Posted by admin on Sep 30, 2018 in |
Polymorphonuclear leukocytes or neutrophils are important components of host defense machinery. They are the first line of defense against invading microorganisms. In the present research work, ability of human neutrophils to phagocytose was studied in-vitro by exposing the polymorphonuclear leukocytes to Candida albicans and the phagocytic capacity was evaluated using aqueous extract of leaves powder of Putranjiva roxburghii Wall. The chemotactic activity that is the movement of polymorphonuclear leukocytes towards a chemical stimulant was studied in-vitro by placing polymorphonuclear leukocytes in presence of a chemotactic agent Zymosan using aqueous extract of leaves powder of Putranjiva roxburghii...
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Posted by admin on Sep 30, 2018 in |
Background: Raktachandan / Pterocarpus santalinus is mentioned to have edema reducing property in Ayurvedic literature. Studies have been performed using its methanolic extract for anti-inflammatory, analgesic and antioxidant activities. Since, Ayurveda advises to use it as a decoction, we planned to study the acute anti-inflammatory activity of decoction prepared from Pterocarpus santalinus bark-wood powder. Methodology: Albino rats of either sex were divided into 4 groups of 6 rats each (Group I – Control (CMC-vehicle), Group II – Ibuprofen suspension, Group III – P. santalinus suspension 3.5 mg/kg, Group IV – P. santalinus suspension 7 mg/kg. All the experimental animals were given standard and test drugs orally, 45 min before inducing inflammation. Acute inflammation was induced by injecting 0.1ml of 1% carrageenan solution in sub-plantar tissue of left hind paw of the rats. Paw volume (Plethysmometer) and pain assessment (Randall and Selitto paw withdrawal method) were done at 0 h (before medication), then at 1 h, 2 h, 3 h and 4 h after induction of inflammation. Data was analysed...
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Posted by admin on Sep 30, 2018 in |
Felodipine is a poorly water soluble drug having 15% oral bioavailability. In the present study Self micro emulsifying drug delivery system of felodipine was developed to improve its solubility and bioavailability. SMEDDS were prepared by phase titration method and ternary phase diagram was constructed using Chemix software. Based on solubility of drug in the excipients, capmul MCM, oleic acid, Tween 80 and PEG 400 were selected as oil, surfactant and co-surfactant respectively. Liquid SMEDDS were characterized for self-micro emulsification time, droplet size, poly dispersity index, zeta potential, drug release, ex-vivo permeation. The optimized liquid SMEDDS formulation F16 contained capmul MCM (35%), tween 80 (55%), PEG 400 (10%). Formulation F16 has size of 13.66 nm, zeta potential-25.7 mV, drug release 78% in 8 h. The optimized liquid SMEDDS were converted into solid SMEDDS by adsorbing on to neusilin. The drug release was studied in 0.1N HCl and phosphate buffers pH 6.8 using dissolution apparatus II. The dissolution from liquid SMEDDS and solid SMEDDS was significantly high (P<0.0001) compared to drug...
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Posted by admin on Sep 30, 2018 in |
Objective: Guggulu is one of the important dravya (drug) used in Ayurvedic formulations since ancient time which means “Protection against diseases”. Ashuddha guggulu has physical and chemical impurities which need to be eliminated before using in formulation by shodhana. The present study was conducted to evaluate and compare the effect of different shodhana processes i.e. Samanya shodhana and Vishesh shodhana on properties of guggul by employing various physicochemical and chromatographic methods. Method: Physicochemical screening was done by evaluating ash, Acid Insoluble Ash (AIA), Loss on Drying (LOD), Water Soluble Extractive (WSE), Alcohol Soluble Extractive (ASE) and Ethyl acetate Soluble Extractive (EASE). Chromatographic analysis was performed to estimate guggulsterone (E and Z) content and to confirm the presence of ellagic acid and gallic acid, tinosporaside and diosgenin after shodhana with Triphala kwath, Gulvel kwath and Dashmool kwath respectively, using High Performance Thin Layer Chromatography (HPTLC). Result: The Physico-chemical studies showed decrease in LOD, Ash and AIA content and increase in extractive values such as ASE and EASE of guggul after...
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Posted by admin on Sep 30, 2018 in |
In the present study a series of novel 2-aryl substituted benzothiazoles were synthesized. The synthesized benzothiazole (BTA) derivatives were characterized physicochemically, by elemental analysis and spectral (IR and 1H-NMR) analysis. The synthesized compounds were screened for their in-vitro antifungal activity against Candida albicans, Aspergillus niger and Cryptococcus neoformans by cup plate method. The results revealed that three compounds namely BTA-3, BTA-9 and BTA-10 have better or equal antifungal activity compared to the standard fluconazole. Further research on benzothiazoles can warrant more consideration on benzothiazoles as prospective antifungal...
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