Posted by admin on Nov 30, 2018 in |
Background: Medical Intensive Care Unit (ICU) can be a potential place for Pharmacovigilance due to high frequency of Adverse Drug Reactions (ADRs). Regular evaluation can help in understanding the pattern of ADR and reduce the incidence of it. Aims and Objectives: To evaluate incidence of ADRs in patients receiving various modes of treatment at medical ICU of our tertiary care hospital and classify them. Materials and Methods: Study was carried out by actively observing 500 patients admitted at medical ICU over a period of 18 months. Suspected ADRs were reported and classified. Association between various factors was carried out by chi square test. Results: Total 59 (11.8%) ADRs were reported. Most common was hypotension 8 (13.56%) followed by headache 7 (11.86%). Highest group responsible for ADRs was fibrinolytic drugs 14 (23.73%). Coagulation and cardiovascular systems were commonest to involve with incidence rate of 16 (27.12%) and 14 (23.73%) respectively. Commonest type was A with incidence rate of 42 (71.19%). Significant association was noted between no. of drugs and increased...
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Posted by admin on Nov 30, 2018 in |
Rosa damascena Mill. also known as Damask rose, Persian rose or Gul-e-Muhammadi of Rosaceae family is an aromatic small plant cultivated all over the world for its visual beauty, fragrances and therapeutic potential. The plant is rich in tannins, flavonoids, glycosides, carboxylic acids and ascorbic acid. In addition to its aromatic properties, the plant possesses laxative, anti-oxidant, anti-bacterial, wound healing, skin health, cardiotonic, hypnotic and cough suppressant activities. The medicinal uses reported from this plant are of its methanolic, ethanolic or chloroformic extract and of its essential oil. This research is planned to investigate the analgesic and anti-inflammatory potential of aqua distillate of Rosa damascena Mill. flower in two different doses i.e. 250 mg/kg and 500 mg/kg using Hot Plate, Tail Flick and acetic acid induced paw-edema method. Also as recent studies reported that alcoholic extract of Rosa damascena possesses analgesic activity and aqueous extract does not, so this study also aimed to evaluate these activities after its distillation in aqueous...
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Posted by admin on Nov 30, 2018 in |
Type 2 diabetes is a chronic metabolic disease that has a significant impact on the health, quality of life, and life expectancy of patients, as well as on the health care system. Exercise, diet, and weight control continue to be essential and effective means of improving glucose homeostasis. Despite considerable progress in the treatment of diabetes by oral hypoglycemic agents, search for newer drugs continues because the existing synthetic drugs have several limitations. The herbal drugs with antidiabetic activity are yet to be commercially formulated as modern medicines, even though they have been acclaimed for their therapeutic properties in the traditional systems of medicine. The present study concise on the effect of a compound ethanolic extract of all three plant parts as leaf extract of Annona squamosa, leaf extract of Eclipta alba and leaf extract of Butea monosperma, on fasting blood sugar levels and serum biochemical analysis in alloxan-induced diabetic rats were investigated. All the concentration of compound extracts produced a significant antidiabetic activity at dose levels 1/5 of...
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Posted by admin on Nov 30, 2018 in |
Polycystic ovary syndrome (PCOS) is one of the most common disorders that occur in women at any age due to the endocrine hormone imbalance. The cause for this disorder is still not identified, but on recent research provided that disorder may be caused by some genetic variation. Predicting and understanding the effects of genetic variation that occurred in the gene are becoming more important for single nucleotide polymorphism to understand the molecular basis of genetic disease. From the literature survey, the candidate gene which is responsible for causing genetic PCOS was identified. In this work using computational methods, this candidate gene was analyzed completely to find out the genetic variation which in charge for altering the expression and the functional of the gene. On analyzing the gene, it was predicted that the protein which was translated from the gene played a key role for causing the major alteration in the gene. Using SNP analysis tool, further investigation were carried out to the disease causing protein and were predicted that...
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Posted by admin on Oct 31, 2018 in |
Involvements of oxidative damage, deficiency of acetylcholine and cognitive impairment have been reported in the pathophysiology of epilepsy. It has been demonstrated that cholinesterase is degranulated at the site of a lesion it cause brain disorder leading to epilepsy. Cholinesterase inhibitor (Galantamine) inhibits the release of cholinesterase thus it benefits in epilepsy. So the aim of the study was to evaluate both effect cholinesterase inhibitor (Galantamine) and cognitive behaviour in epilepsy induced by increasing current electroshock seizures test of Wistar rats. Epilepsy was evaluated by behavioural tests such as spontaneous alternation behaviour and Rota rod test. Measurement of oxidative stress was done by various biochemical estimations namely lipid peroxides (in brain), protein estimation using Folin’s reagent and brain reduced glutathione estimation. All the results of galantamine (0.5 mg/kg & 1 mg/kg) were compared to the standard drug sodium valporate (100 mg/kg & 200...
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