Posted by admin on Sep 30, 2018 in |
The aspiration of the coeval cramming is connate with the entirety of second generation Super Porous Hydrogel Composites (SPHCs) with polyvinyl alcohol as a melded material. Conglomerates were unified by proving gas fanning approach. For coalescence, 50% Acrylamide solution (AM) and 50% Acrylic Acid solution (AA) were used as a monomer, 2.5% N, N’-methylene bisacrylamide (BIS) as a cross linker, 20% Ammonium Per Sulphate (APS) and 20% N, N, N’, N’- Tetramethylethylene Diamine (TEMED) as a polymerization assailant pair, 10% span 80 as a foam stabilizer were used. The gaffed super porous hydrogel’s were peg by inchoate enormity, computation of plausible density, porosity, bunion studies, void fraction, mechanical strength and surface morphology muse. In bifold distilled water, SPHCs trot out appalling accretion in their stasis bunion capacity. PVA revamp the bruise characteristics in twain the swelling media. SPHCs disport enriched mechanical clout as the concentration of polyvinyl alcohol is elevated. SEM images precisely marked the formation of interconnected pore, capillary channels, and the cross-linked polyvinyl alcohol molecules were espied...
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Posted by admin on Sep 30, 2018 in |
The present study assayed the antifungal, larvicidal and antioxidant properties of the aqueous and acetone extracts of root and shoot of Biophytum sensitivum (Linn.) DC. The aqueous extracts of both root and shoot had little activity against the three test fungi such as A. niger, A. flavus and Penicillium. The acetone shoot extract was also ineffective against these fungi. However, the acetone root extract exhibited magnificent antifungal activity against A. flavus (zone of growth inhibition of 33.5 mm); but moderately affected the growth of Penicillium (9.5 mm), in the disc diffusion assay. The acetone root extract had no activity on A. flavus. The aqueous extracts of root and shoot of B. sensitivum were also assayed for larvicidal activity on the the 3rd and 4th instar mosquito larval stages. The shoot extract exhibited potent larvicidal activity, with 100% mortality induced in the larvae, within 48 h of exposure with the extract. The root extract on the contrary, had negligible activity against the mosquito larvae, exhibiting only 30% larvicidal activity, even...
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Posted by admin on Sep 30, 2018 in |
Polymorphonuclear leukocytes or neutrophils are important components of host defense machinery. They are the first line of defense against invading microorganisms. In the present research work, ability of human neutrophils to phagocytose was studied in-vitro by exposing the polymorphonuclear leukocytes to Candida albicans and the phagocytic capacity was evaluated using aqueous extract of leaves powder of Putranjiva roxburghii Wall. The chemotactic activity that is the movement of polymorphonuclear leukocytes towards a chemical stimulant was studied in-vitro by placing polymorphonuclear leukocytes in presence of a chemotactic agent Zymosan using aqueous extract of leaves powder of Putranjiva roxburghii...
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Posted by admin on Sep 30, 2018 in |
Background: Raktachandan / Pterocarpus santalinus is mentioned to have edema reducing property in Ayurvedic literature. Studies have been performed using its methanolic extract for anti-inflammatory, analgesic and antioxidant activities. Since, Ayurveda advises to use it as a decoction, we planned to study the acute anti-inflammatory activity of decoction prepared from Pterocarpus santalinus bark-wood powder. Methodology: Albino rats of either sex were divided into 4 groups of 6 rats each (Group I – Control (CMC-vehicle), Group II – Ibuprofen suspension, Group III – P. santalinus suspension 3.5 mg/kg, Group IV – P. santalinus suspension 7 mg/kg. All the experimental animals were given standard and test drugs orally, 45 min before inducing inflammation. Acute inflammation was induced by injecting 0.1ml of 1% carrageenan solution in sub-plantar tissue of left hind paw of the rats. Paw volume (Plethysmometer) and pain assessment (Randall and Selitto paw withdrawal method) were done at 0 h (before medication), then at 1 h, 2 h, 3 h and 4 h after induction of inflammation. Data was analysed...
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Posted by admin on Sep 30, 2018 in |
Felodipine is a poorly water soluble drug having 15% oral bioavailability. In the present study Self micro emulsifying drug delivery system of felodipine was developed to improve its solubility and bioavailability. SMEDDS were prepared by phase titration method and ternary phase diagram was constructed using Chemix software. Based on solubility of drug in the excipients, capmul MCM, oleic acid, Tween 80 and PEG 400 were selected as oil, surfactant and co-surfactant respectively. Liquid SMEDDS were characterized for self-micro emulsification time, droplet size, poly dispersity index, zeta potential, drug release, ex-vivo permeation. The optimized liquid SMEDDS formulation F16 contained capmul MCM (35%), tween 80 (55%), PEG 400 (10%). Formulation F16 has size of 13.66 nm, zeta potential-25.7 mV, drug release 78% in 8 h. The optimized liquid SMEDDS were converted into solid SMEDDS by adsorbing on to neusilin. The drug release was studied in 0.1N HCl and phosphate buffers pH 6.8 using dissolution apparatus II. The dissolution from liquid SMEDDS and solid SMEDDS was significantly high (P<0.0001) compared to drug...
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