Posted by admin on Aug 31, 2018 in |
Objective: To know the occurrence, onset and severity of infusion reactions associated with anticancer drug in an oncology hospital. Methods: For the patients who developed infusion reactions, causative drug, cycle of therapy, onset and duration of reaction, associated symptoms were recorded. The adverse drug reaction reporting form (yellow form) was used to report the infusion reaction. On the basis of reported and notified reaction, the severity of reactions was determined in accordance with NCI toxicity criteria, further assessed and evaluated for its causality and severity by using Naranjo’s causality assessment scale, Hartwig’s severity assessment scale. Results: During the study period 24 (0.18%) patients developed an infusion reaction to the anticancer therapeutic agents. Of these reactions, 33.32 % occurred during infusion of taxanes and monoclonal antibodies (MABs), 24.99% occurred during the use of platinum agents. In 54% patients, the infusion reactions occurred within the first hr of the infusion, 14 patients (58.33 %) developed a reaction in the first cycle of treatment. 79.16% ADRs were found to be possible, 12.5%...
Read More
Posted by admin on Aug 31, 2018 in |
WHO’s global health expenditure data base explores internationally comparable data on health spending in all WHO Member States. The report incorporates data analytics for various diseases, health expenditure and death toll etc., globally. Viral diseases have always been a burning issue for morbidity and mortality, worldwide. Viral diseases such as Chickenpox, Malaria, Cholera, Bronchitis, Tuberculosis, Meningitis, HIV, Dengue, and Chikungunya etc. have been challenging the medical practitioners, pharmacists, researchers and consumers since decades. Major out of pocket expenditure goes towards the medication of these diseases. For the medication of viral diseases, numbers of pharmaceutical companies are working in the segment of prescription drugs with focusing on different chemical moieties having antiviral activity. The rising expenditures for the prescription of these drugs are a major problem for public and private payers in many countries. In preview of this fact, an investigation is carried out for prescription drugs on the available parameters of price, chemical moieties and pharmaceutical companies in the domain of viral diseases- Chickenpox, Malaria, Bronchitis, and Tuberculosis diseases....
Read More
Posted by admin on Aug 31, 2018 in |
Purpose: Anacardium occidentale (Cashew) has been used by Folk medicines as a remedy for many diseases. In this study, we investigated the ameliorative activity of methanolic stem bark extract of Anacardium occidentale. Methods: Blood samples of the rats from each group were collected by tail bleeding for baseline biochemical test to know the state of the animals’ liver before the inducement of the injury. Thirty (30) Wistar rats were induced with CCl4 (1.5 ml/kg, b.wt, 20 % CCl4 / olive oil) for five days before treatment with the extract. After induction, elevated levels of the serum aminotransferases (ALT, AST), ALP and the decreased levels of ALB as compared to the enzyme markers levels before the induction of liver injury with CCl4 indicated hepatocellular injury. Results: Administration of the methanolic extract of Anacardium occidentale of different concentration (250, 500 and 1000 mg/kg b.wt oral) for five days reversed the impact of CCl4 toxicity significantly (P<0.05) on the serum markers ALT, AST and ALP of the damaged liver as compared to...
Read More
Posted by admin on Aug 31, 2018 in |
The aim of this study was to investigate the antidiabetic and anti-inflammatory effects of probiotic Lactobacillus paracasei MCC3195 in high fructose fed type 2 diabetic rats. High fructose diet was used to induce type 2 diabetes in male albino wistar rats. L. paracasei MCC3195 was administered to rats at a single dose of 2×108 cfu/ml per rat for 8 week. The body weight, fasting blood glucose, oral glucose tolerance test, glycosylated hemoglobin, insulin, Liver glycogen level, lipid profile and oxidative stress parameters were analyzed. Interlukin-6 and Interlukin-10 were also estimated in serum. Histopathology analysis of pancreas and liver injury were done. At 8 week body weight, FBG, glucose tolerance, HbA1c, insulin, liver glycogen level, total cholesterol, triacylglycerol, LDL-C, VLDL-C, lipid peroxidation and IL-6 were significantly increased in diabetic rats, while administration of L. paracasei MCC3195 significantly decreased these factors. The level of HDL-C, reduced glutathione, superoxide dismutase, catalase and IL-10 were significantly decreased in diabetic rats, whereas administration of L. paracasei MCC3195 significantly increased these factors. Administration of L....
Read More
Posted by admin on Aug 31, 2018 in |
Objective: Simple, rapid, sensitive, precise and reproducible specific UV spectrophotometric method for the determination of Aceclofenac (ACE) and Tramadol (TRM) in bulk drug and pharmaceutical dosage form were developed and validated. Methods: A simple double beam UV spectrophotometric method has been developed and validated with different parameters such as linearity, precision, repeatability, limit of detection (LOD), Limit of Quantification (LOQ), accuracy as per ICH guidelines. Results: UV-visible spectrophotometric method, measurement of absorption at maximum wavelength in 10 ml methanol and volume make with water solvent system as reference ACE and TRM were found to be at 203 nm and 241 nm respectively. The drug obeyed the Beer’s law and showed good correlation. Beer’s law was obeyed in concentration range 5 – 25 µg/ml for ACE and 2 – 10 µg/ml for TRM respectively with correlation coefficient was 0.999. The LOD and LOQ of ACE were found to be 4.7862 μg/ml and 14.50 μg/ml, TRM were found to be 2.0518 μg/ml and 6.2176 μg/ml, respectively. Percentage assay of ACE and...
Read More
