Posted by admin on Dec 31, 2018 in |
Currently, nutrition and health linkages focused on the emerging strategy of diet based regimen to combat various physiological threats including cardiovascular disorders, oxidative stress, diabetes mellitus, etc. Berry / Fruit part of Diospyros kaki Linn. was extracted using petroleum ether, chloroform, ethanol consecutively and the obtained extracts were screened for hepatoprotective activity using CCl4 induced liver damage model. The activity was assessed by comparing the serum enzyme levels such as serum glutamate pyruvate transaminase, serum glutamate oxalate transaminase, total bilirubin, alkaline phosphatase of fruit extracts treated group with carbon tetrachloride treated animals and results showed dose-dependent activity, ethanolic extract treated group showed highly significant activity, whereas chloroform extract treated group has shown the significant action but less compare to ethanolic extract, petroleum ether treated group showed moderate action and petroleum ether extract at a dose of 100 mg/kg b.w showed least significant action. The results were further supported by histopathological...
Read More
Posted by admin on Dec 31, 2018 in |
Diabetes is a non-communicable disease characterized by increased blood glucose. As regular monitoring of glucose and glycated hemoglobin (HbA1c) levels in diabetic individual’s blood causes psychological stress, development of a non-invasive technique to quantify glucose and HbA1c are essential. This study was carried out to compare and correlate the blood and salivary glucose and blood HbA1c levels in diabetic individuals. Results showed that mean blood and saliva glucose levels were higher in the uncontrolled diabetic group than controlled diabetic and control groups. Blood HbA1c level was also elevated in uncontrolled type-2 diabetes (T2D) group, followed by controlled diabetic and control groups. A significant difference was noticed between the blood and saliva glucose levels of control and uncontrolled T2D groups. Further, the difference in serum HbA1C levels between control, controlled T2D, and uncontrolled T2D groups was also significant. Taken together, these results explicated the use of saliva as a non-invasive, painless technique in the management of T2D...
Read More
Posted by admin on Dec 31, 2018 in |
The increasing incidence of MDR and XDR tuberculosis worldwide highlight the urgent need to search for newer anti-tuberculosis molecules. This research article presents a phytochemical study and antitubercular potential of methanol: water (MW), ethanol: water (EW) and dichloromethane: methanol (DM) of extracts of Dendrophthoe falcata (L.) and Tridax procumbens (L.) tested against of H37Rv Mycobacterium tuberculosis using microplate alamar blue assay (MABA) method. Preliminary phytochemicals studies and HPTLC fingerprint analysis revealed the presence of phytochemical like alkaloids, flavonoids, saponins, tannins, a phenolic group, glycosides, terpenoids with different Rf values. Fractions of active extracts analyzed by GC-MS shows a finding of probable phytoconstituents. Findings are useful to establishing standards for identification, purity, quality of the plant. The ethanol: water and methanol: water extracts of Tridax procumbens and D. falcata exhibited significant anti-tuberculosis activity with the MIC values of 0.8 μg/ml, 6.25 μg/ml compared to standard drug Pyrazinamide, Ciprofloxacin and Streptomycin with the MIC values of 3.125 μg/ml 6.25 μg/ml using MABA respectively against Mycobacterium tuberculosis (H37Rv strain) ATCC no.-27294. The...
Read More
Posted by admin on Dec 31, 2018 in |
Prostaglandin endoperoxide synthases, usually known as cyclooxygenases (cyclooxygenase-1 and cyclooxygenase-2), catalyze a key step in the formation of biologically effective prostaglandins. In recent times, a cyclooxygenase-1 variant protein, called cyclooxygenase-3 used to be found and characterized. COX-3 is studied recent along with significant margin for the formation of anti-inflammatory, analgesic and anticancer agents. In a pharmaceutical area, various drugs targeted on this enzyme are Acetaminophen, Dipyrone, Antipyrine, Dimethylaminopyrene, Diclofenac, Aspirin, Ibuprofen, Thalidomide and Caffeine. It is a new era for COX family that contains numerous significant applications that’s the reason it is the center of attraction for researchers. Currently, the role of COX-3 in human is unclear, but scientists continue to do work in this area. The objectives of this review article are to gather all newest data literature related to developments in the structural and biochemical features of the cyclooxygenase-3 isoenzyme along with discussing its application for the various pharmacological effects of...
Read More
Posted by admin on Dec 31, 2018 in |
The study was designed to evaluate the louscidal, and acaricidal activities of alkaloids of Calpurnia aurea leaves extracts. Alkaloid of C. area leaves extract at concentrations of 200, 100, 50, 25, 12.5 and 6.25 mg/ml were used for in-vitro adult immersion test of ticks and lice, which they were monitored for their mortality rates for 24 h. The activities of test substances were evaluated against Amblyomma variegatum and Linognathus ovillus, and compared with diazinon 60 EC. After 24 h post exposure, two higher concentrations of 200 and 100 mg/ml of the alkaloid extract caused 100 ± 0.5% and 100 ± 0.6% lice mortality, and 100 ± 0.33 and 93.3 ± 0.33 tick mortality respectively. The alkaloid extract showed an insignificant difference in its acaricidal and louscidal activity when compared to the Diazinon 60EC at the same concentration (P>0.05). LC50 and LC90 values (with 95% confidence limits) of the alkaloid of C. aurea for lice and tick were estimated 9.08 mg/ml (6.21-13.47), 17.65 mg/ml (11.71-22.49) and mg/ml 16.69 (11.77, 26.64),...
Read More
