Posted by admin on May 31, 2024 in |
Background: Chronic kidney disease (CKD) is defined as either kidney damage or a decreased glomerular filtration rate (GFR) of less than 60 mL/min/1.73m2 for 3 or more months. The prevalence of CKD in India is 17.2% and it is substantially higher in hypertension, Diabetes, and vascular disease patients. Polypharmacy potentiates the risk of medication-related problems, such as drug-drug interactions and complex drug. Objective: To assess the pattern of prescription and drug interactions in chronic kidney disease patients. Methodology: It was a cross-sectional study done from November 2022 to April 2023. The study was conducted on 60 in patients diagnosed with CKD in the Department of General Medicine in Victoria Hospital attached to BMCRI. The pattern of prescription was assessed in addition drug interactions were assessed by using Medscape – an online drug interactions checker. Results: The data demonstrated that most of the patients who were diagnosed with CKD were males (60%) and in the age group of less than 60 years (88%). 50% of patients belong to CKD stage...
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Posted by admin on Apr 30, 2024 in |
Lacosamide is an antiepileptic bitter drug used to treat partial onset seizure. The aim of the work was to mask the taste of lacosamide and then formulation and evaluation of tablet. Taste was masked using spray dryer. Oral disintegrating tablet was prepared using 3 superdisintegrants Sodium starch glycolate, Crosscarmellose sodium and Polyplasdone XL10. Out of these polyplasdone showed quick disintegration. The 32 factorial experimental design was applied to optimize response variable disintegration time and drug release. Tablet from optimized batch (F9) disintegrate within 27 seconds with 99.38% drug...
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Posted by admin on Apr 30, 2024 in |
Periumbilical perforating pseudoxanthoma elasticum (PPPXE) presents as well-defined, yellowish, atrophic plaques encircling keratotic papules, often observed in obese, multiparous women. This dermatosis is considered either a localized acquired cutaneous disorder or a variant of hereditary pseudoxanthoma elasticum. We report a case clinically diagnosed with differentials but confirmed as PPPXE through histopathological examination. The patient, a middle-aged woman, presented with characteristic lesions in the periumbilical region, prompting consideration of various differential diagnoses. However, microscopic analysis revealed the distinctive features of perforating pseudoxanthoma elasticum, including the presence of transepidermal elimination channels and abnormal elastic fibers. This case underscores the importance of histopathological evaluation in confirming the diagnosis of PPPXE, especially when clinical presentation overlaps with other cutaneous conditions. Awareness of this entity is crucial for accurate diagnosis and appropriate management, given its potential implications for systemic health. Further research is warranted to elucidate the pathogenesis and optimal treatment strategies for PPPXE. Our case contributes to the expanding literature on this rare dermatosis, emphasizing the significance of a multidisciplinary approach involving dermatologists...
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Posted by admin on Apr 30, 2024 in |
Around the world, cancer frequently leads to death. Lung cancer is the primary cause of cancer-related deaths globally. Through in-silico analysis, this study sought to assess the anticancer effectiveness of myricetin on human lung cancer cells. The study’s goal is to assess how well myricetin adheres to the Lipinski rule of 5. To evaluate the ADMET properties (Absorption, Distribution, Metabolism, Excretion, Toxicity) for myricetin. To predict the target-ligand interaction. The results from these studies supported that the myricetin follows the Lipinski rule of 5 and ADMET properties. Myricetin has a better H bond interaction. The results of the in-silico analysis used in this work serve as encouraging evidence for the prediction of the mechanism by which myricetin acts to cause apoptosis via the EGFR pathway. The results from the molecular docking study suggested that myricetin inhibited critical tumorigenic effects through apoptosis. Thus myricetin could be further explored as a promising chemotherapeutic agent in lung cancer...
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Posted by admin on Apr 30, 2024 in |
Testicular toxicity has been associated with long-term paracetamol usage. Moringa oleifera is known to eliminate toxins from organs and restore functionality. This study seeks to ascertain the potency of moringa in ameliorating paracetamol-induced testicular toxicity. Forty nine (49) Sprague-Dawley rats were randomly assigned into seven (7) groups composed of 7 rats each treated for 5 weeks. One group served as the control, while 3 other groups were administered graded doses of paracetamol, then the other 3 groups were administered graded doses of paracetamol and 1600mg/kg of moringa extracts simultaneously. The animals were sacrificed 24 hours after the administration of last dose using anaesthesia. The testes and epididymis were harvested, while blood was obtained via ocular puncture. The moringa extract mitigated the paracetamol-induced dose-dependent decrease in sperm count and sperm morphology. Paracetamol toxicity on hormonal milieu was suppressed by the moringa extract treatment, yielding hormonal values closer to those obtained in the control group. The moringa extract treatment controlled the oxidative stress biomarkers as their values were not as variant...
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