Posted by admin on Sep 30, 2018 in |
Extrapyramidal symptoms (EPS) are the most common adverse effect of antipsychotic drugs. Haloperidol is atypical antipsychotic agents which has high potency, effectively used against delusion, hallucinations and have increased propensity to cause drug induced EPS. The adverse effects of haloperidol include muscle stiffness, parkinsonism, uncontrolled or slowed movements of any part of the body. Here we report a case of 33 years old male patient developed EPS after intramuscular administration of haloperidol for delusion disorder. After 3 weeks patient developed muscle stiffness and reduced movements. The patient was treated with Inj. promethazine (phenergan) 25 mg which showed gradual improvement in clinical condition after a week. Hence, physicians should evaluate the patient condition regularly to prevent the progression of adverse events, which improves the patient condition physically and economically. Primary management includes proper diagnosis, discontinuation of offending drugs, reduction of risk factors and supportive medical management. Second generation antipsychotics have the lowest propensity to cause extrapyramidal symptoms can be used based on the patient...
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Posted by admin on Sep 30, 2018 in |
Introduction and Aims: Combination antiretroviral therapy (cART) has improved morbidity and mortality in patients with HIV across countries including countries in sub-Sahara Africa. However, cART is associated with renal impairment. The lack of pre-cART data in a recently published study limited the discussion on renal-based treatment outcomes with cART, which could have important clinical implications. Consequently, the aim of this paper is to correct this. Methods: Longitudinal retrospective study, with renal function assessed pre-cART and at various time points on cART using the Cockcroft-Gault method. The data source was the patients’ care booklets. Results: 71 patients were included. The majority were adults and female. Before cART initiation, 70.4% and 29.6% had abnormal and normal CrCl, respectively. CrCl was normalised in 24% of patients, while abnormal in the remainder. The mean (median) time to normalisation was 47.4 (33.7) months, observed more in paediatric than adult patients (p = 0.014). However, in paediatric patients, normalisation took longer than in adult patients. The reduction in CrCl, was observed at variable time points....
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Posted by admin on Sep 30, 2018 in |
The objective of this study is to develop extended release matrix tablet of antihypertensive drug benidipine hydrochloride (BH) and to study its drug release pattern. BH has mean elimination half-life is ~3 h and requires dosing every 4 – 5 h in order to maintain optimal relief and is used orally in the management of hypertension and angina pectoris, but this frequent administration produces side effects like dizziness, headache. So in this study we have achieved to release drug for extended period of time up to more than 18 h for treatment of hypertension, for continuous 24 h control of blood pressure (BP), by taking polymers hydrophilic polymers, hypromellose (hydroxyl propyl methyl cellulose [HPMC] K100M), and polyacrylate polymers, eudragit RL100 and eudragit RS100 and also chitosan (CS) in order to find the suitable formulation. The tablets were prepared by direct compression method and also agglomerative phase of comminution (APOC). In-vitro drug release was carried out under simulated gastric and intestinal condition to achieve drug release. Fourier transform infrared spectroscopy...
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Posted by admin on Sep 30, 2018 in |
The aspiration of the coeval cramming is connate with the entirety of second generation Super Porous Hydrogel Composites (SPHCs) with polyvinyl alcohol as a melded material. Conglomerates were unified by proving gas fanning approach. For coalescence, 50% Acrylamide solution (AM) and 50% Acrylic Acid solution (AA) were used as a monomer, 2.5% N, N’-methylene bisacrylamide (BIS) as a cross linker, 20% Ammonium Per Sulphate (APS) and 20% N, N, N’, N’- Tetramethylethylene Diamine (TEMED) as a polymerization assailant pair, 10% span 80 as a foam stabilizer were used. The gaffed super porous hydrogel’s were peg by inchoate enormity, computation of plausible density, porosity, bunion studies, void fraction, mechanical strength and surface morphology muse. In bifold distilled water, SPHCs trot out appalling accretion in their stasis bunion capacity. PVA revamp the bruise characteristics in twain the swelling media. SPHCs disport enriched mechanical clout as the concentration of polyvinyl alcohol is elevated. SEM images precisely marked the formation of interconnected pore, capillary channels, and the cross-linked polyvinyl alcohol molecules were espied...
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Posted by admin on Sep 30, 2018 in |
The present study assayed the antifungal, larvicidal and antioxidant properties of the aqueous and acetone extracts of root and shoot of Biophytum sensitivum (Linn.) DC. The aqueous extracts of both root and shoot had little activity against the three test fungi such as A. niger, A. flavus and Penicillium. The acetone shoot extract was also ineffective against these fungi. However, the acetone root extract exhibited magnificent antifungal activity against A. flavus (zone of growth inhibition of 33.5 mm); but moderately affected the growth of Penicillium (9.5 mm), in the disc diffusion assay. The acetone root extract had no activity on A. flavus. The aqueous extracts of root and shoot of B. sensitivum were also assayed for larvicidal activity on the the 3rd and 4th instar mosquito larval stages. The shoot extract exhibited potent larvicidal activity, with 100% mortality induced in the larvae, within 48 h of exposure with the extract. The root extract on the contrary, had negligible activity against the mosquito larvae, exhibiting only 30% larvicidal activity, even...
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