Posted by admin on Oct 31, 2018 in |
Currently, coronary artery disease is reported as the major cause of mortality and morbidity and is expected to be the reason for 40% death in 2020. Since its rate is high in type 2 diabetes mellitus patients, a study has been designed to analyze the correlation of insulin resistance and obesity with incidence and severity of disease. Study was done on 109 individuals with established CAD in the age group of 40 – 70 years who had undergone coronary angiography and diagnosed with coronary artery disease including single vessel, double vessel and triple vessel and seventy one healthy individuals matched for age, and sex. The estimation of fasting FBG), post prandial blood glucose (PPBG, fasting insulin and insulin resistance by gold standard methods. In our study BMI and insulin resistance was found to be significantly high in CAD with diabetes mellitus subjects compared to CAD without DM and control (with p<0.001). Also in our study significantly high percentage of incidence of CAD and significantly high level of severity in...
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Posted by admin on Oct 31, 2018 in |
Neurodegeneration is a powerful initiator for a number of nervous system related diseases that come under the term “neurodegenerative diseases”. Neurodegenerative diseases are incurable, results in the progressive degeneration of nerve cells and causes problems with movement and mental functioning that became a challenge in present day’s health care. For this study we made a model of Huntington’s chorea, one of the neurodegenerative disorders by inducing experimental neurodegeneration and tried to prevent the neurodegeneration by giving ethanolic extract of Withania somnifera and its active principle withanolide A 10 days before the lesion surgery. The herb Withania somnifera is a well known herb in India and was used by all the Ayurvedic legends for nervous system related problems. We used 5 animal groups for this study they are CO, SC, LC, WS125 and WA100. All the animals were trained to walk in a narrow beam prior to surgery and were analyzed for motor co-ordination on the 5th day post lesion to find out the protective nature of the drugs employed....
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Posted by admin on Oct 31, 2018 in |
Plants are an important source of substances which are claimed to induce biological activities. Although there are a few studies on antimicrobial and antioxidant activities of this plant, antimutagenic activity has not been studied and there is no study in Turkey. Antibacterial activities of Syzygium aromaticum against oral pathogens have not been reported until today. The scope of this work was to investigate the biological activities of S. aromaticum different extracts. The various extracts were screened for antibacterial activity. The bacteria were isolated from oral flora by traditional methods. The plant extracts were tested by Kirby-Bauer method. Other antibacterial activities tests are MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration). In addition to, the antioxidant activities of plant extracts were screened by the stable DPPH (2, 2-diphenyl- 1-picrylhydrazyl hydrate) free-radical. The antimutagenicity of the plant extracts were determined by Ames test using Salmonella typimurium strains. The highest antibacterial activity was determined as 20 mm inhibition zone from methanol extracts. The highest DPPH scavenging activity was found as 82%...
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Posted by admin on Oct 31, 2018 in |
Chromatographic method was developed according to Quality by Design (QbD) approach as per ICH Q8 (R2) guidelines for estimation of pitavastatin in pharmaceutical dosage form. By considering the current regulatory requirement for an analytical method development, a reversed phase high performance liquid chromatographic method for routine analysis of Pitavastatin has been optimized using analytical quality by design approach. Unlike routine approach, the present study was initiated with understanding of quality target product profile, analytical target profile and risk assessment for method variables that affect the method response. A liquid chromatography system equipped with a C18 column (250 × 4.6 mm, 5 µ), a binary pump and photodiode array detector were used in this work. The experiments were conducted based on plan by central composite design, which could save time, reagents and other resources. Sigma Tech software was used to plan and analyses the experimental observations and obtain quadratic process model. The process model was used for predictive solution for retention time. The predicted data from contour diagram for retention...
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Posted by admin on Oct 31, 2018 in |
Fruits play an important role in human life because it provides valuable nutrients such as carbohydrates protein and fibres. Fruits are commercially processed to produce fruit juices, jams, jellies etc. Fruit juices sometime naturally contaminates with certain substances like carbohydrates, heavy metals etc. However, sometime manufacturer intentionally adds some substance like carbohydrates and acids to increase the life span of the products and vitamin C to increase product sale. Presence of carbohydrates and acid helps in the quality assessment of the fruit juices. Color tests mainly used for the identification of carbohydrates such as sugar, reducing sugar and invert sugar etc. Titration is a common laboratory method of quantitative/chemical analysis that can be used to determine the unknown concentration of a known reactant. In the present study, total six branded mango juice samples were collected from local market of Gandhinagar. Acid content, fruit content, reducing sugar, total reducing sugar and glucose: fructose ratio and vitamin C were analysed with titrimetric method and this were found in the range of...
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