Posted by admin on Sep 30, 2024 in |
Pharmaceutical corporations have been heavily involved in the development of natural plant-based goods to create the most economical and cost-effective medicines for the underprivileged in recent years. Plants are abundant natural product suppliers. One of such natural sources having great medicinal value is Croton bonplandianum, commonly known as ‘bantulasi’; Family: Euphorbiaceae. Because Croton bonplandianum is an alien plant species, the presence of alkaloids, flavonoids, saponins, steroids, resins, phenols, and rutin gives rise to its very useful medicinal value. It is used to treat skin problems, wounds, and high blood pressure. Three distinct guinea pig and frog experimental models were used in this investigation to screen the Croton bonplandianum extracts. The extract at dilutions 1:10, 1:50 and 1:100 showed the anesthetic activity in a dose-dependent manner in contrast to the typical medication xylocaine (0.2%). The techniques include lumbar plexus anesthesia, nerve block anesthesia, frog muscle twitch, guinea pig infiltration anesthesia, and surface anesthesia in rabbits. It was concluded that extracts of Croton bonplandianum possess local anesthetic...
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Posted by admin on Sep 30, 2024 in |
Background: Epilepsy, characterized by repetitive seizures, is studied using pentylenetetrazole (PTZ) in animals. PTZ, a GABA-A inhibitor, is used in various doses in mice to evaluate drug efficacy against seizures. Method: In a PTZ-induced mouse model, different PTZ doses were evaluated: 80 mg/kg i.p., 75 mg/kg i.p., and 80 mg/kg s.c. Seizure behaviors were analyzed, including mortality rates, GTCS frequency and latency, myoclonic jerks, GTCS duration, and post-injection interictal phase duration. Results: Frequency of GTCS was found to be highest, latency to GTCS and myoclonic jerks was least and duration of GTCS was more in PTZ 80 mg/kg, i.p., group, while the PTZ 80 mg/kg; s.c. was found to have longest inter-ictal phase. These are important criterion for the evaluation of any investigational drug for antiepileptic effect. The mortality rate was found to be the same in PTZ 75 mg/kg; i.p. and 80 mg/kg; s.c. (12.5%) groups, while in PTZ 80 mg/kg; i.p. it was found to be highest (25%). The PTZ 80 mg/kg, i.p., for comparison of seizure...
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Posted by admin on Sep 30, 2024 in |
Aim: The aim of present work is to analytical estimation and process validation of conventional tablet dosage form of Meloxicam. Materials and Methods: Tablets were prepared by wet granulation method. Then coating is done as film coating. Results and Discussion: Melting point, pH of drug was measured in triplicate and mean was notedi.e.253°C, 3.9. The maximum absorption was found to be 350 nm by UV. Various tests like Angle of repose, Bulk density, tapped density, Carr’s Index and Hausner’s ratio are performed at blend stage. Dissolution test and assay is performed of all the three batches. A kinetics study is performed for all the three batches and the result was found satisfactory. Conclusion: Results of the performed tests are to be assessed & summarized to confirm that the procedures followed consistently meet its pre-determined specifications and quality attributes. No maximum variation is found in results. So, our product is...
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Posted by admin on Sep 30, 2024 in |
The study was aimed at development of voglibose mouth dissolving tablets which can disintegrate or dissolve rapidly once place in the oral cavity. Voglibose is alpha glycosidase inhibitor, drug which is used in a treatment of type 2 diabetes mellitus. The tablets were prepared with different super disintegrant like crospovidone, sodium starch glycolate and lactose at different concentrations. The blend was evaluated for angle of repose, bulk density, tapped density, carr’s index, Hausner’s ratio and IR studies. The tablets were evaluated for hardness, friability, weight variation, content uniformity test, disintegration test, wetting time. The most satisfactory formulation F6 showed minimum disintegration time of 31 sec and release maximum amount of drug in shortest duration of time in 10 min. it was found to be stable during short term stability studies. Compatibility studies confirmed the absence of any interaction between Voglibose and the selected excipients. The optimized formulation exhibited excellent disintegration time and dissolution profile, meeting the pharmacopoeia requirements for MDTs. Furthermore, sensory evaluation revealed improved palatability compared to conventional...
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Posted by admin on Sep 30, 2024 in |
The local tribes have used Phyllanthus virgatus for Malnutrition, Contagious infections, Inflammations (Gond Tribe), Hepatitis, Cold, Stomach-ache, Gonorrhoea, Fever, Headache, and septic ailments (Chenchus and Yanadis), etc. The gold nanoparticles have a highly specific surface area, and their unique physiochemical characteristics include catalytic activities, optimal properties, antimicrobial activity, etc. Aqueous leaf extract of Phyllanthus virgatus is used to synthesize gold Nanoparticles. The confirmation of biosynthesis of gold nanoparticles was characterized using UV Spectrophotometer, with the maximum scale observed at 551nm. SEM and EDX characterized the morphology of Gold Nanoparticles used to detect the presence of the element gold. The synthesized Nanoparticles were observed to be roughly spherical with a range of 2-50 µm. The dynamic light technique measured the hydrodynamic diameter (28.7nm) and a Zeta potential (-18.6mV). The FTIR analogue shows that the functional group assigned as=C-H, C-C, O-H, –C=C- and –C=O capping agents. The synthesized nanoparticles have shown strong inhibitory action against pathogenic microbial Strains using the Disc diffusion method. Bacillus cereus exhibited more significant results than other...
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