Posted by admin on Feb 28, 2019 in |
The antidiabetic and anti-inflammatory effects of probiotic Lactobacillus fermentum MCC3216 was investigated in high fructose-fed type 2 diabetic rats. Type 2 diabetes was induced by feeding high fructose diet to male albino Wistar rats. A single daily dose of 2 × 108 CFU/ml of L. fermentum MCC3216 was given to Wistar rats for 8 weeks. The fasting blood glucose, body weight, oral glucose tolerance test, glycosylated hemoglobin, insulin, liver glycogen, lipid profile, and oxidative stress parameters were measured. The level of Interleukin-6 and Interleukin-10 were also measured in serum. Histopathology analysis of pancreas and liver injury were performed. At 8 week L. fermentum MCC3216 significantly (P<0.05) decrease FBG, body weight, glucose intolerance, HbA1c, insulin, liver glycogen, total cholesterol, triacylglycerol, LDL-C, VLDL-C, lipid peroxidation and IL-6 level as compared to diabetic rats. The values for HDL-C, reduced glutathione, superoxide dismutase, catalase and IL-10 were significantly (P<0.05) increased in L. fermentum MCC3216 treated group as compared to diabetic rats. Islets of Langerhans and hepatic cells in L. fermentum MCC3216 treated group...
Read More
Posted by admin on Feb 28, 2019 in |
A floating controlled drug delivery system of loratadine was formulated to enhance the retention time in the stomach and to modify the release characteristics of loratadine. Loratadine loaded floating gel beads were prepared by ionic gelation technique using different polymers such as HPMC K4M, HPMC K15M, and carbopol 934P in different proportions and sodium bicarbonate as the gas forming agent. FT-IR spectra revealed that there was no significant interaction of loratadine with the carriers and other excipients. The prepared beads were evaluated for particle size analysis, bulk density, tapped density, compressibility index, hausner’s ratio, the angle of repose, swelling index, drug entrapment efficiency, % yield, % buoyancy of loratadine floating beads, in-vitro drug release studies, kinetic modeling of drug release and stability studies. Results of the in-vitro drug release study indicated sustained release of loratadine for up to 12 h. The drug release kinetics of optimized formulation F7 was best fitted with the zero order and Peppas model with...
Read More
Posted by admin on Feb 28, 2019 in |
The plant Ficus racemosa L., is a woody large deciduous tree distributed all over India, and grows in the evergreen forest, moist localities, along with the sides of ravines and banks of streams belonging to the family Moraceae, locally know as Attimara and Hindi known as Gular. Ethnobotanically the bark used for anti-diabetic, wounds, useful in asthma and piles recommended in uropathy and treatment of menorrhagia. Biological activities like anti-inflammatory, anti-diarrhea, anti-diuretic, antibacterial, hepatoprotective, were reported. The present study finds outs the scientifical evidence of bark of Ficus racemosa L. for its antioxidant property using different screening models. The different extract of bark was obtained by successive extraction with petroleum ether (40-60 ºC), butanol, ethyl acetate, alcohol by Soxhlet method. These extracts were taken for an in-vitro antioxidant study, were carried out by using in-vitro antioxidant screening models like DPPH radical scavenging activity and total phenolic contents (TPC). The few successive plant extracts showed significant dose-dependent activity by using various in-vitro antioxidant models. Antioxidant activity of bark showed a...
Read More
Posted by admin on Feb 28, 2019 in |
Spilanthes acmella (SA) commonly known as “Akarkara” frequently available in most of the areas of India, Sri Lanka, Bangladesh, China, Japan, and Thailand; is well reputed in the indigenous system of medicine for its medicinal use in toothache and rheumatic fever. The present study was aimed to evaluate its traditional use in liver diseases using the in-vivo model of rabbits. The Spilanthes acmella extract (SAE) based gel was investigated for its hepatocurative activities in Paracetamol intoxicated (2 g/kg) rabbits. Rabbits were divided into three groups, normal control (saline-treated) hepatotoxic control (Paracetamol treated) and remaining one was hepatotoxic treated with the SAE -based gel (400 mg/kg) for 7-14 days. One serving as control another as hepatotoxic and last one as treated with Paracetamol and then SAE-based gel Group 2nd and 3rd were intoxicated with Paracetamol. After the 3rd day of the treatment with Paracetamol, increased serum transaminases (sGOT and sGPT) and alkaline phosphatase (ALP) levels were observed. In the case of hepatocuration of SAE -based gel caused a significant reduction...
Read More
Posted by admin on Feb 28, 2019 in |
In recent years metallic nanoparticles, represent one of the most comprehensively studied materials because of their application in biology The synthesis of silver nanoparticles using biological entities has received immense attention in the area of research. Medicinal plants have attracted interest over antibiotics due to a rapid increase in the rate of infections, development of antibiotic resistance in microorganisms and side effects of antibiotics. In the present study biosynthesis of silver nanoparticles was performed using Syzygium cumini. Spectrochemical studies indicate the surface plasmon resonance band and the presence of a capping agent responsible for the synthesis of AgNPs. The results revealed that S. cumini along with synthesized AgNP found to possess microbicidal effect. 400 µl of synthesized AgNP was found to be resistant against Bacillus sp. (23 mm), followed by S. epidermis and A. niger (22.5 mm). HPLC chromatogram reveals the presence of flavonoids such as quercetin and myricetin responsible for...
Read More
