Posted by admin on Apr 30, 2019 in |
Background & Objectives: Standardization of polyherbal Unani formulations is essential to assess the quality of drugs, based on their active principles, physical and chemical standards. This work reports on standardization of a polyherbal Unani powder formulation Safoofe- Musakkin (SM) consist of Rauwolfia serpentina Benth. Ex kurz root, Coriandrum sativum Linn. seed and Piper nigrum Linn. fruit. It is used in neurological disorders. Methods and Material: Plant parts were first cleaned, dried in the shade and powdered by passing through sieve # no. 80 and prepared as per the method described in UPI. SM formulation was evaluated using physicochemical tests: powder characterization, extractive value, alcohol, and water-soluble matter, Ash value, LOD at 105 ºC, pH and HPTLC fingerprinting. Statistical Analysis Used: Mean ± SEM. Result: Organoleptic characters of SM revealed brown color, characteristic odor, bitter taste, and moderately fine texture. Physicochemical parameters resulted in water-soluble extractive (9.58 ± 0.11), alcohol-soluble extractive (6.29 ± 0.07), total ash (5.87 ± 0.09), acid insoluble ash (3.09 ± 0.08), water-soluble ash (1.5 ± 0.05),...
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Posted by admin on Apr 30, 2019 in |
Atherosclerosis results from the slow deposition of fatty materials in media and large arteries leading to mortality worldwide. Terminalia arjuna is an herb of Combretaceae family which contains flavonoids, terpenoids, cardiac glycosides with high antioxidant properties. This study was conducted to determine the effect of hydroalcoholic extract fraction of T. arjuna on blood lipids and atherosclerosis in hyperlipidemia Wistar rats model induced by atherogenic diet. In the hyperlipidemia animal model, the rats received a hydroalcoholic extract of T. arjuna treatment exhibits a noticeable reduction in total cholesterol, total triglycerides and elevation in high-density lipoprotein cholesterol (HDL-C). A result reveals that T. arjuna considerably decreases TC, TG and increases antioxidant levels. Metabolic marker of homocysteine, pro-inflammatory (adipocytokines) markers such as C-reactive protein, leptin, and IL6, anti-inflammatory marker like adiponectin, fibrinolytic factors such as plasminogen activator (PA) and plasminogen activator inhibitor (PAI) that are an association with atherogenic diet consumption. Hence, T. arjuna extract can effectively prevent the progress of atherosclerosis. This is possible due to the effect of T. arjuna...
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Posted by admin on Apr 30, 2019 in |
Introduction: Schizophrenia is a chronic and debilitating psychiatric illness affecting around 0.4% to 1.4% of people at some point in their life. Early onset and the chronic course make schizophrenia a worrying disease. Prescribing pattern in Schizophrenia has seen a significant shift in the last two decades, from the first generation to second-generation antipsychotics. This study was carried out to analyze the pattern of antipsychotic drug utilization in patients of schizophrenia presenting at an outpatient department of a tertiary hospital. Materials and Methods: A cross-sectional observational study was conducted at the psychiatry outpatient department of a tertiary care hospital for six months. Diagnosis of Schizophrenia was made according to DSM – 5 criteria. Prescriptions were analyzed for demographic details, and the psychotropic prescribing pattern was studied using WHO indicators. Results: Amongst 104 prescriptions, 59.61% were males, and 68.20% of study subjects were below 40 years. 95.96% prescriptions were of atypical antipsychotics, Risperidone being the most commonly prescribed (52.88%), followed by Olanzapine (28.84%). Antipsychotic polypharmacy was noted in 19.23% of...
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Posted by admin on Apr 30, 2019 in |
The main objective was to study the prescribing pattern of antibiotic in a tertiary care hospital to assess the frequency and prescribing the practice of antibiotics. The study includes an observational study of antibiotic prescribing patterns conducted over 6 months. In this study, enrolled 300 patients who were prescribed with antibiotics from both outpatient and inpatient department. Data were collected from the patient’s chart and was subjected to analyze by performing descriptive statistics. In the present study, the prescription was assessed and found the maximum number of patients belonged to the age group of 21-30 years, and the proportion of male patients was more compared to the female patients. Moreover, younger and adult patients were commonly associated with the highest prescribed antibiotics in both male and female patients. Also observed that the frequency of antibiotics were 1, 2, and 3 or > 3 prescribed to 55%, 26%, and 19% respectively. Among the all group of antibiotics cephalosporins was found to be prescribed to the largest number (22.03%) of patients,...
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Posted by admin on Apr 30, 2019 in |
Mucositis is a foremost acute complication in the clinical setting, occurring in a large percentage of patients undergoing cytotoxic therapy. One of the major problems with mucositis is that the underlying mechanisms behind its development are not wholly understood, which makes it extremely difficult to develop effective interventions. Animal models provide a critical source of knowledge when sampling from patients is unavailable, or interventions are yet to be fully tested. The object of the study is to evaluate the potential effectiveness of optimized L-glutamine hydrogel formulation used in the buccal cavity; we used a rat model for oral mucositis induced by 5-fluorouracil. Studies have shown that the blend of mild abrasion of the cheek pouch and two doses of 5-fluorouracil (60- 40 mg/kg) induced oral mucositis and the reduction of body weight. Optimized hydrogel formulations CP4 and GSH14 shown significant weight gain as compared to the control group. This study shows that the prepared hydrogel is effective in oral mucositis and effective to control oral mucositis. The rationale selection...
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