Posted by admin on Jul 31, 2018 in |
A sensitive, simple, accurate and fast method for vitamin C and E determination in pure and drug formulations using spectrophotometric was developed. The developed method is based on the formation of the charge transfer complex via the reaction between vitamins and Fe+3 [FeNH4(SO4)2.12H2O] in the presence of K3Fe(CN)6 which lead the formation of a blue-greenish colored product that has a maximum absorption at λmax=743 nm. The optimum reaction conditions such as temperature, volume, reaction time and pH were studied. The linear dynamic range for the intensity versus vitamins concentrations are 0.05-28 and 0.5-28 μg/mL for vitamin C and E respectively, with LOD values of 0.01 and 0.09 μg/mL and LOQ values of 0.033 and 0.297 μg/mL. The correlation coefficient (R2) is 0.9993, while the percentage linearity (%R2) was 99.93%. %R.S.D for the repeatability (n=3) is < 0.3%. The method was applied successfully for the determination of vitamin C and E in pharmaceutical preparation. The new method can be accepted as an alternative analytical method for the determination of the...
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Posted by admin on Jul 31, 2018 in |
: In traditional Ayurved, numbers of medicated ghee formulations are prescribed to regulate person’s cognitive functions. Vachadi ghrita [VG], a medicated ghee formulation is prescribed to maintain healthy process of intellect and memory. In recent experimental studies, positive action of VG on animal’s memory was proved. Thus to generate clinical evidence, the study was attempted to evaluate the therapeutic potential of VG on healthy individual’s memory using PGI memory scale test. Methods: Non randomized positive controlled clinical trial was carried out in ninety healthy individuals. Thirty participants from two groups received VG and Cow ghee respectively. Plain control group participants did not receive any drug. Drugs were administered orally in 10 g dose twice a day for continuous 30 days. PGI memory scale was used to analyze before and after treatment effects of drugs on learning and memory ability in healthy individuals. Results: The participants of Vachadi ghrita showed significant change in scores of PGI scale as compared to the participants of plain (p<0.01) and cow ghee groups (p<0.05)....
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Posted by admin on Jul 31, 2018 in |
Aim and Objective: Drug utilization research help in identification of the clinical use of drugs in population and its impact on health care system and to evaluate the rational drug usage. To study prescription pattern, to evaluate the adherence to treatment guidelines in diabetic patients attending the medical outpatient department in a tertiary care teaching hospital. Drug utilization research help in identification of the clinical use of drugs in population and its impact on health care system. To select the rational use of drugs as a predominant technique for the utilization of selective drugs in diabetes mellitus patients. Methodology: A cross-sectional retrospective study was carried out for 6 months in diabetic patients in the General Medicine Department. Data of 280 patients were collected and evaluated. Results: Total 280 diabetes mellitus patients were admitted. In this study, almost all prescriptions were with polypharmacy. The pattern of drug prescription in diabetes mellitus shows that insulin (22.14%) was most frequently prescribed followed by glimepiride (16.78%) and metformin (8.21%). In sulfonylureas monotherapy are...
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Posted by admin on Jul 31, 2018 in |
Objective: To assess the drug utilization evaluation of antihypertensive agents in diabetic and non-diabetic patients with chronic kidney disease. Method: Retrospective observational study was conducted in inpatient Nephrology department of B.B.R. Hospital from Sep 2016 to Feb 2017 and 155 case records of patients diagnosed with CKD and HTN, above 18 yrs of age, belonging to both genders were collected. Required Information from the patient’s case sheets was collected using a well designed data collection form. Results: The prevalence of CKD is more in male than in female and most commonly age group of > 60 yr was affected with CKD. Our study showed that majority of patients needed multiple drug therapy to control hypertension. Diuretics were most commonly prescribed drugs. The preferable drugs given among anti-hypertensive were diuretics, calcium channel blockers, beta blockers, alpha blockers, ARB’S. Conclusion: Most of the CKD patients were Male (63.87%) in distribution. Of the 155 cases, 69.03% of patients were also suffering from diabetic. Majority of patients (both diabetic and non-diabetic hypertensive patients...
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Posted by admin on Jul 31, 2018 in |
Depression is a chronic, recurring, and potentially life-threatening illness. The present work is to formulate floating tablets of Venlafaxine hydrochloride as this drug is used to treat depression. GIT absorption of Venlafaxine hydrochloride is poor due to low aqueous solubility. Thus, an attempt was made to enhance it gastric residence time that will improve its dissolution profile. The floating tablets were prepared by direct compression method. The Fourier Transform Infrared Spectroscopy revealed absence of any drug – polymer interactions. The floating tablets were evaluated for hardness, thickness, friability and drug content. The drug content of tablets was in range of 97.43 ± 1.56 to 98.71 ± 2.87%. The floating lag times of tablets for all batches were found in the range of 36.0 ± 1.1 to 68.0 ± 2.9 sec. The radiographic study of tablets containing barium meal showed that floating tablets remained buoyant for more than 12 h. The drug release from floating tablets followed Korysmer Pappas model. The results suggested that prepared floating tablets containing Venlafaxine hydrochloride...
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