Posted by admin on Aug 31, 2018 in |
Plants have been used in traditional medicine for several thousand years since which may have been described to have curative value. Terminalia chebula (TC), Terminalia arjuna (TA) and Holarrhena antidysenterica (HA) are very important medicinal plants in the traditional Indian systems of Ayurveda and Siddha. In this work, fruit of Terminalia chebula, bark of Terminalia arjuna and Holarrhena antidysenterica were selected for experiments. 80% methanolic crude extracts of these plants were fractionated by diethyl ether and ethyl acetate. Diethyl ether fraction of 80% methanolic extract (DM) and ethyl acetate fraction of 80% methanolic extract (EM) of all the three plants were compared for their phyto-chemical, antioxidant and cytotoxicity to find out their therapeutic potential. The phenolic content was determined by Folin-Ciocalteu method and was found to be higher in Terminalia chebula extracts (>36 mg GAE/g)). The antioxidant activity was assayed through some in-vitro methods such as DPPH radical scavenging assay, phosphomolybdenum method and reducing power assay. Antioxidant activity was also found to be highest in Terminalia chebula extracts. Cytotoxicity...
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Posted by admin on Aug 31, 2018 in |
The present study is designed to evaluate the in vitro antioxidant and in-vivo anti-inflammatory activities of Polyalthia longifolia (Sonn.) Thwaite seeds. Initially, the extracts (Nonpolar to polar) were screened for in-vitro antioxidant activity by DPPH, nitric oxide radical, hydroxyl radical, and superoxide radical considering ascorbic acid as standard. Among the extracts the ethyl acetate and methanolic extracts showed greater antioxidant activity further, the antioxidant activity of the extracts is supported by evaluating the total phenol content (114±1.7, 146.5±2.4 mg/g gallic acid equivalents respectively) and flavonoid content (2.86±0.10, 6.2±0.12 mg/g rutin equivalents respectively). Based on the initial study, the ethyl acetate and methanol extracts were evaluated for acute anti-inflammatory activity against the egg albumin (1%) induced inflammation. The selected extracts (200, 400 mg/kg) were administered 1 hour prior to the induction of inflammation. The anti-inflammatory activity is measured as a decrease in paw edema, measured at regular intervals (0.5, 1, 2, 3, 4, 5 h) of time, taking diclofenac (5 mg/kg) as a standard drug. Both the extracts showed significant...
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Posted by admin on Aug 31, 2018 in |
Internationally there has been research on large scale for determination of efficiency of cigarette filters but in India it still remains a topic of discussion. Being the second largest consumers of tobacco and tobacco products and one of the largest and fastest growing consumers of cigarettes, such studies need to be undertaken at a greater level to assess the risk and hazards of cigarette smoking. The government of India seems to focus more on the taxation policy on tobacco products with a view that increased taxes on tobacco products will make it difficult for common masses to consume them. However, the Global Adult Survey conducted by the Government of India, Ministry of Health and Family Welfare clearly indicates that despite of increased taxes on tobacco and tobacco products, the number of consumers have grown many folds in last one decade. Most of the researches have used smoking machine regime for determination of human smoke yields from spent filter, however as per the WHO, no smoking machine can actually mimic...
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Posted by admin on Aug 31, 2018 in |
Buccal tablets are prepared by direct compression method using different polymers like carbopol, hydroxypropyl methylcellulose and sodium alginate. Nine formulations were prepared while (F1) to (F3) were prepared by taking individual concentrations whereas all the remaining formulations were prepared by taking combinations of polymers. Aim of study is to develop and optimize mucoadhesive buccal tablets of candesartan by direct compression method. All the batches were evaluated for thickness, weight variation, hardness and content uniformity. In-vitro release study is carried and release mechanisms were explored. Individual carbopol concentration (F1) has high swelling index with low water absorption ratio. Individual concentration of sodium alginate (F3) obtained high drug release, while low concentration of carbopol and high concentration of hydroxypropyl methylcellulose in combinations (F4) gave 86% drug release and with equal ratios of carbopol and hydroxypropyl methylcellulose (F7) gave 88% drug release. But low concentration of hydroxypropyl methylcellulose and high concentration of sodium alginate (F5) in combination form gave 95% drug release. While equal ratios of both hydroxypropyl methylcellulose and sodium alginate...
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Posted by admin on Aug 31, 2018 in |
Background: Metabolic syndrome has a significant impact on the severity and prognosis of various risk factors that may contribute to cardiovascular events. We examined the clinical profile and prevalence of MetS among MI patients along with the estimation of associated risk factors and determined the components of the MetS which conferred the paramount cardiovascular risk. Methods: A prospective observational study was conducted for duration of 10 months on a total of 117 MI patients who were further categorized based on IDF criteria for MetS at a tertiary care hospital in India. Statistical analysis of collected data was done using SPSS 22 for windows version. Results: Among all the parameters used for defining MetS, positive predictive value was highest for fasting blood sugar (p=0.001) followed by high blood pressure (p=0.005) and elevated triglycerides (p=0.850). MetS was significantly more prevalent in MI patients with a prevalence of 51.28% (p<0.001). Conclusion: The study depicted high prevalence of MetS among MI patients which implies greater risk of developing cardiovascular diseases. A systematic approach...
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