Posted by admin on Aug 31, 2018 in |
Free radicals are molecules with an unpaired electron that very unstable and react quickly with other compound to gain stability. Once the process is started, it can be a cascade reaction resulting disruption of a living cell. The free radicals formed in our body are combated by antioxidants then interact with free radicals and terminate the chain reaction before vital molecules are damaged. Moringa oleifera leaf extract well known can be as a source of antioxidant since it contains flavanoids for reducing free radical. This study was design to produce a crude extract of dark green and bright green of M. oleifera leaves using different solvent to determine its antiaging effect in male mice Mus musculus Swiss Webster. The antioxidant capacity of the extract were carried out using TMAMQ (Tetramethoxy Azobizmethylene Quinon) and ABTS (2, 2-Azino-bis (3-ethyl-benzothiazoline-6-sulfonic acid) method, while the antiaging activity were assessed by histological approach. The results showed that the highest antioxidant capacity was achieved by dark green M. oleifera leaves ethanolic extract followed by double-destilated...
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Posted by admin on Aug 31, 2018 in |
Natural drugs are boom to mankind. They have few side effects as compared to allopathic medicines. Psidium guajava, is an important food crop and medicinal plant in tropical and subtropical countries is widely used like food and in folk medicine around of the world. Psidium guajava linked with the antioxidant, hepatoprotective, anti-allergy, antimicrobial, antigenotoxic, antiplasmodial, cytotoxic, antispasmodic, cardio active, anti-cough, antidiabetic, anti-inflammatory and anti-nociceptive activities and also used as hypoglycemic agent. Decoction of the bark used for diarrhoea and fever of Manilkara zapota. It contains linoleic acid, oleic acid, unsaturated fatty acids, linoleic acid, tannins, flavonoids. Crude extract of Manilkara zapota and Psidium guajava showed anti-microbial activity against gram positive Bacillus subtilis, Staphylococcus aureus and gram negative Escherichia coli, Salmonella typhii. The alcoholic fractions of leaves of Psidium guajava and Manilkara zapota were taken. The concentrations of leaf extract are made and evaluated for antimicrobial activity. DMSO is used as standard for antimicrobial assay. Highest zone of inhibition seen on the concentration of (0:2) and (0.4:1.6 ) for all...
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Posted by admin on Aug 31, 2018 in |
Paneer has great value in diet because it is a rich source of high quality proteins, fat, and minerals. Paneer has a short life span of 2-3 days of refrigeration storage, but freshness of the product is lost after one day. So, the present study was carried out to know the quality of different brands of paneer sold in Delhi City. A total of 80 packets of eight different brands were analyzed for their quality. Wide variation in chemical composition like moisture (49% to 64%), fat (13.5% to 24%), protein (18% to 23%) and lactose (1.75% to 4.23%) existed in the samples. Total bacterial count was observed between 25.40 and 41.10 × 104/gm, yeast and mold count was observed to be 13.75 and 20.90 × 101/gm, coli-form count was 3.95 to 7.65 × 101/gm and Staphylococcus aureus count was 1.10 to 2.20 × 101/gm. Instrumental hardness value varied between 27.56 and 62.22 N. About 75% of the brands did not conform to Food Safety and Standards Authority of India...
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Posted by admin on Aug 31, 2018 in |
The objectives of the present study were to use design of experiments (DOE) for formulation and optimization liposomal formulations and study the impact of process variables on quality attributes of the complex liposomal formulation system. Several factors may have contributed to the slow pace of commercialization of liposome drug products during the last decade: 1) the difficulties associated with identifying the formulation and process design critical quality attributes of these complex systems and 2) Higher manufacturing cost due to low preparation reproducibility and low entrapment of therapeutic active agents. Thus, a central composite design (CCD) was used for the optimization of the liposomal formulation. In the present study, the hydration volume, hydration time, sonication time and drug: lecithin ratio were chosen as input variables for the liposomal preparation and whereas; like particle size, peak shape, polydispersity Index, drug loading, entrapment efficiency and redispersion behavior were investigated as quality attributes. Additionally, contour plots and response surface plots were also utilized to understand the fundamental relationships between input variables and quality...
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Posted by admin on Aug 31, 2018 in |
Statins exhibit their pharmalogical effects by competitive inhibition trough binding with active sites of enzymes. Rosuvastatin, of all statines, has the most binding interactions with the enzyme, and being the most potent statin, it is presumed that the strength of enzyme binding directly influences its potency. Reduction of derivatives of mevalonic acids results with decreased risk of cardiovascular diseases and very significant pleotropic effect of statins. Rosuvastatin comes in the form of calcium salt. During the clinical trial it has been marked as superstatin with its proven activity in lowering cholesterol levels. Aim of this paper was to examine the pleotropic properties of rosuvastatin trough investigate if rosuvastatin shows antihyperalgesic / antiedemic effects by inflammatory pain model in rats trough effects of systemically applied rosuvastatin in inflammatory pain model in rats and effects of locally, peripherally applied rosuvastatin in inflammatory pain model in...
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