Posted by admin on Feb 28, 2019 in |
This study reports the potential of a marine mollusk, Chicoreus sp., as a producer of peroxisome proliferator activated receptor-gamma (PPAR-γ) ligand that activate the scavenger receptor class B type 1 (SR-B1) for anti-atherosclerotic activity. The objective of this study is to determine the cytotoxicity of the obtained compound C35, with a molecular weight of 270.1 and the level of SR-B1 expression of a hepatocellular carcinoma cell line (HepG2) after treatment with the compound. Various concentrations of compound C35 were treated against HepG2 to determine its cytotoxicity level (MTS assay) and against transfected HepG2 with SR-B1 promoter (luciferase assay). A non-toxic result obtained in MTS assay where the IC50 is exceeding 100 µg/mL. For luciferase activities, the compound increases the transcriptional regulations of SR-B1 promoter at specific effective concentrations of 12.5 µg/ml with 1.8-fold higher as compared to the positive control. The compound increased the transcriptional regulations of SR-B1 promoter activity and subsequently increased the luciferase activity of the assay system which also reflects the ability of it as a...
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Posted by admin on Feb 28, 2019 in |
A series of novel Imidazo[1,2-a]pyridine derivatives were synthesized in satisfactory yield by microwave assisted synthetic method. The structures of the newly synthesized compounds are characterized by 1H-nuclear magnetic resonance (NMR), Fourier transformed infrared (FTIR), mass spectral analysis (LC-MS) and screened for their in-vitro anti-inflammatory activity. Among the synthesized compounds N-(3,5-bis(trifluoromethyl)benzyl)-4-((2-(6-methyl-2-(p-tolyl)imidazo [1,2-a] pyridine-3-yl) acetamido) methyl) benzamide and N- (4-methoxybenzyl)-4- ((2-(6-methyl-2-(p-tolyl) imidazo [1,2-a]pyridin-3-yl) acetamido) methyl) benzamide are possessing high anti-inflammatory activity against standard drug Aspirin. A majority of the tested compounds had shown good consequence to moderate anti-inflammatory...
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Posted by admin on Feb 28, 2019 in |
The present study involves the formulation and in-vitro characterization of sustained release matrix tablets of Ambroxol hydrochloride, a potent mucolytic agent used in the treatment of respiratory disorders. FTIR analysis confirmed the absence of drug-polymer interactions. Sustained release matrix tablets containing 75 mg were formulated employing HPMCK15 and xanthan gum as release retarding polymer and dicalcium phosphate and microcrystalline cellulose as diluents. The powder blend was evaluated for micromeritic properties. The matrix tablets were prepared by direct compression technique. The prepared tablets were evaluated for uniformity of weight, hardness, friability, and uniformity of content. All the formulations showed compliance with pharmacopoeial standards. The in-vitro drug release studies were carried out for a period of 12 h using USP type II dissolution apparatus at 50 rpm by taking 900 ml of 0.1 N HCl (pH 1.2) as dissolution medium for first 2 h and later replacing it with 900 ml pH 6.8 phosphate buffer solution for a period of 10 h at 37 ± 0.5 °C. Among the different combinations...
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Posted by admin on Feb 28, 2019 in |
The formulation and evaluation of toothpaste contain Aloe vera along with the combination of sodium chloride. Aloe vera shows a number of uses either internally or externally, and the number of uses also increases as the research going on. In this formulation, we tried to find out the antimicrobial activity of Aloe vera in toothpaste formulation, for the said purpose we use S. aureus culture. After designing the batches in software Design Expert® 10, the batches were formulated and evaluated. At the end of work, we found that the prepared toothpaste shows considerable zone of inhibition which concludes its antimicrobial activity. The formulation also shows sufficient foaming power for its cleansing action. The observed results were found to significant concerning the chosen cubic model in software Design Expert® 10. Thus from the collected results, we concluded that the toothpaste containing a combination of Aloe and sodium chloride possesses antimicrobial activity, but for its practical use its necessary to determine its effect on oral cavities and probable side effects after...
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Posted by admin on Feb 28, 2019 in |
The active ingredient flavonoids especially Flavones, e.g., Quercetin was identified from the methanol extract of Alpinia officinarum. This study evaluates the antidepressant activity of Alpinia officinarum (L.) wild Hance (Zingiberaceae) in Swiss Albino mice models. The antidepressant activity was evaluated by using different animal models viz. tail suspension test, despair swim test, potentiation of norepinephrine toxicity test, 5-hydroxytryptophan potentiation in Swiss Albino mice. The methanol extract of Alpinia officinarum significantly increases Na+, K+-ATPase level in the brain in the tail suspension test model. An antidepressant effect in the despair swim test was confirmed by the increase in monoamines (NE, DA, 5HT) and γ-aminobutyric acid levels in the brain. Alpinia officinarum methanol extract also contributes to the normal regulation of the HPA axis by significant (P<0.001) decreased in plasma corticosterone level. Alpinia officinarum (400 mg/kg) showed antidepressant potential by increasing the number of head twitches induced by 5 HTP. Antidepressant effect of an extract of Alpinia officinarum at a dose of 400 mg/kg could be via modulation of brain monoamines...
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