustained release of loratadine for up to 12 h. The drug release kinetics of optimized formulation F7 was best fitted with the zero order and Peppas model with...
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