Posted by admin on Nov 30, 2018 in |
Synthetic organic compounds, containing relatively higher number of nitrogen attracting interest in the current medical research due to their utility in chemotherapy. The development of new medicines with more number of nitrogen atoms in their structural framework is an important challenging task for medicinal chemists. The lipophilicity of Mannich bases and their metal complexes enables them to be more potent novel medicines and acquire huge interest among medicinal chemists. We report here the synthesis of novel lead structure of new Mannich base and its complexeswith the variety of transition metals such as Co(II), Mn(II), Ni(II), Cu(II) and Zn(II) and evaluated them for DPPH free radical scavenging and anti-inflammatory activity. As the Mannich base from the combinations 4-nitrobenzaldehyde, morpholine and nicotinamide was not yet reported, the new Mannich base, N-[Morpholino(4-nitrophenyl)methyl]nicotinamide (NMN), was synthesized from this combination. The ligand and its complexes were characterized using various analytical (Chemical assays, Elemental analysis and TLC) and spectral studies (FT-IR, UV-Visible, 1H NMR, 13C NMR, Mass and...
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Posted by admin on Nov 30, 2018 in |
Infectious bronchitis virus causes infectious bronchitis in chickens. Variant 2 is a virulent strain circulating in the Middle East, Iraq is one of them, which harbor the strain at high rate causes a severe economic loos. Sequences of variable S1 glycoprotein were collected, consensus sequence derived and used in computational epitope vaccine design. The results gave one B cell epitope “DFMYGSYHPKCDFRPETIN” with very high antigenic score. T cell (CTL) epitope prediction produced four epitopes “QTQTAQSGY, FNFSFLSSF, FSFLSSFVY, NSLSVSLAY” with desirable criteria and react with many MHC I alleles, and docked with BF2*21:01 and BF2.0401 chicken MHC I molecules. T helper cell epitopes prediction gave eight epitopes “GYYNFNFSFLSSFVY, KFIVYRETSVNTTLV, LTNFTFTNVSNALPN, TG GVNTINIYQTQTA, TINIYQTQTAQSGYY, YNFNFSFLSSFVYKQ, NNGL WFNSLSVSLAY, NGLWFNSLSVSLAYG” reacting with many MHC II alleles. These epitopes can be used for preparation of vaccine to be investigated in wet lab...
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Posted by admin on Nov 30, 2018 in |
TAT (Trans-activator-Transcription Protein) is a viral protein encoded by the TAT gene in HIV-1-which is a lethal subtype of HIV (Human immunodeficiency Virus). It is vital for transcription of the viral genome. Previous studies show that in Human, TAT is a toxin-producing protein allowing cell death in obtained from QSAR studies, best quassinoid compounds were used to find the highest binding affinity compound by performing normal T-cells. Thereafter allows for progression towards AIDS (Acquired immunodeficiency syndrome). Traditionally, herbal medicines have played a vital role in the treatment of many diseases and ailments. Likewise, Quassinoids from the plant family Simaroubacaea, possess insecticidal, antimalarial and anticancer properties. Although studies have been conducted to find anti-HIV activities against other HIV-1 proteins, there are no traces of studies against Trans-activator-Transcription protein (1JFW). The main objective of this study is to find an efficacious inhibitor against a synthetic HIV TAT protein (PDB- IJFW). After a thorough literature survey, the molecular and biological activity of quassinoid phytoconstituents has been recorded for QSAR (Quantitative structure-activity relationship)...
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Posted by admin on Nov 30, 2018 in |
Background: Lung Cancer is the commonly diagnosed neoplasm in males in India. The main histological types of lung cancer are squamous cell carcinoma, adenocarcinoma, small cell carcinoma and large cell carcinoma. However, histological types may vary with the changes in geographical region, smoking status and other social factors. This study aimed to find out the relationship of smoking and histological types of lung cancer. Methods: We performed a prospective observational analysis of 238 histopathologically proven cases of lung cancer in Malappuram district of Kerala during the period of 2017 and 2018. Results: A total of 238 patients involved, 82.77% were males and the male to female ratio was 4.8:1. Of the 238 patients, 166 patients (69.75%) had history of smoking in their life time and 72 patients (30.25%) were non-smokers. In males, majority of patients were smokers (83.25%) and in female patients, 39 (95.12%) were non-smokers. Among Smokers, squamous cell carcinoma (63.25%) is the most common histological type followed by adenocarcinoma (22.89%). In case of non-smokers, the status is...
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Posted by admin on Nov 30, 2018 in |
Sufoof – e -Hazim (SEH), Unani formulation with high therapeutic efficacy, has been reported to cure indigestion and flatulence. The formulation is available with different manufacturers but scientific data on its pharmacognosy is lacking. Hence, the current research work is an attempt to standardize the formulation and establish quality control parameters in terms of its phytochemical and chromatographic evaluation. SEH was prepared as per National Formulary of Unani Medicine (NFUM). As a rapid method for detection of adulteration, powder microscopy was carried out for the formulation along with its individual ingredients in order to locate persistant and discernable characters belonging to the individual ingredients from the formulation. Phytochemical evaluation was carried out along with estimation of reducing sugars and crude fibre content in the formulation. Further, a simple, rapid, accurate and sensitive HPTLC method was developed for the simultaneous estimation of pharmacologically active markers, betasitosterol and lupeol. The method was validated as per ICH guidelines for the parameters such as linearity, intra and interday precision, accuracy, recovery etc. The...
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