Posted by admin on Oct 31, 2018 in |
Chemotherapy and radiation are the most prescribed methods of cancer treatments but these are highly toxic and also are carcinogenic thus alternative cures are being explored especially on the use of cytotoxic substances isolated from natural sources like plants known for their ethnomedicinal properties. Natural chemopreventive agents such as antioxidants isolated from plants are argued to be important in suppressing or reversing carcinogenesis and to prevent the development of invasive cancers thus research studies are now currently geared in the evaluation and determination of the cytotoxicity and antioxidant activity of plant extracts to serve as ideal cure. Since the acquisition and processing of highly cytotoxic and selective effects of plant-based compounds to cancer cells are still limited, this study was conducted on eight plant species known to have folkloric medicinal properties. The leaf ethanolic extracts were examined for their antioxidant properties and cytotoxicity against Human Non-Small Cell Lung adenocarcinoma (A549), Human Colon Carcinoma Cells (HCT116) and Chinese Hamster Normal Ovary Cells (AA8). Antioxidant properties were observed to be high...
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Posted by admin on Oct 31, 2018 in |
The purpose of present study was to formulate the gastro-retentive floating microspheres of atazanavir sulfate to be retentive in the stomach for prolonged period of time. The gastro-retentive floating microspheres were prepared by double emulsion w1/o/w2 solvent evaporation technique and characterization for particle size, SEM, floating time, FTIR, DSC, and entrapment efficiency. The in-vitro drug release studies and in-vitro drug kinetics were performed for different formulations. FTIR and DSC studies revealed that the drug is compatible with excipients. The floating time of the floating microspheres was found to be > 12h. The particle size of all the formulations was evaluated by optical microscopy method. Formulation F1 – F4 comprising HPMC as rate retarding polymer exhibits an average particle size of about 515.25µm and microspheres F5 – F8 prepared with eudragit exhibit a mean particle of about 611.4 µm. Eudragit formulations exhibit an increased entrapment efficiency which is due to its large particle size and increased viscosity. All batches prepared show an initial burst release followed by sustained release. Formulation...
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Posted by admin on Oct 31, 2018 in |
Background: WHO statistics for 2015 give an estimated incidence figure of 2.2 million cases of TB for India out of a global incidence of 9 million thus making India accountable for almost one-third of the global TB burden. The first-line antitubercular drugs include H (Isoniazid), R (Rifampicin), Z (Pyrazinamide), E (Ethambutol) and S (Streptomycin). The treatment of tuberculosis being of longer duration being a multidrug regime and of longer duration gets associated with various adverse effects. Objective: The study aimed to determine the incidence and pattern of adverse drug reactions (ADRs) of anti-tubercular drugs in tuberculosis patients treated under DOTS at tertiary care hospital of Northern India. Material and Method: A total of 115 patients were monitored for the period of 12 months. The diagnosis of tuberculosis was confirmed by sputum smear prior to enrolment. Before the patients were started on DOTS regimen, they were submitted to some pretreatment investigation and then they have been followed up to look for any adverse effects which have been recorded onto the...
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Posted by admin on Oct 31, 2018 in |
A series of N-mustard substituted coumarin have been synthesized characterized and evaluated for their in-vitro cytotoxicity and anticancer activity against PC-3 human cancer cell lines. The methodology involves nucleophilic substitution of readily accessible 3-cyano-4-chloro coumarin with ethanol amine further on chlorination gives substituted 4-(bis(2-chloroethyl)amino)-2-oxo-2H-chromene-3-carbonitrile derivatives. Among these compounds screened, three compounds (ASW-3g, ASW-3f and ASW-3e) showed GI50 range from 80 to 95 µg/ml. All synthesized compounds were characterized by IR, NMR and Mass spectral analysis and screened for anticancer activity using PC-3 cell line. All the compounds showed moderate to good anticancer...
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Posted by admin on Sep 30, 2018 in |
This study was planned to evaluate the anti-inflammatory effect of roots of Asparagus curillus in periodontal inflammation via assessing gingival crevicular fluid (GCF) and salivary inflammatory markers namely MMP-8, -9, 13, TIMP-1 and IL-6. Samples of GCF and saliva were obtained from patients with chronic periodontitis (n = 98) and healthy controls (n = 27). Study population (n = 98) was divided into two groups – Group A: patients with periodontitis receiving only conservative periodontal treatment and Group B: patients with periodontitis receiving both the conservative periodontal treatment and Ayurvedic therapy in combination. Concentrations of periodontal inflammatory markers i.e. MMP-8, -9,-13, TIMP-1 and IL-6 were estimated by Enzyme linked immuno absorbent assay and were analysed at two different time intervals i.e. at baseline and 3 months after therapy. There was statistically significant decrease in the concentrations of MMP-8, -9, -13 in GCF and saliva in both the groups at 3 months after therapy. (p < 0.05) However, there was found a statistically significant lower concentration of the markers in...
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